Journal Article10.1126/SCIENCE.1103717
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
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Abstract: Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region motif is implicated in this process.
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The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum
TL;DR: Analysis of the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P. falciparum demonstrates that this parasite has evolved an extremely specialized mode of transcriptional regulation that produces a continuous cascade of gene expression, beginning with genes corresponding to general cellular processes, such as protein synthesis, and ending with Plasmodium-specific functionalities.
PlasmoDB: a functional genomic database for malaria parasites
Cristina Aurrecoechea,John Brestelli,Brian P. Brunk,Jennifer Dommer,Steve Fischer,Bindu Gajria,Xin Gao,Alan R. Gingle,Gregory R. Grant,Omar S. Harb,Mark Heiges,Frank Innamorato,John Iodice,Jessica C. Kissinger,Eileen Kraemer,Wei Li,John A. Miller,Vishal Nayak,Cary Pennington,Deborah F. Pinney,David S. Roos,Chris Ross,Christian J. Stoeckert,Charles Treatman,Haiming Wang +24 more
TL;DR: PlasmoDB as mentioned in this paper is a functional genomic database for Plasmodium spp. that provides a resource for data analysis and visualization in a gene-by-gene or genome-wide scale.
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Wang H: PlasmoDB: a functional genomic database for malaria parasites
Cristina Aurrecoechea,John Brestelli,Brian P. Brunk,Jennifer Dommer,Steve Fischer,Bindu Gajria,Xin Gao,Alan R. Gingle,Greg Grant,Omar S. Harb,Mark Heiges,Frank Innamorato,John Iodice,Jessica C. Kissinger,Eileen Kraemer,Wei Li,John A. Miller,Vishal Nayak,Cary Pennington,Deborah F. Pinney,David S. Roos,Chris Ross,Christian J. Stoeckert,Charles Treatman,Haiming Wang +24 more
- 01 Jan 2008
TL;DR: The latest release, PlasmoDB 5.5, contains numerous new data types from several broad categories—annotated genomes, evidence of transcription, proteomics evidence, protein function evidence, population biology and evolution.
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Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M. Carlton,Jane M. Carlton,John H. Adams,Joana C. Silva,Shelby L. Bidwell,Hernan Lorenzi,Elisabet Caler,Jonathan Crabtree,Jonathan Crabtree,Samuel V. Angiuoli,Emilio F. Merino,Paolo Amedeo,Qin Cheng,Richard M.R. Coulson,Brendan S. Crabb,Hernando A. del Portillo,Kobby Essien,T. Feldblyum,Carmen Fernandez-Becerra,Paul R. Gilson,Amy H. Gueye,Xiang Guo,Simon Kang’a,Taco W. A. Kooij,Michael Korsinczky,Michael Korsinczky,Esmeralda V. S. Meyer,Vish Nene,Ian T. Paulsen,Owen White,Stuart A. Ralph,Qinghu Ren,Tobias Sargeant,Steven L. Salzberg,Christian J. Stoeckert,Steven A. Sullivan,Marcio Massao Yamamoto,Stephen L. Hoffman,Jennifer R. Wortman,Malcolm J. Gardner,Mary R. Galinski,John W. Barnwell,Claire M. Fraser-Liggett +42 more
TL;DR: The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.
Comparative genomics of trypanosomatid parasitic protozoa.
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Gaëlle Blandin,Matthew Berriman,Jonathan Crabtree,Gautam Aggarwal,Elisabet Caler,Hubert Renauld,Elizabeth A. Worthey,Christiane Hertz-Fowler,Elodie Ghedin,Christopher S. Peacock,Daniella Castanheira Bartholomeu,Brian J. Haas,Anh Nhi Tran,Jennifer R. Wortman,U. Cecilia M. Alsmark,Samuel V. Angiuoli,Atashi Anupama,Jonathan H. Badger,Frédéric Bringaud,Eithon Cadag,Jane M. Carlton,Gustavo C. Cerqueira,Todd Creasy,Arthur L. Delcher,Appolinaire Djikeng,T. Martin Embley,Christopher R. Hauser,Alasdair Ivens,Sarah K. Kummerfeld,José B. Pereira-Leal,Daniel Nilsson,Jeremy Peterson,Steven L. Salzberg,Joshua Shallom,Joana C. Silva,Jaideep P. Sundaram,Scott J. Westenberger,Owen White,Sara E. Melville,John E. Donelson,Björn Andersson,Kenneth Stuart,Kenneth Stuart,Neil Hall +46 more
TL;DR: No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed.
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TL;DR: The results of an international collaboration to produce a high-quality draft sequence of the mouse genome are reported and an initial comparative analysis of the Mouse and human genomes is presented, describing some of the insights that can be gleaned from the two sequences.
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TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
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