TL;DR: Patients with Peutz-Jeghers syndrome are at very high relative and absolute risk for gastrointestinal and nongastrointestinal cancers.

TL;DR: Colonic screening at 3-year intervals more than halves the risk of CRC, prevents CRC deaths, and decreases overall mortality by about 65% in HNPCC families.

TL;DR: Treatment with VSL#3 is effective in the prevention of the onset of acute pouchitis and improves quality of life of patients with ileal pouch-anal anastomosis.

TL;DR: 6-MP metabolite levels and TPMT genotyping may assist clinicians in optimizing therapeutic response to 6-MP and identifying individuals at increased risk for drug-induced toxicity.

TL;DR: A clinicobiological score combining age, BMI, triglycerides, and ALT had 100% negative predictive value for septal fibrosis when scoring 0 or 1 (100% sensitivity for a specificity of 47%).

TL;DR: There was a strong correlation between cancer risk and the size of the study, with small studies reporting much higher risks of cancer than larger studies, and publication bias may be overestimated in the literature due to publication bias.

TL;DR: Fecal calprotectin predicts clinical relapse of disease activity in patients with Crohn's disease and UC, whereas small intestinal permeability is a useful predictor of relapse in Patients with small intestinal CD.

TL;DR: Comparisons with previously reported HRQOL data for the general U.S. population and for patients with gastroesophageal reflux disease, diabetes mellitus, depression, and dialysis-dependent end-stage renal disease offer further insight into the impact of IBS on patient functional status and well-being.

TL;DR: In this paper, the abdominal withdrawal reflex and responses of viscerosensitive neurons were recorded during colon distention in a rat with either mechanical or chemical colonic irritation between postnatal days 8 and 21 and were tested when they became adults.

TL;DR: Inhibition of both COX-1 andCOX-2 is required for NSAID-induced gastric injury in the rat, and the combination of SC-560 and celecoxib invariably caused hemorrhagic erosion formation, comparable to that seen with indomethacin.

TL;DR: Addition of 6-MP to a regimen of corticosteroids significantly lessens the need for prednisone and improves maintenance of remission, and should be part of the initial treatment regimen for children with newly diagnosed moderate-to-severe CD.

TL;DR: Endoscopic mucosal resection of early carcinoma in Barrett's esophagus is associated with promisingly low morbidity and mortality rates and may offer a new minimally invasive therapeutic alternative to esophagectomy, especially in low-risk situations.

TL;DR: Assay of altered DNA holds promise as a stool screening approach for colorectal neoplasia, and sensitivities for cancer were unchanged but decreased slightly for adenomas, while specificity increased to 100%.

TL;DR: Twenty-seven percent of patients with CD and myelosuppression during azathioprine therapy had mutant alleles of the TPMT gene associated with enzyme deficiency, which is more often caused by other factors than other factors.

TL;DR: Findings support the unexpected conclusion that chronic hypergastrinemia in mice can synergize with Helicobacter infection and contribute to eventual parietal cell loss and progression to gastric cancer.

TL;DR: Bsep is identified as an important target for induction of drug- and estrogen-induced cholestasis in mammalian liver through ATP-dependent taurocholate transport in cLPM vesicles.

TL;DR: In this paper, Tissue transglutaminase, which has been identified as the highly specific endomysial autoantigen, is released from cells during inflammation, and it may potentiate antigen presentation by HLA-DQ2 and DQ8 by deamidating or cross-linking gluten peptides.

TL;DR: This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee and were approved by the committee on May 16, 1999 and by the AGA governing board on July 18, 1999.

TL;DR: Modeling and familial clustering suggest that SPINK1 mutations are disease modifying, possibly by lowering the threshold for pancreatitis from other genetic or environmental factors, but by themselves do not cause disease.

TL;DR: Subcutaneous rhuIL-10 administered daily for 28 days to patients with mild to moderately active Crohn's disease is safe, well-tolerated, and shows clinical and endoscopic improvement.

TL;DR: In patients with short-bowel syndrome, postabsorptive plasma citrulline concentration is a marker of functional absorptive bowel length and, past the 2-year adaptive period, a powerful independent indicator allowing distinction of transient from permanent intestinal failure.

TL;DR: Risk is dose dependent and is lower with ibuprofen at low doses than with other NSAIDs, and it is unlikely that Helicobacter pylori increases the risk, and under some circumstances it may be protective.

TL;DR: The results suggest that activated HSCs are targets of the vasoconstrictor action of ANGII in the intrahepatic circulation, and ANGII induces contraction and is mitogenic for human-activated H SCs by acting through AT1 receptors.

TL;DR: Wireless capsule endoscopy detected more abnormalities in the small bowel than push enteroscopy in detecting small-bowel lesions.

TL;DR: Subcutaneous treatment with rhuIL-10 over 28 days induced a fully reversible, dose-dependent decrease in hemoglobin and thrombocyte counts but no clinically significant side effects and up to 8 μg/kg of rhu IL-10 was well tolerated.

TL;DR: Tegaserod accelerates orocecal transit, tends to accelerate colonic transit, and deserves further study in patients with constipation-predominant IBS.