A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
Gosse Jan Adema,Franca C. Hartgers,R.G.G. Verstraten,E. de Vries,G. Marland,S. Menon,Jessica Foster,Y.Q. Xu,P. Nooyen,Terrill K. McClanahan,Kevin B. Bacon,Carl G. Figdor +11 more
TL;DR: The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC- cK1 has an important rule in the induction of immune responses.
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Abstract: Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T cells1,2. Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a central role in the initiation of immune responses and allows them to be used in therapeutic strategies against cancer, viral infection and other diseases. How they interact preferentially with naive rather than activated T lymphocytes is still poorly understood. Chemokines direct the transport of white blood cells in immune surveillance3,4. Here we report the identification and characterization of a C-C chemokine (DC-CK1) that is specifically expressed by human dendritic cells at high levels. Tissue distribution analysis demonstrates that dendritic cells present in germinal centres and T-cell areas of secondary lymphoid organs express this chemokine. We show that DC-CK1, in contrast to RANTES, MIP-1α and interleukin-8, preferentially attracts naive T cells (CD45RA+). The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC-CK1 has an important rule in the induction of immune responses.
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Citations
C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential
David P. Andrew,Nancy Ruffing,Chang H. Kim,Wenyan Miao,Heidi Heath,You Li,Kristine E. Murphy,James Campbell,Eugene C. Butcher,Lijun Wu +9 more
TL;DR: It is shown that CCR4 is a major receptor for MDC and TARC on T lymphocytes, as anti-CCR4 mAbs significantly inhibit the migration of these cells to MDC, consistent with a role for C CR4 as a major trafficking receptor for systemic memory T cells.
218
Chemokines: understanding their role in T-lymphocyte biology
Stephen G. Ward,John Westwick +1 more
TL;DR: The present review describes the current understanding of the structure and expression of chemokines and their receptors, the effects of Chemokines on T-cell function(s), the intracellular signalling pathways activated by chemokites and the role of certain chemokine receptors in determining sensitivity to HIV-1 infection.
211
Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation.
TL;DR: The available data suggest that IFN-α/β serves as a link between the innate response to infection and the adaptive immune response, and evidence indicating thatIFN-β can enhance and modulate immune responses in vivo is discussed.
209
A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.
Mitsuharu Ohno,Tomohisa Hirata,Makoto Enomoto,Takeyoshi Araki,Hiroshi Ishimaru,Tsuneo A. Takahashi +5 more
TL;DR: The cloning of a novel human gene encoding the putative orphan receptor, C5L2, belonging to a subfamily of C3a, C 5a and formyl Met-Leu-Ph receptors that are related to the chemokine receptor family is reported.
208
Chemokines and dendritic cell traffic.
TL;DR: The interaction of DC with chemokines is essential to the function of these cells in normal and pathological conditions and may provide tools for novel therapeutic strategies.
198
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