A census of human RNA-binding proteins.
TL;DR: This work presents a census of 1,542 manually curated RBPs that are analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression, a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
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Abstract: Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation, transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins (RBPs) and ribonucleoproteins coordinate RNA processing and PTGR. The introduction of large-scale quantitative methods, such as next-generation sequencing and modern protein mass spectrometry, has renewed interest in the investigation of PTGR and the protein factors involved at a systems-biology level. Here, we present a census of 1,542 manually curated RBPs that we have analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression. Our analysis is a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
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Effects of RNA Binding Proteins on the Prognosis and Malignant Progression in Prostate Cancer.
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PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues
Marcin Sajek,Damian M. Janecki,Maciej J Smialek,Barbara Ginter-Matuszewska,Anna Spik,Sławomir Oczkowski,Erkut Ilaslan,Kamila Kusz-Zamelczyk,Maciej Kotecki,Maciej Kotecki,Jacek Blazewicz,Jacek Blazewicz,Jadwiga Jaruzelska +12 more
TL;DR: Mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1 are shown and the first report, to the best of the authors' knowledge, showing that an NANos protein directly binds RNA is reported, which highlights the mechanistic versatility of the PUM/NANOS machinery in mammalian posttranscriptional regulation.
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