A comprehensive overview of radioguided surgery using gamma detection probe technology
Stephen P. Povoski,Ryan L. Neff,Cathy Mojzisik,David M. O'Malley,George H. Hinkle,Nathan Hall,Douglas A Murrey,Michael V. Knopp,Edward W. Martin +8 more
TL;DR: In the current review, this work has attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.
read more
Abstract: The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Photoacoustic clinical imaging
Idan Steinberg,David M. Huland,Ophir Vermesh,Hadas Frostig,Willemieke S. Tummers,Sanjiv S. Gambhir +5 more
TL;DR: The various clinical and pre-clinical literature is surveyed and the potential applications and hurdles that still need to be overcome are discussed.
482
Multiplexed imaging for diagnosis and therapy
TL;DR: Criteria for conducting multiplexed imaging is evaluated, and its opportunities for improving patient diagnosis and the monitoring of therapy are discussed, and targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment.
150
A Pilot Study Utilizing Intraoperative Lymphoscintigraphy for Identification of the Sentinel Lymph Nodes in Vulvar Cancer
Steven L. DeCesare,James V. Fiorica,W S Robert,Douglas S. Reintgen,Hector Arango,Mitchel S. Hoffman,Chris Puleo,Denis Cavanagh +7 more
TL;DR: Since sentinel lymph nodes can be localized transcutaneously, this technique may be useful for selective lymphadenectomy and larger patient accrual is necessary to verify this technique.
149
Nuclear probes and intraoperative gamma cameras.
Sherman Heller,Pat Zanzonico +1 more
TL;DR: Intraoperative sentinel lymph node as well as tumor detection may be improved under some circumstances by the use of beta (negatron or positron), rather than gamma detection, because the very short range of such particulate radiations eliminates the contribution of confounding counts from activity other than in the immediate vicinity of the detector.
115
Intraoperative gamma cameras for radioguided surgery: technical characteristics, performance parameters, and clinical applications.
TL;DR: The characteristics, performance, and clinical use of SGCs, which are hand-held and small enough to be easily managed by surgeons during their procedures, are discussed.
114
References
Intraoperative methods to stage and localize pancreatic and duodenal tumors
TL;DR: The authors performed laparoscopy with ultrasound on 50 consecutive patients with adenocarcinoma of the pancreas or liver who appeared to have resectable tumors based on preoperative computed tomography and found that laparoscopic ultrasound was the best method to select patients for curative surgery.
73
Use of the sentinel node procedure to stage endometrial cancer.
TL;DR: The sentinel lymph node (SN) procedure can reliably determine lymph node status in women with endometrial cancer, including those with presumed early-stage disease and/or well-differentiated tumours.
73
Application of an [18F]Fluorodeoxyglucose-Sensitive Probe for the Intraoperative Detection of Malignancy
TL;DR: The use of a hand-held gamma-ray-sensitive probe to intraoperatively differentiate the radioactivity released from FDG from tumor-bearing and adjacent normal tissue may ultimately improve the ability to completely resect patients with metastatic disease.
73
Sentinel lymphonodectomy in nonmelanoma skin malignancies.
TL;DR: The value of sentinel lymphonodectomy in malignant melanoma is established, but experience with SLNE in nonmelanoma skin cancers is limited.
73
Sentinel lymph node biopsy for staging penile cancer
TL;DR: Data support the possibility that the sentinel lymph node is often the first site of regional lymphatic metastasis in penile cancer.
73