TL;DR: Patients' drug therapy immediately before entry to the study significantly affected subsequent response, and none of the drugs was superior to placebo in prophylaxis against flare-up or recurrence.

TL;DR: The values of the eight coefficients of the CDAI are rederived using data from 1058 visits of patients enrolled in the National Cooperative Crohn's Disease Study and the Trial of Adjunctive Sulfasalazine in Crohn’s Disease.

TL;DR: The purpose of this study was to characterize the collagen in normal liver and in liver cirrhosis of different etiology, and to determine whether the ratios of different collagen types vary with the agent that induced the disease.

TL;DR: The predicted factors associated with favorable outcome in placebo-treated patients were: previous surgical removal of all observable disease, absence of perianal disease, and Crohn's Disease Activity Index value under 200.

TL;DR: The purpose of this review will be to point out the clinical ramifications of the recent information, and suggest several areas where future investigation might prove fruitful in furthering the understanding of the pathophysiology and management of small intestine bacterial overgrowth.

TL;DR: The administration of indomethacin caused a significant fall in plasma renin activity, suggesting that endogenous prostaglandins exert more control over renin release than does ERPF, and appears to be an important factor in maintaining renal blood flow in patients with cirrhosis and sodium retention.

TL;DR: All three classes of antisecretory agents studied are also cytoprotective, i.e., they can protect against gastric mucosal injury by topical aspirin plus HCl by some mechanism other than inhibition of acid and pepsin secretion.

TL;DR: The frequent occurrence of intermediate types of motility disorders and the transition from diffuse spasm to achalasia suggest that achalAsia and diffuse esophageal spasm are part of a spectrum of related motor disorders.

TL;DR: This review describes how recent developments have sustained the expectation that by characterizing these substances, and their physiological actions upon the liver, a precise explanation of fundamental regulatory mechanisms would emerge.

TL;DR: The site of involvement of Crohn's disease is a major determinant of outcome after surgical intervention, and the data suggest a higher recurrence rate after the second surgery.

TL;DR: Results seem to suggest a possible role of the receptor on Dane particles (presently accepted hepatitis B virions) for polymerized albumin molecules in infecting hepatocytes both in humans and chimpanzees.

TL;DR: Evidence from this study that radiographic findings do not correlate with clinical symptoms or response, the ritual use of x-ray to follow patients with Crohn's disease is unnecessary.

TL;DR: It is suggested that angiodysplasia of the gastrointestinal tract can be regarded as a spectrum with a clearly inherited etiology on one extreme and an acquired etiology for a subset of patients associated with aortic valve disease.

TL;DR: There may be a certain metabolic state in the hepatocyte cell cycle that is most susceptible to the action(s) of ethanol; inhibition of liver regeneration by acute or chronic ethanol consumption may result in delayed recovery from prior or coincident liver injury.

TL;DR: The triolein breath test appears to be a sensitive, specific, noninvasive, and relatively simple screening test for the detection of steatorrhea.

TL;DR: The frequency of chronicity and its distribution according to epidemiologic background following acute non-A, non-B hepatitis was significantly higher following transfusion and among drug addicts than among patients without obvious source of infection.

TL;DR: The cases of 2 patients who died from cirrhosis after receiving perhexiline maleate, a drug widely used in Europe for the treatment of angina pectoris, are reported, consistent with the view that prolonged administration of per hexilinemaleate may induce both histologic lesions resembling those of alcoholic liver disease and ultrastructural and histochemical lesions resemblingThose of phospholipidosis.

TL;DR: Feces from normal subjects and patients with cerebrotendinous xanthomatosis were incubated anaerobically with labeled chenodeoxycholic acid and ursode oxygencholine acid for known periods, and the bile acids formed were analyzed by TLC and scintillation counting.

TL;DR: The procedure was performed as ultimate palliation in patients unfit for surgical insertion and had a low mortality rate of 2%.

TL;DR: Patients with chronic ulcerative colitis should have periodic rectal and colonoscopic biopsies, and those with moderate to marked dysplasia require colectomy because of the increased risk of colon carcinoma.

TL;DR: The study employed a scheme for double-blind evaluation of patient progress which allowed adjustment of prednisone dose according to the degree of illness and ensured continuous monitoring for serious toxicity of any study drug.

TL;DR: Cimetidine is a nonsteroidal-antiandrogen and this property may contribute to the production of gynecomastia in cimetidine-treated men, which is linked to the development of breast enlargement in men.

TL;DR: The phase relationships shown are consistent with a biphasic mechanism of stone growth in which calcium salts and lipid were alternately deposited and this sequence of calcium salt and cholesterol deposition occurred in the outer layers of some stones.

TL;DR: It is demonstrated that drugs with the highest hepatic clearance will have the largest relative increases in bioavailability in cirrhotic patients due to portosystemic shunting.

TL;DR: Fasting may decrease the inactivation of chemically reactive metabolites by glutathione, increase their binding to hepatic proteins, and enhance the hepatotoxicity of drugs transformed into chemically reactive metabolite that are detoxified by binding to glutATHione.

TL;DR: In this article, a double-blind, randomized, controlled trial to evaluate the effect of colchicine on liver cirrhosis, 43 patients were assigned to either a placebo (20 patients) or a colchicaline (23 patients) treatment group.

TL;DR: The serologic and tissue markers of hepatitis B virus (HBV) were studied in 50 patients in whom hepatocellular carcinoma (HCC) was confirmed at autopsy.

TL;DR: Observations indicate that Giardia cause brush border damage, which, is usually reversible with eradication of the parasite, and other factors, alone or in combination withGiardia, may be responsible for the cell damage beyond brush border injury found in some patients.

TL;DR: The effect of aluminum-magnesium hydroxide tablets (800 mg seven times per day) and that of sulpiride, a hypothalamic neurolaptic, were studied in 101 patients with duodenal ulcer in a double-blind controlled-4-week trial.