A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
Daniel C. Leslie,Anna Waterhouse,Julia B Berthet,Julia B Berthet,Julia B Berthet,Thomas M. Valentin,Alexander Watters,Alexander Watters,Abhishek Jain,Philseok Kim,Benjamin Hatton,Benjamin Hatton,Benjamin Hatton,Arthur Nedder,Kathryn Donovan,Elana H. Super,Caitlin Howell,Caitlin Howell,Christopher P Johnson,Christopher P Johnson,Thy L. Vu,Thy L. Vu,Dana Bolgen,Sami A. Rifai,Anne Hansen,Michael Aizenberg,Michael Super,Michael Super,Michael Super,Joanna Aizenberg,Donald E. Ingber +30 more
TL;DR: A bioinspired, omniphobic coating is applied to tubing and catheters and it is shown that it completely repels blood and suppresses biofilm formation, which could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
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Abstract: Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
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Pathochemical Toxicity of Perfluorocarbon-5070, a Liquid Test Performance Fluid Previously Used in Dialyzer Manufacturing, Confirmed in Animal Experiment
Bernard Canaud,Pedro Aljama,Christian Tielemans,Vladimir Gasparovic,Alberto Gutierrez,Francesco Locatelli +5 more
TL;DR: It is concluded that liquid PF-5070 is a highly toxic compound when administered intravenously because of its emulsifying properties, and any liquid fluorocarbon compounds in medical devices with blood contact and particularly in the dialyzer manufacturing should be considered with caution.