Showing papers in "Journal of Polymer Research in 2025"
TL;DR: This review paper integrates AI and ML to optimize NFP/PLA composite development, covering material characterization, manufacturing, property prediction, durability assessment, sustainability analysis, and future perspectives, advancing eco-friendly materials for various applications.
Abstract: Natural Fibre Polymer (NFP) and Polylactic Acid (PLA) composites have received a lot of interest in a variety of sectors because they are environmentally friendly, renewable, and sustainable. Over the last decade, researchers have investigated the aspects of NFP/PLA composite development and optimization for a wide range of applications, including packaging materials, automotive components, construction materials, textile and apparel, biomedical devices, agricultural and horticultural applications, electronics, and consumer electronics. Furthermore, using Artificial Intelligence (AI) and Machine Learning (ML) methodologies has increased these polymer materials and associated technologies in their search for new potential ways to further progress in NFP and PLA composites. The purpose of this review paper is to present a complete overview of AI and machine learning applications in the synthesis and development of NFP/PLA composite materials. The subject matter includes the following research areas: material characterization, manufacturing, property prediction, durability assessment, sustainability analysis, and future perspectives, which demonstrate the potential and challenges of AI/ML in advancing NFP/PLA composite materials and technologies.
7 citations
4 citations
TL;DR: Researchers developed pH-sensitive nanocarriers using poloxamer 407-conjugated gelatin to deliver paclitaxel, a hydrophobic anticancer drug, with controlled release and biocompatibility, showing potential for improved cancer treatment efficacy and reduced side effects.
Abstract: Abstract Chemotherapy is one of the most prevalent and efficacious treatments for a wide variety of cancers; however, chemotherapeutic agents have clinically limited applications due to their low water solubility and risk of side effects. Nanomedicine can help to easily deliver hydrophobic and hydrophilic agents for cancer treatment. Here, we describe a nanocarrier system that enables the sustainable and controllable release of hydrophobic anticancer drugs, Paclitaxel, based on poloxamer 407-conjugated gelatin (GeP) copolymers. The particle size, zeta potential, morphology, and thermal stability of the nanogels were characterized. The successful synthesis of nanogels was confirmed by analyzing their chemical components. Among the GePs at different amounts of poloxamer 407, a ratio of gelatin and poloxamer (Ge:P) at 1:15 for preparation resulted in the nanogels being positive in charge, spherical in shape, and 97.84 ± 2.94 nm in hydrodynamic diameter (Dh), with optimal drug-carrying efficacy. The in vitro drug release from nanogels was accelerated in the tumor microenvironment at pH 5.5 in comparison to pH 7.4, and the drug release kinetics from nanogels were due to Fickian diffusion. Finally, the cytotoxicity assays indicated that GePs were biocompatible nanocarriers without toxicity on both normal (VERO) and breast cancer cell (MCF-7) lines, which could improve the pharmacokinetics and pharmacodynamics of paclitaxel. Overall, these results revealed an optimal ratio (1:15) of Ge:P for the synthesis of pH-responsive hybrid nanogels for sufficient paclitaxel releasement to kill MCF-7 for effective cancer treatment.
2 citations
1 citations