TL;DR: Current Protocols in Molecular Biology Title NLM.

TL;DR: The cyclic heptapeptide, microcystin‐LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with K i, values below 0.1 nM, and this results are strikingly similar to those obtained with the tumour promoter okadaic acid.

TL;DR: Application of this method to a large number of proteins has shown that this method can predict antigenic determinants with about 75% accuracy which is better than most of the known methods.

TL;DR: Laccase is capable of oxidizing both phenolic and non‐phenolic moieties of lignin but that the latter is dependent on the co‐presence of primary laccase substrates.

TL;DR: As the new superfamily included a well studied DNA and RNA helicase, T antigen of SV40, helicase function could be tentatively assigned also to the other related viral putative NTP‐binding proteins, the possibility of different and/or multiple functions for some of these proteins is discussed.

TL;DR: It was found that the modified oligo effectively suppresses the influenza A/PR8/34 (H1N1) virus reproduction and inhibits the synthesis of virus‐specific proteins in MDCK cells.

TL;DR: It is suggested that LRP is the functional receptor for α2‐macroglobulin‐proteinase complexes (α2MR) and in addition may have as yet unsettled functions in lipoprotein metabolism.

TL;DR: Quercetin markedly inhibited the growth of human gastric cancer cells and the IC 50 value was 32–55 μM, while DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercet in for 2 days.

TL;DR: All‐D‐magainin‐2 was synthesized to corroborate experimentally the notion that the biological function of a surface‐active peptide stems primarily from its unique amphiphilic α ‐helical structure.

TL;DR: The complete amino‐acid sequence of the bovine olfactory epithelium adenosine 3',5'cyclic monophosphate (cAMP)‐ gated channel has been determined by cloning and sequencing its cDNA, suggesting that cyclic nucleotide‐gated channels fall into a new family of genetically related proteins.

TL;DR: The complete amino acid sequence of the receptor for organic calcium channel blockers (CaCB) from rabbit lung has been deduced by cloning and sequence analysis of the cDNA.

TL;DR: Modulation of Ca2+ metabolism during cell activation may represent a common pathway for field coupling to cellular systems.

TL;DR: The structural features suggest that annexin V attaches with its convex face to membranes by specified calcium mediated interactions with at least three phospholipids, and the adjacent membrane bilayer may thus become locally disordered and permeable to allow calcium inflow through the central polar channel of the molecule.

TL;DR: sequence analysis has revealed that the human brain natriuretic peptide is a 32‐amino‐acid peptide with the sequence S‐P‐K‐M‐V‐Q‐G‐S‐ G‐C‐F‐G-R‐K-M‐D‐R‐I‐S-S‐S'G‐L-G‐C-K‐V-L‐R•R‐H, which is identical to the C‐terminal sequence

TL;DR: Five protein serine/threonine phosphatases (PP) have been identified by cloning cDNA from mammalian and Drosophila libraries and the complete amino acid sequences of PPX, PPY and PPZ and an almost complete sequence of PPV are presented.

TL;DR: The peptides discovered in this study may just be the first in a whole series of substances from arthropod species to be identified as tachykinin family peptides, and both chemical and biological similarities of vertebrate and insect tachy Kinins substantiate the evidence for a long evolutionary history of the tachyKinin peptide family.

TL;DR: Methyllycaconitine is the first low molecular weight ligand to be shown to discriminate between muscle nicotinic receptors and their α‐bungarotoxinbinding counterpart in the brain, and as such may be a useful structural probe for pursuing the structural and functional properties of the neuronal protein.

TL;DR: The kinetics of the esterification of oleic acid by ethanol catalyzed by immobilized lipase of Mucor miehei in n‐hexane as a solvent are suggested to agree with a Ping‐Pong Bi Bi mechanism.

TL;DR: Two homologous sulfur‐rich basic polypeptides form wheat endosperm, so‐called γ1‐Purothionin and γ2‐purothIONin, are described and present a high degree of homology among themselves and are the first two thionin‐like polypePTides, so-called y‐thionins, described from wheatendosperm.

TL;DR: The possibility that hyperglycemia in diabetic patients enhances ET‐1‐LI release at the local site of vascular endothelium may be involved in the developments of vascular complications and atherosclerosis.

TL;DR: Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour‐promoting phorbol esters, and appears to interact with many signalling pathways.

TL;DR: The crystal structure of porin from Rhodobacter capsulatus strain 37b4 has been solved at 3.0 Å (1 Å = 0.1 nm) resolution by multiple isomorphous replacement and solvent‐flattening.

TL;DR: A differentiation‐linked increase in calponin expression in embryonic chick gizzard is demonstrated using a monoclonal antibody specific for avian calp onin, suggested as a potentially useful index of smooth muscle differentiation.

TL;DR: It is concluded that the inhibitory effect of flufenamate, mefenamate and niflumate is dependent on the specific structure, consisting of two phenyl rings linked by an amino bridge.

TL;DR: The elucidation of the actions of Pb2+ on the NMDA receptor ion channel complex provides important insights into the clinical and toxic effects of this cation.