Journal Article10.1007/S00259-006-0289-X
99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits
Seigo Ishino,Yuji Kuge,Yuji Kuge,Nozomi Takai,Nagara Tamaki,H. William Strauss,Francis G. Blankenberg,Masashi Shiomi,Hideo Saji +8 more
37
TL;DR: The present study in WHHLMI rabbits showed higher 99mTc-annexin A5 accumulation in grade IV atheroma than in other more stable lesions, which may be useful in identifying athersoma that is at higher risk for rupture and possibly in assessing the response to anti-atherosclerosis therapy.
read more
Abstract: Purpose
Apoptosis is commonly observed in advanced atherosclerotic lesions. 99mTc-annexin A5 (99mTc-annexin V) has been proposed as a potential tracer for imaging apoptosis in atherosclerotic plaques. Accordingly, we determined the usefulness of 99mTc-annexin A5 as an atherosclerosis imaging tracer in a rabbit model (myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits; WHHLMI rabbits) of spontaneous atherosclerosis.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Molecular Imaging of Atherosclerosis for Improving Diagnostic and Therapeutic Development
Thibaut Quillard,Peter Libby +1 more
TL;DR: The current status of molecular imaging approaches that target the key processes implicated in plaque formation, development, and disruption are summarized and how the refinement and application of such tools might aid the development and evaluation of novel therapeutics are highlighted.
120
Targeting of Lectinlike Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) with 99mTc-Labeled Anti–LOX-1 Antibody: Potential Agent for Imaging of Vulnerable Plaque
Seigo Ishino,Takahiro Mukai,Yuji Kuge,Noriaki Kume,Mikako Ogawa,Nozomi Takai,Junko Kamihashi,Masashi Shiomi,Manabu Minami,Toru Kita,Hideo Saji +10 more
TL;DR: Nuclear imaging of LOX-1 expression with 99mTc-LOX- 1-mAb may be a useful means for predicting atheroma at high risk for rupture.
97
2P-504 Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit)
TL;DR: This is the first report of spontaneous myocardial infarction in rabbits, and it is suggested that this WHHLMI rabbit strain will be a useful animal model to study human my Cardiac Infarction.
97
Molecular Imaging of Inflammation in Atherosclerosis
TL;DR: The potential of established and new molecular imaging technologies in the setting of atherosclerosis are reviewed, and the cumbersome steps required for translating molecular imaging approaches into the clinic are discussed.
Molecular imaging in atherosclerosis
Andor W. J. M. Glaudemans,Riemer H. J. A. Slart,Alessandro Bozzao,Elena Bonanno,Marcello Arca,Rudi Dierckx,Rudi Dierckx,Alberto Signore,Alberto Signore +8 more
TL;DR: This emerging area of nuclear imaging techniques can provide measures of biological activity of atherosclerotic plaques, thereby improving the prediction of clinical events, and is expected to be developed in the next few years.
60
References
A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
H. C. Stary,A. B. Chandler,R. E. Dinsmore,Valentin Fuster,S. Glagov,William Insull,M. E. Rosenfeld,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The histological classification of human atherosclerotic lesions found in the second part of this report led to the earlier definitions of precursor lesions, and the appearance of lesions noted in clinical imaging studies with histological lesion types and corresponding clinical syndromes was attempted.
3.9K
Coronary Plaque Disruption
TL;DR: This review will explore potential mechanisms responsible for the sudden conversion of a stable atherosclerotic plaque to an unstable and life-threatening atherothrombotic lesion—an event known as plaque fissuring, rupture, or disruption.
3.7K
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary,A. B. Chandler,S. Glagov,John R. Guyton,W Insull,M. E. Rosenfeld,S A Schaffer,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.
1.6K
Imaging Atherosclerotic Plaque Inflammation With [18F]-Fluorodeoxyglucose Positron Emission Tomography
James H.F. Rudd,Elizabeth A. Warburton,Tim D. Fryer,Hazel A. Jones,John C. Clark,Nagui M. Antoun,Peter Johnström,Anthony P. Davenport,Peter J. Kirkpatrick,B.N. Arch,John D. Pickard,P. L. Weissberg +11 more
TL;DR: It is demonstrated that atherosclerotic plaque inflammation can be imaged with 18 FDG-PET, and that symptomatic, unstable plaques accumulate more 18FDG than asymptomatic lesions.
1.3K
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary,A. B. Chandler,S. Glagov,John R. Guyton,W Insull,M. E. Rosenfeld,S A Schaffer,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.
944