23Na MR Imaging at 7 T after Knee Matrix–associated Autologous Chondrocyte Transplantation Preliminary Results
Siegfried Trattnig,Goetz H. Welsch,Vladimir Juras,Pavol Szomolanyi,Marius E. Mayerhoefer,David Stelzeneder,Tallal C. Mamisch,Oliver Bieri,Klaus Scheffler,Stefan Zbýn +9 more
TL;DR: With the modified 3D GRE sequence at 7 T, a sufficiently high SNR in sodium images was achieved, allowing for differentiation of repaired tissue from native cartilage after MACT, and a strong correlation was found between sodium imaging and dGEMRIC in patients after Mact.
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Abstract: To evaluate the feasibility of sodium 7-T magnetic resonance (MR) imaging in repaired tissue and native cartilage of patients after matrix-associated autologous chondrocyte transplantation (MACT) and compare results with delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) at 3 T.
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Pros and cons of ultra-high-field MRI/MRS for human application.
Mark E. Ladd,Peter Bachert,Peter Bachert,Martin Meyerspeer,Ewald Moser,Armin M. Nagel,Armin M. Nagel,David G. Norris,David G. Norris,Sebastian Schmitter,Sebastian Schmitter,Oliver Speck,Sina Straub,Moritz Zaiss +13 more
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TL;DR: Examples are given to demonstrate the advantages of susceptibility‐weighted imaging, time‐of‐flight MR angiography, high‐resolution functional MRI, 1H and 31P MRSI in the human brain, sodium and functional imaging of cartilage and the first results using an eight‐channel body array, suggesting future areas of research should be intensified in order to fully explore the potential of 7‐T MR systems for use in clinical diagnosis.
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Thomas Baum,Gabby B. Joseph,Dimitrios C. Karampinos,Pia M. Jungmann,Thomas M. Link,Jan S. Bauer +5 more
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MRI at 7 tesla and above: Demonstrated and potential capabilities
TL;DR: This overview article focuses on already achieved advantages for in vivo imaging, i.e., in imaging the brain and joints of the musculoskeletal system, but also considers developments in body imaging, which is particularly challenging.
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TL;DR: In vivo clinical images of T1 in the presence of Gd(DTPA)2‐ (i.e., GAG distribution) correlated well with the validated ex vivo results after total knee replacement surgery, showing that it is feasible to monitor G AG distribution in vivo.
Autologous chondrocyte transplantation of the ankle.
TL;DR: The results are promising over a medium-length follow-up (2-6 years), and deeper involvement of the subchondral bone may need autologous bone grafting along with ACT.
Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T
TL;DR: A three‐dimensional T1 measurement technique that is suitable for delayed gadolinium (Gd)‐enhanced MRI of cartilage (dGEMRIC) and can be easily implemented with clinically available pulse sequences at 1.5T and 3.0T is implemented.
Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up.
Matthias Steinwachs,P. Kreuz +1 more
TL;DR: ACI is an effective method in the treatment of isolated cartilage defects in the knee and graft hypertrophy can be avoided by using a collagen membrane.
Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.
Gunnar Knutsen,Lars Engebretsen,Tom C. Ludvigsen,Jon Olav Drogset,Torbjørn Grøntvedt,Eirik Solheim,Torbjørn Strand,Sally Roberts,Vidar Isaksen,Oddmund Johansen +9 more
TL;DR: There was no significant difference in macroscopic or histological results between the two treatment groups and no association between the histological findings and the clinical outcome at the two-year time-point.