Journal Article10.1002/ADHM.202001922
3D-Printed Hydrogel-Filled Microneedle Arrays.
Lindsay Barnum,Lindsay Barnum,Jacob Quint,Jacob Quint,Hossein Derakhshandeh,Mohamadmahdi Samandari,Mohamadmahdi Samandari,Fariba Aghabaglou,Ali Farzin,Laleh Abbasi,Sidi A. Bencherif,Sidi A. Bencherif,Adnan Memic,Adnan Memic,Pooria Mostafalu,Ali Tamayol,Ali Tamayol +16 more
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TL;DR: In this article, a low cost and simple, but robust, strategy employing microneedle arrays (MNAs) is developed, which is formed from a rigid outer layer, 3D printed onto a conformal backing, and filled with drug-eluting hydrogels.
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Abstract: Microneedle arrays (MNAs) have been used for decades to deliver drugs transdermally and avoid the obstacles of other delivery routes Hydrogels are another popular method for delivering therapeutics because they provide tunable, controlled release of their encapsulated payload However, hydrogels are not strong or stiff, and cannot be formed into constructs that penetrate the skin Accordingly, it has so far been impossible to combine the transdermal delivery route provided by MNAs with the therapeutic encapsulation potential of hydrogels To address this challenge, a low cost and simple, but robust, strategy employing MNAs is developed These MNAs are formed from a rigid outer layer, 3D printed onto a conformal backing, and filled with drug-eluting hydrogels Microneedles of different lengths are fabricated on a single patch, facilitating the delivery of various agents to different tissue depths In addition to spatial distribution, temporal release kinetics can be controlled by changing the hydrogel composition or the needles' geometry As a proof-of-concept, MNAs are used for the delivery of vascular endothelial growth factor (VEGF) Application of the rigid, resin-based outer layer allows the use of hydrogels regardless of their mechanical properties and makes these multicomponent MNAs suitable for a range of drug delivery applications
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Citations
Alzheimer’s Disease: Treatment Strategies and Their Limitations
Elodie Passeri,Kamil Elkhoury,Margaretha Morsink,Kerensa Broersen,Michel Linder,Ali Tamayol,Catherine Malaplate,Frances T. Yen,Elmira Arab-Tehrany +8 more
TL;DR: In this article , the authors present an update on the clinical and physiological phase of the Alzheimer's disease spectrum, modifiable and non-modifiable risk factors for AD treatment with a focus on prevention strategies, then research models used in AD, followed by a discussion of treatment limitations.
Multimodal Sensing and Therapeutic Systems for Wound Healing and Management: A Review
Shao-Hao Lu,Mohamadmahdi Samandari,Caihong Li,Huijie Li,Dongsheng Song,Yi Zhang,Ali Tamayol,Xueju Wang +7 more
TL;DR: In this paper , a review of multimodal sensing and therapeutic systems for wound healing is presented, focusing on physical sensing (temperature, moisture, pressure, and strain), chemical sensing (pH, uric acid, and cytokine), and leveraging advanced analytic techniques, i.e., machine learning and deep learning, for data-driven assessment and management of the wound healing process has been discussed.
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Design principles of microneedles for drug delivery and sampling applications
Zhicheng Le,Jinming Yu,Ying Jie. Quek,Bingyu Bai,Xianlei Li,Yufeng Shou,Ba Myint,Chenjie Xu,Andy Tay +8 more
TL;DR: In this article , the design principles of microneedles to overcome the biological barriers of various administration routes for drug delivery, in addition to more recent innovations employing micro-droneedles for biomolecular and cellular sampling applications.
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Personalized and Programmable Microneedle Dressing for Promoting Wound Healing.
TL;DR: Wang et al. as mentioned in this paper presented a novel wound dressing with superfine needle tips, personalized pattern design, programmable needle length, and multiple mechanical strengths for intelligent and painless drug delivery.
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Strategies to develop polymeric microneedles for controlled drug release
Bo Zhi Chen,Yu Ting He,Ze Qiang Zhao,Yun Hao Feng,Ling Liang,Juan Peng,Chen Yu Yang,Hiroshi Uyama,Mohammad-Ali Shahbazi,Xin Dong Guo +9 more
TL;DR: This review critically examines polymeric microneedle systems for controlled drug release, focusing on design strategies for temporally controlled and locally targeted release, and explores the potential and challenges of translating these systems into next-generation therapies.
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Pierre Villard,Pierre Villard,Mahboobeh Rezaeeyazdi,Thibault Colombani,Kasturi Joshi-Navare,Devyesh Rana,Adnan Memic,Sidi A. Bencherif +7 more
TL;DR: The results further demonstrate the huge potential of cryogels in the biomedical field and their capacity to be translated into clinical applications.
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One-step wettability patterning of PDMS microchannels for generation of monodisperse alginate microbeads by in Situ external gelation in double emulsion microdroplets
Mohamadmahdi Samandari,Mohamadmahdi Samandari,Fatemeh Alipanah,Shaghayegh Haghjooy Javanmard,Amir Sanati-Nezhad +4 more
TL;DR: A new droplet-based microfluidic strategy is developed for cell and chip friendly fabrication of monodispersed alginate microbeads, which offers both biocompatibility as a result of external gelation and rapid recovery of beads from processing solutions, as well as chip-compatibility due to clog-free gelation.
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Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery.
Jing Tu,Guangsheng Du,M. Reza Nejadnik,Juha Mönkäre,Koen van der Maaden,Paul H. H. Bomans,Nico A. J. M. Sommerdijk,Bram Slütter,Wim Jiskoot,Joke A. Bouwstra,Alexander Kros +10 more
TL;DR: Microneedle arrays coated with LB-MSN-OVA were successfully developed and shown to be suitable for intradermal delivery of the encapsulated protein antigen.
Miniaturized Needle Array-Mediated Drug Delivery Accelerates Wound Healing.
Mohamadmahdi Samandari,Fariba Aghabaglou,Kristo Nuutila,Hossein Derakhshandeh,Yuteng Zhang,Yori Endo,Seth Harris,Lindsay Barnum,Craig Kreikemeier-Bower,Elmira Arab-Tehrany,Nicholas A. Peppas,Indranil Sinha,Ali Tamayol,Ali Tamayol +13 more
TL;DR: In this paper, the authors explored the importance of specialty delivery systems in controlling wound bed drug distribution and consequently improving wound healing rate and quality, and evaluated the benefits of VEGF delivery using miniaturized needle arrays and liquid jet injectors.
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Breathable hydrogel dressings containing natural antioxidants for management of skin disorders.
Mattia Comotto,Mattia Comotto,Mattia Comotto,Saghi Saghazadeh,Saghi Saghazadeh,Sara Bagherifard,Sara Bagherifard,Sara Bagherifard,Bahar Aliakbarian,Mehdi Kazemzadeh-Narbat,Mehdi Kazemzadeh-Narbat,Fatemeh Sharifi,Fatemeh Sharifi,Seyed Ali Mousavi Shaegh,Seyed Ali Mousavi Shaegh,Seyed Ali Mousavi Shaegh,Elmira Arab-Tehrany,Nasim Annabi,Nasim Annabi,Nasim Annabi,Patrizia Perego,Ali Khademhosseini,Ali Tamayol,Ali Tamayol,Ali Tamayol +24 more
TL;DR: Alginate dressings are functionalized with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial and the hydrogel maintains excellent mechanical properties and oxygen permeability over time.