Journal Article10.1016/S0300-595X(83)80044-9
4Diabetic ketoacidosis — pathogenesis, prevention and therapy
David S. Schade,R. Philip Eaton +1 more
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TL;DR: The majority of complications encountered during the treatment of diabetic ketoacidosis are avoidable if proper care and attention is provided by the physician, and the use of low-dose insulin therapy, rehydration with isotonic saline, and aggressive potassium replacement is favoured.
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About: This article is published in Clinics in Endocrinology and Metabolism. The article was published on 01 Jul 1983. The article focuses on the topics: Diabetic ketoacidosis & Ketoacidosis.
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Citations
Management of Hyperglycemic Crises in Patients With Diabetes
Abbas E. Kitabchi,Guillermo E. Umpierrez,Mary Beth Murphy,Eugene J. Barrett,Robert A. Kreisberg,John I. Malone,Barry M. Wall +6 more
TL;DR: Treatment of patients with DKA and HHS uses significant health care resources, which increases health care costs.
713
Can Serum β-Hydroxybutyrate Be Used to Diagnose Diabetic Ketoacidosis?
Mae Sheikh-Ali,Brad S. Karon,Ananda Basu,Yogish C. Kudva,Lisa Muller,Jia Xu,W. Frederick Schwenk,John M. Miles +7 more
TL;DR: Serum beta-hydroxybutyrate levels in the presence of uncontrolled diabetes can be used to diagnose DKA and may be superior to the serum HCO(3) level for that purpose.
170
Persisting mortality in diabetic ketoacidosis.
TL;DR: An overall hospital mortality rate of 3.9% was found in 929 episodes of diabetic ketoacidosis treated in single centre over a 21‐year period, and many of the residual deaths occurred in elderly patients with such medical illness in addition to the keto Acidosis.
146
Differential effects of fasting and dehydration in the pathogenesis of diabetic ketoacidosis.
TL;DR: The data suggest that fasting and dehydration have differential effects on glycemia during insulin deficiency, with dehydration favoring the development of hyperglycemia and fasting resulting in reduced glucose concentrations.
74
Impact of a critical pathway on inpatient management of diabetic ketoacidosis
Liza L. Ilag,Steven L. Kronick,Robert D. Ernst,Louise Grondin,Cesar Alaniz,Lei Liu,William H. Herman +6 more
TL;DR: Implementation of a DKA critical pathway reduced practice variation and was associated with shorter LOS and a trend toward decreased cost, and some processes of care were improved but many require additional interventions.
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References
Pathogenesis of Diabetic Ketoacidosis: A Reappraisal
David S. Schade,R P Eaton +1 more
TL;DR: The data suggest that diabetic ketoacidosis may be prevented by correcting either the relative deficiency of insulin or the excess secreation of one or a combination of the stress hormones.
Dose Response to Insulin in Man: Differential Effects on Glucose and Ketone Body Regulation
David S. Schade,R. Philip Eaton +1 more
TL;DR: This prospective study was undertaken to elucidate the relationship between progressive log increments in plasma free insulin concentration and the resultant changes in the concentrations of plasma glucose, potassium, ketones, and free fatty acids in man.