A comprehensive overview of radioguided surgery using gamma detection probe technology
Stephen P. Povoski,Ryan L. Neff,Cathy Mojzisik,David M. O'Malley,George H. Hinkle,Nathan Hall,Douglas A Murrey,Michael V. Knopp,Edward W. Martin +8 more
TL;DR: In the current review, this work has attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.
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Abstract: The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.
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References
•Journal Article
Cytoreductive surgery in patients with advanced-stage carcinoid tumors.
Seza A. Gulec,Mountcastle Ts,D. J. Frey,Cundiff Jd,Mathews E,Lowell Anthony,O'Leary Jp,J. P. Boudreaux +7 more
TL;DR: Thirty patients who were previously diagnosed to have "unresectable carcinoid disease" were treated using a multimodality approach over a period of 2 years, finding Aggressive surgical exploration and tumor debulking could be performed with significantly improved symptomatic outcome and relatively minor complications.
57
Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer.
Franca Melfi,Antonio Chella,G Franco Menconi,Francesco Givigliano,Giuseppe Boni,Giuliano Mariani,Paola Sbragia,Carlo Alberto Angeletti +7 more
TL;DR: Preliminary results demonstrate the feasibility of this procedure in identifying the first site of potential nodal metastases of NSCLC and the actual clinical impact of this technique remains to be elucidated by further investigation in larger groups of patients.
57
Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small-cell lung cancer.
Didier Lardinois,Thomas Brack,Ariana Gaspert,T. Spahr,Didier Schneiter,Hans C. Steinert,Walter Weder +6 more
TL;DR: Preliminary results suggest that preoperative bronchoscopic radioisotope injection for SLN identification is a safe and simple method, improving accuracy of SLN detection in comparison to intraoperative technique.
57
Outcomes for patients with T1 squamous cell cancer of the vulva undergoing sentinel node biopsy
Keith Terada,David Shimizu,David Shimizu,Caroline S. Jiang,Caroline S. Jiang,Jan H. Wong,Jan H. Wong +6 more
TL;DR: The survival for patients with early vulvar cancer treated with sentinel node dissection and radical local excision appears excellent, and none of the patients with negative sentinel nodes has died of cancer.
56
Osteoid osteoma of the spine: a novel technique using combined computer-assisted and gamma probe-guided high-speed intralesional drill excision.
Barend J. van Royen,Johannes C Baayen,Rik Pijpers,David P Noske,Ditmar Schakenraad,Paul I. J. M. Wuisman +5 more
TL;DR: The combination of both computer-assisted surgery and &ggr; probe-guided high-speed drill excision for osteoids osteoma of the spine helps to localize and excise the nidus of the osteoid osteoma with minimal bone resection of the posterior spinal structures.
56