Journal Article10.1016/J.BIOS.2019.111397
A catalytic molecule machine-driven biosensing method for amplified electrochemical detection of exosomes.
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TL;DR: The proposed "principle-of-proof" biosensing method demonstrates a high specificity even in serum samples and suggests a potential use in clinic, which may provide sufficient information for disease diagnosis, especially early detection and prognosis monitoring of tumors.
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About: This article is published in Biosensors and Bioelectronics. The article was published on 15 Sep 2019.
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Citations
Aptamer-Based Detection of Circulating Targets for Precision Medicine.
Lingling Wu,Yidi Wang,Xing Xu,Yilong Liu,Bingqian Lin,Mingxia Zhang,Jialu Zhang,Shuang Wan,Chaoyong Yang,Chaoyong Yang,Weihong Tan,Weihong Tan,Weihong Tan +12 more
TL;DR: A broad overview of aptamer-based liquid biopsy techniques for precision medicine can be found in this article, where the authors present a summary of state-of-the-art strategies for multivalent aptamer assembly and aptamer interface modification.
419
Nanomaterials for Healthcare Biosensing Applications
Muqsit Pirzada,Zeynep Altintas +1 more
TL;DR: The latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.
Precise Capture and Direct Quantification of Tumor Exosomes via a Highly Efficient Dual-Aptamer Recognition-Assisted Ratiometric Immobilization-Free Electrochemical Strategy.
TL;DR: In this article, a dual-aptamer recognition system for precisely isolating and quantifying tumor exosomes from the complex biological environment based on hyperbranched DNA superstructure-facilitated signal amplification and ratiometric dual-signal strategies was presented.
190
A simple fluorescence aptasensor for gastric cancer exosome detection based on branched rolling circle amplification
Rongrong Huang,Lei He,Song Li,Hongna Liu,Lian Jin,Zhu Chen,Yongxiang Zhao,Zhiyang Li,Yan Deng,Nongyue He +9 more
TL;DR: A fluorescence assay for the determination of gastric cancer exosome determination based on branched rolling circle amplification (BRCA) and an aptamer to target specific exosomes with a high specificity and demonstrated that this aptamer-based biosensor may show potential for the early diagnosis of Gastric cancer.
142
Recent advances of aptasensors for exosomes detection
TL;DR: This review mainly summarizes the recent advances of single-stranded DNA (ssDNA) aptamer-based sensors for cancer and tumor-derived exosomes detection and introduces the exosomal proteins used as potential biomarkers of various cancers, and their specific ssDNA aptamers used in aptasensors.
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