Journal Article10.1016/0092-8674(92)90425-C
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter.
Yongjian Liu,D. Peter,Ali Roghani,Shimon Schuldiner,Gilbert G. Privé,David Eisenberg,Nicholas C. Brecha,Robert H. Edwards +7 more
TL;DR: Taking advantage of selection in MPP+, gene transfer followed by plasmid rescue is used to identify a cDNA clone that encodes a vesicular amine transporter that predicts a novel mammalian protein with 12 transmembrane domains and homology to a class of bacterial drug resistance transporters.
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About: This article is published in Cell. The article was published on 21 Aug 1992. The article focuses on the topics: Vesicular monoamine transporter 1 & Vesicular transport protein.
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Citations
Ligand Recognition by the Vesicular Monoamine Transporters
TL;DR: Although functional analysis indicates that each can recognize multiple monoamines as substrates, selective expression within dopamine, norepinephrine, and serotonin cell populations of the brain suggests that each probably transports a single substrate in vivo.
The Role of Glutathione in the Pathogenesis of Parkinson’s Disease
B. Drukarch,J. C. Stoof +1 more
- 01 Jan 1997
TL;DR: Idiopathic Parkinson’s disease is a progressive neurodegenerative disorder which manifests itself by bradykinesia in combination with rigidity, tremor and postural imbalance, and other neuronal systems, in particular noradrenergic neurons originating from the locus coeruleus, are affected by the disease process but to a substantially smaller extent.
Vacuolar H+-ATPase
Nathan Nelson
- 01 Jan 1996
TL;DR: This chapter provides an overview of some of the recent advancements in understanding the structure, function, molecular biology, biogenesis, and evolution of vacuolar-ATPases.
Distributional characteristics of vesicular monoamine transporter 2 in human embryonic brain and their correlation with Parkinson's disease
TL;DR: The weakened protective function of VMAT2 may be an important cause for the selective loss of dopaminergic neurons in SNC caused by PD.
Regulation der Aktivität der vesikulären Monoamintransporter VMAT1 und VMAT2 in neuroendokrinen Zellen und Neuronen
Markus Höltje
- 12 Sep 2000
TL;DR: In serotonin-depleted platelets from peripheral tryptophane-hydroxylase knockout mice no G-protein-dependent down-regulation of monoamine uptake was observed, and the vesicular transmitter content appears to be a likely factor of G- protein activation in platelets.
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