Oncology Progress 

Abstract: Objective To investigate the clinical efficacy and safety of ginsenoside Rg3 maintenance therapy after the first-line chemotherapy for patients with advanced non-small cell lung cancer(NSCLC).Method A total of 69 patients who responded to the first-line chemotherapy were assigned to single-agent ginsenoside Rg3 maintenance therapy or clinical observation.The maintenance therapy continued until disease progresses or intolerable toxicity occurs.Result 2 patients in treatment group withdrew or lost follow-up,the ratio of progression in maintenance therapy group and observation group were 53.1%vs 62.9%and the median progression-free survival time were,6.5 months us 6.2 months,respectively,both of the two indexes were not significantly different(P 0.05),though there was significant difference in the elevation of T lymphocyte subset and life quality(P 0.05),and there were also more patients in maintenance group received second-line therapy after tumor progressed(P 0.05).Conclusion Maintenance therapy of ginsenoside Rg3 is an effective treatment option for patients with advanced NSCLC who have not progressed after first-line therapy,and is well tolerated.

Abstract: Objective The HPV infection rate and distribution of high-risk type in Chinese women of different regions were analyzed to provide basic scientific data for the development of effective regional control strategies and the development of HPV vaccine.Method By searching the literature,associated researches published in China before July 2011 were analyzed and evaluated comprehensively.Result HPV infection rate is 15.71%in ordinary women,and is lower than cervical lesions(15.71%vs 82.43%,P 0.05 ).Average infection rate of high-risk type is higher in northern China than in southern China(41.57%vs 14.81%,P 0.05).Average infection rate of high-risk type is higher in minority autonomous regions than others(56.36%vs 17.11%,P 0.05).The 6 most common HPV types in China are HPV-16, HPV-52,HPV-58,HPV-33,HPV-32,and HPV-31,with HPV-16 being the most frequently observed one among all types.The distribution of other common types in different regions varies.Conclusion The HPV infection rate and the distribution of high-risk type vary in different regions and diverse populations.HPV-16,HPV-52,HPV-58 are dominant infection types which are specific in China.

Abstract: Objective To explore the related factors of reactivation of hepatitis B virus induced by three dimensional conformal radiotherapy(3D-CRT) in primary hepatic carcinoma. Method Fifty-six patients with primary liver cancer who were administered with 3D-CRT therapy were enrolled. Based on whether the antiviral treatment was followed by radiotherapy, all patients were divided into two groups. Group A(with following antiviral treatment group):32 cases; group B(without following antiviral treatment): 24 cases. Statistical analysis was carried out, including HBV reactivation rates and risk factors for HBV reactivation, HBV reactivation induced hepatitis, elevated ALT and liver function damage degree, and the incidence of RILD. Result In the 12 th week after 3D- CRT treatment, totalHBV reactivation rates of group A was lower than that of group B, with statistically significant difference(P0.05);The two groups had similar proportion of cases with doubled ALT level(P0.05). The incidence of reactivation induced hepatitis in group A(6.25%) is significantly lower than that of group B(25.0%)(P0.05); and liver function damage degrees in both groups were similar(P0.05), so were the incidence of RILD(6.25 vs 16.67%; χ2=1.5556, P=1.5556). In respect of HBV reactivation and inactivation, Child-Pugh, hierarchical structure and HBV DNA level, the two groups had statistically significant difference(P0.05). Conclusion 3D- CRT technology is an important treatment for advanced liver cancer, of which the HBV reactivation and RILD are common complications; antiviral treatment can reduce the HBV reactivation rate and the incidence of HBV reactivation induced hepatitis after 3D- CRT treatment.