Journal Article10.1021/ES961067I
3-Nitrobenzanthrone, a Powerful Bacterial Mutagen and Suspected Human Carcinogen Found in Diesel Exhaust and Airborne Particulates
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TL;DR: 3-Nitrobenzanthrone (3-nitro-7H-benz[d,e]anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles and was identified as a new class of powerful direct mutagen as discussed by the authors.
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Abstract: 3-Nitrobenzanthrone (3-nitro-7H-benz[d,e]anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles and was identified as a new class of powerful direct mutagen. Its mutagenicity by Ames Salmonella assay is very high (208 000 revertants/nmol in Salmonella typhimurium TA98 and 6 290 000 revertants/nmol in YG1024) and compares with that of 1,8-dinitropyrene, which is the direct mutagen of strongest activity (257 000 revertants/nmol in TA98 and 4 780 000 revertants/nmol in YG1024) so far reported in the literature. The new mutagen was also shown to induce micronuclei in mouse peripheral blood reticulocytes after intraperitoneal administration (micronucleated reticulocytes, 0.64% against 25 mg/kg dose after 48 h), suggesting its potential genotoxicity to mam malians. 3-Nitrobenzanthrone is most likely to be formed not only during the combustion process of fossil fuels but also from the atmospheric reaction between benzanthrone and lower oxides of nitrogen, since the ...
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Citations
NMR Spectroscopy and Molecular Orbital Calculations to Interpret the Mutagenicity of Nitrobenzanthrones
TL;DR: In this paper, a thorough NMR measurements were made on 3-nitro-7H-benz[d, e]anthracen-7-one (1), 1,9-dinitro-6H-Benz[D,e]anthrasen-1 (2), 3-11-din-nitro-1H-H-BENZ[d] (3,11]-7Hbenz [d,e]-anthracens 7-one, and 11-nite-7h-
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Erratum to: S-(3-Aminobenzanthron-2-yl)cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-nitrobenzanthrone, a potent environmental carcinogen.
TL;DR: 3-ABA-Cys is the first example of arylnitrenium-cysteine adduct in globin representing a new promising class of biomarkers to assess cumulative exposures to aromatic amines, nitroaromatics and heteroaromatic amines.
•Dissertation
The concentrations, behaviour and fate of polycyclic aromatic hydrocarbons (PAHs) and their oxygenated and nitrated derivatives in the urban atmosphere
Ian James Keyte
- 01 Jul 2015
TL;DR: In this article, the airborne concentrations of polycyclic aromatic hydrocarbons (PAHs), OPAH and NPAH compounds in U.K. atmosphere at heavily trafficked and urban background sites were investigated.
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Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells.
Anthony L. Su,B. Penning +1 more
TL;DR: In this article , a combination of pharmacological and genetic approaches were used to assess the relative importance of these enzymes and NRF2 in the aerobic nitroreduction of 1-NP in human bronchial epithelial cells, A549 and HBEC3-KT.
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Analysis of the metabolic transformation of mutagenic nitrobenzobenzanthrones by molecular orbital calculations
TL;DR: In this article, the mutagenic activity of three nitrobenzobenzanthrones (NBBAs) and two dinitrobenzanthrone (DNBBAs), was found to depend largely on the position and the number of the nitro groups as well as that of NBBAs.
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References
Mutagenicity and Carcinogenicity of Nitroarenes and Their Sources in the Environment
TL;DR: The incidence and histological features of tumors induced by nitroarenes are described, and the possible association between human lung cancer and nitrorenes is discussed, and speculation on the risk of nitroAREnes for humans is presented.
493
The formation of nitro-PAH from the gas-phase reactions of fluoranthene and pyrene with the OH radical in the presence of NOx
TL;DR: In this paper, the products of the gas phase reactions of the OH radical with fluoranthene and pyrene in the presence of NOx have been studied in a ~6400l environmental chamber.
316
The genetic toxicity of human carcinogens and its implications
TL;DR: Findings show that genetic toxicity is characteristic of the majority of IARC Group 1 human carcinogens and if these chemicals are considered representative of human carcinangers, then two short-term tests may serve as an effective primary screen for chemicals that present a carcinogenic hazard to humans.
199
Surface predominance of trace elements in airborne particles.
TL;DR: A number of minor and trace elements including Be, C, Ca, Cr, K, Li, Mn, Na, P, Pb, S, Tl, V and Zn present in coal fly ash are found to be preferentially concentrated on the particle surfaces.
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