Journal Article10.1164/AJRCCM.159.1.9804134
A Community Study of Exhaled Nitric Oxide in Healthy Children
TL;DR: Age and immunological reactions to common allergens are associated with increased eNO in children and should be controlled for in studies of eNO.
read more
Abstract: Exhaled nitric oxide (eNO) is elevated in patients with inflammatory pulmonary diseases and it has attracted increasing interest as a simple, noninvasive marker of airway inflammation. Little is known, however, about factors that might affect eNO in healthy subjects. We measured eNO in 157 healthy 7- to 13-yr-old children (mean 9.7 yr, 77 girls), with no history of respiratory tract disease, using a recently validated, single-breath technique. Measurements of eNO were obtained at driving (mouth) pressures of 10, 15, and 20 cm H2O and 3 eNO plateaux were achieved for each child at each pressure. Exhaled NO decreased with increasing pressure (increasing expiratory flow) (p < 0.001) and increased with age (p < 0.001). Concentrations were greater in children with a positive skin prick test (p < 0.0001). Geometric mean eNO levels were 7.2 ppb in children with no positive skin prick tests (n = 116), 10.9 ppb in children with one positive reaction (n = 24), and 20.1 ppb in children with two or more skin reactions (n = 17). Age and immunological reactions to common allergens are associated with increased eNO in children and should be controlled for in studies of eNO. The mechanisms responsible for these associations require further study.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years
Frederik Buchvald,Eugenio Baraldi,Silvia Carraro,Benjamin Gaston,Johan C. de Jongste,Mariëlle W. Pijnenburg,Philip E. Silkoff,Hans Bisgaard +7 more
TL;DR: Fractional exhaled nitric oxide in healthy children is below 15 to 25 ppb depending on age and self-reported atopy, and higher FE NO was seen in children with self- reported rhinitis/conjunctivitis or hay fever.
370
Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children.
Robert C. Strunk,Stanley J. Szefler,Brenda R. Phillips,Robert S. Zeiger,Vernon M. Chinchilli,Gary L. Larsen,Kevin Hodgdon,Wayne J. Morgan,Christine A. Sorkness,Robert F. Lemanske +9 more
TL;DR: Findings suggest that eNO provides information about the asthmatic state consistent with information from other markers of inflammation and is a noninvasive technique that could be used in decisional management of children with asthma.
348
Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
T. J. Warke,P.S. Fitch,Vanessa Brown,R. Taylor,Jeremy Lyons,Madeleine Ennis,Michael D. Shields +6 more
TL;DR: Exhaled nitric oxide correlates closely with percentage eosinophils in BAL fluid in asthmatic children and is therefore likely to be a useful non-invasive marker of airway inflammation.
315
Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath
Carly Lane,Darryl A. Knight,S. Burgess,Peter Franklin,Friedrich Horak,J. Legg,Alexander Moeller,Stephen M. Stick +7 more
TL;DR: FeNO variability is largely determined by epithelial NOS2 expression with little contribution from other isoforms, suggesting that non-inducible NOS systems have important roles in determining airway reactivity, regulating inflammation, and might contribute significantly to NO measured in exhaled breath.
269
Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma
TL;DR: FENO is superior to baseline respiratory function and bronchodilator responsiveness in identifying preschool children with probable asthma, and the results emphasise the presence of airway inflammation in the early stages of asthma, even in young children.
232
References
Statistical methods for assessing agreement between two methods of clinical measurement.
TL;DR: An alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability.
47.6K
Statistical methods for assessing agreement between two methods of clinical measurement
TL;DR: In this article, an alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability, which is often used in clinical comparison of a new measurement technique with an established one.
34.6K
High nitric oxide production in human paranasal sinuses
Jon O. Lundberg,Tünde Farkas-Szallasi,Eddie Weitzberg,Johan Rinder,Jonas Lidholm,A. Änggåard,Tomas Hökfelt,Jan M. Lundberg,Kjell Alving +8 more
TL;DR: It is reported that NO in humans is produced by epithelial cells in the paranasal sinuses and is present in sinus air in very high concentrations, close to the highest permissible atmospheric pollution levels.
632
Single-breath nitric oxide measurements in asthmatic patients and smokers
TL;DR: The findings support a role for NO in the host defence response in asthma and suggest that NO measurements can discriminate between different types of lung disorders.
519
Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide.
Philip E. Silkoff,P. A. McClean,Arthur S. Slutsky,Henry Furlott,Eric Hoffstein,Suguru Wakita,Kenneth R. Chapman,John P. Szalai,Noe Zamel +8 more
TL;DR: There is a marked flow dependence of exhaled NO concentration and excretion, and exhaled pulmonary NO is best measured at very low flow rates to amplify the signal and must be related to the expiratory flow employed.
496
Related Papers (5)
[...]