Showing papers in "Medicine in 2016"
TL;DR: HPV infection may not be of prognostic utility in the evaluation of factors contributing to esophageal cancer, and large prospective studies are encouraged to stratify survival analysis by HPV type.
2,754 citations
TL;DR: Although rare, this diagnosis is worth knowing, as specific treatment has to be started as soon as possible and proved to be efficient in this case as well as in other reports in the literature.
1,930 citations
TL;DR: Once-daily STR with RPV/FTC/TDF as a once-daily single-tablet regimen may be a safe and effective choice in selected HIV-1-infected adolescents and children.
1,008 citations
TL;DR: A systematic review and meta-analysis aimed to compare the discriminative ability of Child–Pugh versus MELD score to assess the prognosis of cirrhotic patients and found that their benefits might be heterogeneous in some specific conditions.
439 citations
TL;DR: Sarcopenia is an independent predictive factor of severe postoperative complications after radical gastrectomy for gastric cancer and is independently associated with overall and disease-free survival in patients with TNM stage II and III, but not in patientsWith TNM stages II and I, and under the adjusted tumor-node-metastasis (TNM) stage.
420 citations
TL;DR: This nationwide population-based cohort study provides evidence that patients with NASDs are at higher risk of developing acute kidney injury (AKI) than people without NASDs.
Abstract: AbstractNonapnea sleep disorders (NASDs) and associated problems, which are highly prevalent in patients with kidney diseases, are associated with unfavorable medical sequelae. Nonetheless, whether NASDs are associated with acute kidney injury (AKI) development has not been thoroughly analyzed. We examined the association between NASD and AKI.We conducted a population-based study by using 1,000,000 representative data from the Taiwan National Health Insurance Research Database for the period from January 1, 2000, to December 31, 2010. We studied the incidence and risk of AKI in 9178 newly diagnosed NASD patients compared with 27,534 people without NASD matched according to age, sex, index year, urbanization level, region of residence, and monthly income at a 1:3 ratio.The NASD cohort had an adjusted hazard ratio (hazard ratio [HR]; 95% confidence interval [CI] = 1.15–2.63) of subsequent AKI 1.74-fold higher than that of the control cohort. Older age and type 2 diabetes mellitus were significantly associated with an increased risk of AKI (P < 0.05). Among different types of NASDs, patients with insomnia had a 120% increased risk of developing AKI (95% CI = 1.38–3.51; P = 0.001), whereas patients with other sleep disorders had a 127% increased risk of subsequent AKI (95% CI = 1.07–4.80; P = 0.033). Men with NASDs were at a high risk of AKI (P < 0.05).This nationwide population-based cohort study provides evidence that patients with NASDs are at higher risk of developing AKI than people without NASDs.
383 citations
TL;DR: Several different approaches to treatment aimed at overcoming the intrinsic resistance of CSCs to conventional therapies are currently being developed, including agents targeting tumorigenic pathways, and immunotherapies, including vaccines and natural killer cells employed to induce a T cell response.
380 citations
TL;DR: The 5STS test reliably predicts a poor 6MWT, especially when using ordinal data, and the 4MGS test is reliable when measured with continuous data.
372 citations
TL;DR: It is suggested that ICU professionals may suffer from a high level of burnout, potentially threatening patient care and future work should address the effective management of the factors negatively affecting ICu professionals.
300 citations
TL;DR: CSCs are a relatively rare population of cancer cells capable of self-renewal, differentiation, and generation of serially transplantable heterogeneous tumors of several types of cancer.
296 citations
TL;DR: High prevalences of mental disorders in the CWS were reported, which highlights the need for the provision of qualified service and the substantial heterogeneity of the findings is indicative of theneed for accurate epidemiological data to effectively guide public policy.
TL;DR: The threshold for optimal adherence to achieve better virologic outcomes appears to be wider than the commonly used cut-off point (≥95% adherence), which could be redefined to a slightly lower level to encourage the prescribing ART at an early stage of HIV infection.
TL;DR: Clinical characteristics of immune thrombocytopenia (ITP) subsets associated with autoimmune diseases (AIDs) are clarified to have a better understanding of pathogenesis of ITP and a better management of ITC patients.
TL;DR: The results support the evaluation of BRCA mutational status in patients with high risk of harboring BRCa germline mutations to better define the prognosis of breast cancer in these patients.
TL;DR: This review presents the results of articles relevant to age-related macular degeneration (AMD), diabetic retinopathy (DR), and OCT-A, a new promising method that allows the visualization of the retinal vascular network and the counting of blood flow parameters.
TL;DR: A 2-week nitazoxanide-based regimen is an effective and safe rescue therapy in Egyptian patients whose previous standard triple therapy has failed.
TL;DR: In this paper, the authors performed a meta-analysis to investigate whether Chlamydia trachomatis infection increases the risk of cervical cancer and found that individuals infected with C. trachmatis have a higher risk of cancer.
TL;DR: Increased understanding of the factors that create and contribute to tumor heterogeneity may support the design of therapies that affect CSC function and their microenvironments.
TL;DR: Overall, PCOS in pregnancy was associated with greater risk of GDM, preeclampsia, PIH, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death, and subgroup analysis suggested that these associations might be influenced by study design and pre-BMI.
TL;DR: An easy to use diagnostic scoring tool for NHL development in the context of SS is presented, and this model is highly significant for the design of early therapeutic interventions in high risk SS patients for NHLDevelopment.
TL;DR: Compared to non-TNBC, TNBC is larger and higher grade, but less likely to have lymph node metastases, and in a multivariable analysis controlling for tumor size and grade, T NBC was associated with significantly less node-positivity.
TL;DR: The increased risk of MI and coronary death associated with depression was consistent using modified inclusion criteria, across most subgroups, and after adjusting for possible publication bias.
TL;DR: It is concluded that humoral, nonspecific immunity (phagocytic activity and oxidative burst), and the IL-6 are influenced in patients with iron deficiency anemia.
TL;DR: IgG4-RD is a distinctive, unique, and treatable cause of large-vessel vasculitis that can also involve blood vessels secondary to perivascular tumefactive lesions and respond well to B cell depletion therapy.
TL;DR: The findings based on population-based cohort studies indicate that diabetes is associated with increased PD risk by about 38%.
TL;DR: Male sex and substantial proteinuria are significant perpetuating factors for the progression from late stage CKD to ESRD, and diabetes may play a minor role for the outcome of ESRd among patients with later stages of CKD.
TL;DR: It is indicated that overweight is associated with a lower risk of all-cause mortality among patients with COPD whereas underweight isassociated with a higher risk ofall-cause death in these patients.
TL;DR: Based on current evidence, smoking, disc protrusion, and diabetes were predictors for rLDH and patients with these risk factors should be paid more attention for prevention of recurrence after primary surgery.
TL;DR: The first large-scale study among the healthy population to find out the prevalence rate of pancreatic cystic neoplasms in asymptomatic healthy adults is reported; the age- and sex-adjusted prevalence was 2.2%, and increased with age.