Journal Article10.1021/ES961067I
3-Nitrobenzanthrone, a Powerful Bacterial Mutagen and Suspected Human Carcinogen Found in Diesel Exhaust and Airborne Particulates
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TL;DR: 3-Nitrobenzanthrone (3-nitro-7H-benz[d,e]anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles and was identified as a new class of powerful direct mutagen as discussed by the authors.
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Abstract: 3-Nitrobenzanthrone (3-nitro-7H-benz[d,e]anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles and was identified as a new class of powerful direct mutagen. Its mutagenicity by Ames Salmonella assay is very high (208 000 revertants/nmol in Salmonella typhimurium TA98 and 6 290 000 revertants/nmol in YG1024) and compares with that of 1,8-dinitropyrene, which is the direct mutagen of strongest activity (257 000 revertants/nmol in TA98 and 4 780 000 revertants/nmol in YG1024) so far reported in the literature. The new mutagen was also shown to induce micronuclei in mouse peripheral blood reticulocytes after intraperitoneal administration (micronucleated reticulocytes, 0.64% against 25 mg/kg dose after 48 h), suggesting its potential genotoxicity to mam malians. 3-Nitrobenzanthrone is most likely to be formed not only during the combustion process of fossil fuels but also from the atmospheric reaction between benzanthrone and lower oxides of nitrogen, since the ...
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Citations
Carcinogenic Polycyclic Aromatic Hydrocarbons
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TL;DR: In this paper, the carcinogenic effects of polycyclic aromatic hydrocarbons (PAHs) derivatives (nitro-, alkyl-, and oxy-PAH derivatives) were investigated.
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TL;DR: The multiyear variations showed downward trends for a number of targeted compounds, suggesting that on-going emission reductions of PAHs are effective also for co-emitted NPAHs and OPAhs.
Simultaneous analysis of oxygenated and nitrated polycyclic aromatic hydrocarbons on standard reference material 1649a (urban dust) and on natural ambient air samples by gas chromatography–mass spectrometry with negative ion chemical ionisation
TL;DR: These preliminary results show a good correlation between the characteristics of the sampling site and the compound origins (primary or secondary) of the compounds present at low concentrations in the atmosphere.
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TL;DR: Diesel exposure led to an increase of PAH metabolism in the workers examined, most probably by an induction of cytochrome P450.
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