TL;DR: Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions.

TL;DR: A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.

TL;DR: This three-component radical cascade reaction allows an efficient synthesis of a range of perfluoroalkyl containing quinoxalin-2(1H)-one derivatives in moderate to excellent yields under mild conditions.

TL;DR: A photoinduced, phosphoranyl radical-mediated protocol for the direct N-O cleavage of strained cycloketone oximes via a polar/SET crossover process was developed for the first time, enabling facile accesses to a range of elongated cyano and/or gem-difluoroalkene-bearing compounds.

TL;DR: A nickel-catalyzed reductive cross-coupling of alkylpyridinium salts and aryl bromides has been developed using Mn as the reductant, and mechanisms indicate the formation of an alkyl radical.

TL;DR: This one-pot protocol could well be expanded to access various 2-fluoroalkylbenzoselenazoles starting from (2-isocyanophenyl)(methyl)selane, perfluoroALKyl iodides or ICF2COOEt and TMEDA.

TL;DR: Mechanistic studies are consistent with the formation of CF3-bound high oxidation state Mn species, suggesting a transition-metal-mediated CF3 transfer mechanism for this trifluoromethylation/C(sp2)-H functionalization process.

TL;DR: A green and efficient multicomponent reaction protocol to synthesize S-aryl dithiocarbamates under visible light that meets the requirements of sustainable and green synthetic chemistry.

TL;DR: This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions conditions and can be extended to the facile and efficient synthesis of histamine-4 receptor.

TL;DR: The electro-induced aminoselenation and oxyselenation of styrenes without any acids or oxidants as additives is reported and this transformation is compatible with various functional groups, which leads to vicinal difunctionalized organoselenium compounds.

TL;DR: A visible-light-promoted redox neutral γ,γ-difluoroallylation of cycloketone oxime ethers with trifluoromethyl alkenes through C-C and C-F bond cleavage has been achieved, which affords various cyano-substituted gem-d ifluoroalkenes in generally good yields.

TL;DR: The catalyst-free electrochemical di- and trifluoromethylation/cyclization of N-substituted acrylamides was realized under external oxidant-free conditions and provided strong support for a SET-based reaction manifold.

TL;DR: Herein, a novel fluorescent probe by integrating 4-azide-1,8-naphthalic anhydride and spiropyran was obtained and was capable of specifically monitoring H2S by azide reduced and was successfully used for detection of H 2S/SO2 in cells and mice.

TL;DR: Despite both strategies performing better than DP4, their combined use (i J/d J-DP4) provided the best results, with a 2.5-fold performance improvement at similar or lower computational cost.

TL;DR: Manganese-photocatalyzed activation of the Si-H bond in silanes for the hydrosilylation of alkynes has been developed, providing a wide range of Z-vinylsilanes in high yields.

TL;DR: Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N -arylindoles is reported and the crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed.

TL;DR: An approach for efficient synthesis of C-glycosyl amino acids is described, which follows a pathway in which α-imino esters serve as electrophiles in chemoselective addition reactions with nucleophilic glycosyl radicals.

TL;DR: A regioselective, intermolecular 1,2-alkylarylation of alkenes with aryl halides and alkyl oxalates has been developed via photoredox/nickel dual catalysis, where radical addition is followed by a nickel-assisted coupling, forging two consecutive C-C bonds in a single operation.

TL;DR: This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

TL;DR: This multicomponent reaction of O-acyl oximes, potassium metabisulfite, alkenes, and nucleophiles under visible-light irradiation is efficient, giving rise to a range of sulfones in moderate to good yields.

TL;DR: This undivided cell one-pot method enables C-C bond formation using inexpensive, benchtop-stable reagents with isolated yields up to 95% with good functional group tolerance, which includes nitrile, ketone, ester, alkene and selectivity over other aromatic halogens.

TL;DR: By merging C-F and C-C bond activation in the cross-electrophile coupling, this Ni-catalyzed reaction is bestowed with broad substrate scope, low catalyst loading, complete regioselectivities, and high tolerance of a wide range of sensitive functional groups.

TL;DR: A one-pot synthetic strategy for the synthesis of 2-alkylaminoquinolines through sequential dehydrogenative annulation and N-alkylation reaction has also been demonstrated.

TL;DR: This work reports the first selective synthesis of 2,2-difluorobicyclo[1.1. 1.1]pentanes via diffluorocarbene insertion into bicyclo[ 1.2.0]butanes via similar mechanisms and should inspire future studies on synthesis of other "ortho/meta-substituted" BCPs via similar mechanism.

TL;DR: The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported, providing strong evidence for the in situ formation of putative high valent Au(III) intermediates.

TL;DR: A novel ruthenium-catalyzed [5 + 1] annulation of 2-alkenylanilines with sulfoxonium ylides was developed for the rapid assembly of highly functionalized quinolines and could be obtained with good yields and excellent functional group tolerance.

TL;DR: A resource saving protocol for the synthesis of 5-fluoromethyl-2-oxazolines by using electrochemistry offering a sustainable alternative over conventional reagent-based pathways is realized.

TL;DR: A carbon nitride material can be combined with homogeneous nickel catalysts for light-mediated cross-couplings of aryl bromides with alcohols under mild conditions and the application for intramolecular reactions and the synthesis of active pharmaceutical ingredients was demonstrated.

TL;DR: A method where Selectfluor can promote the oxidative C(sp3)-H arylation with heteroarenes without external photocatalysis under visible-light irradiation is proposed.