TL;DR: The chemistry of glycation and AGEs is introduced and the mechanisms by which they mediate their toxicity are examined and the role of A GEs in the pathogenesis of retinopathy, cataract, atherosclerosis, neuropathy, nephropathy, diabetic embryopathy and impaired wound healing are considered.
TL;DR: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and abdominal fat distribution to prevent elevations in cytokine Levels.
TL;DR: Lifestyle intervention aimed at achieving ideal body weight in men with IGT is effective and can be conducted in an outpatient clinic setting, and a linear correlation between the incidence of diabetes and the BMI values was revealed with the exception of the DaQing Study.
TL;DR: The results underscore the complexity of primary care management of T2DM and suggest that current treatment approaches are not intensive enough for a large proportion of patients especially those with longer duration of disease.
TL;DR: SES, assessed with any of three common measures, is a risk factor for diagnosed diabetes in women and among men these associations are less consistent.
TL;DR: The high prevalence of the metabolic syndrome in adult Hong Kong Chinese, particularly in the elderly, forewarns a rapidly increasing problem in Mainland China, and other Asian populations, which may have overwhelming public health ramifications.
TL;DR: Hand grip strength and key pinch power values were found to be lower in patients with T2DM than in age-matched control subjects, and physicians should be aware of this.
TL;DR: Diabetes, obesity and hypertension are extremely prevalent in the adult population of the United Arab Emirates and prompt action is required to avert a major public health crisis due to the long-term complications of diabetes in the near future.
TL;DR: A diabetes risk score involving simple non-biochemical measurements was developed and validated in a native Asian Indian population and could play an important role as the first step in the process of identifying individuals with an increased likelihood of having prevalent but undiagnosed diabetes.
TL;DR: It is suggested that MS is found in approximately one-third of the Venezuelan adult population in Zulia State, with higher prevalence in men related to the presence of dyslipidemia, and lifestyle interventions in MS subjects are needed in Venezuela to halt the burden of CV disease and diabetes.
TL;DR: It is confirmed that the absence of retinopathy and short duration of diabetes are useful clinical indications for renal biopsy in diabetic patients with overt proteinuria.
TL;DR: Improvement of carbohydrate metabolism with a consequential decrease in the formation of AGE is an important contributor to the prevention and treatment of diabetic nephropathy and atherosclerosis.
TL;DR: The prevalence of MES in Hong Kong Chinese of working age ranges from 6.1 to 13.4% depending on various diagnostic criteria and the inclusion of albuminuria and insulin resistance by the WHO has made it the most discriminative criterion in identifying at risk individuals in all age groups.
TL;DR: A linear component of trend in risk of GDM with increasing plasma TG was noted, and associations between GDM risk and plasma concentrations of other lipids were not evident.
TL;DR: Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients, and were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations.
TL;DR: The number of testing sites and the proportion needed to be insensate for the optimal assessment of foot ulcer risk with the 10 g monofilament are studied and the sensitivity and specificities are compared with other methodologies.
TL;DR: It is confirmed that Type 2 diabetes is increasing dramatically in societies in epidemiologic transition and is strongly linked to nutritional status.
TL;DR: In this paper, the levels of diabetes-specific emotional problems in diabetic individuals with high versus low levels of depression in a sample of 539 outpatients with diabetes (202 Dutch, 185 Croatian and 152 English). Subjects completed the Center for Epidemiological Studies Depression and the Problem Areas in Diabetes scales.
TL;DR: Du-zhong leaves supplement seemed to be helpful to preserve the normal histological appearance of pancreatic islets as well as to preserve insulin-positive beta-cells but it did not reverse the effect of STZ to a great extent.
TL;DR: All three drugs are safe, but that tolerability profiles vary, and each treatment provides an alternative therapy for type 2 diabetes, dependent on the particular needs of individual patients.
TL;DR: It seems probable that OCIF/OPG has a suppressive role on the increased bone resorption to prevent further loss of the skeletal bone mass in type 2 diabetic patients.
TL;DR: The PMPs levels and the expression of platelet CD62P and CD63 were measured and high correlations indicate that increased levels of PMPs may accelerate diabetic retinopathy.
TL;DR: The aim of this study was to determine ghrelin levels of atypical antipsychotic-treated patients in relationship with their body mass index (BMI) and carbohydrate metabolism, and to find the orexigen effect of elevated serum gh Relin levels can contribute to the weight-gain and high diabetes prevalence associated with atypicals antipsychotics.
TL;DR: The present study suggests that BMI and WC were useful for predicting multiple metabolic disorders in non-diabetic Mongolians and Japanese, while the use of plasma triglyceride and HDL-cholesterol levels in combination with BMI andWC may enhance the ability of predicting metabolic parameters in the Japanese.
TL;DR: The addition of a thiazolinedione to glimepiride treatment in type 2 diabetic subjects with the metabolic syndrome is associated with a slight but significant reduction of PAI-1 value, related to a similar reduction in insulinresistance.
TL;DR: It is suggested that an increase of regular physical activity equivalent to 45 min of walking 3 days/week may suffice to improve systolic and diastolic blood pressure, lipid metabolism and BMI in patients with type 2 diabetes.
TL;DR: It is shown that repaglinide produces measurable antioxidative effects at therapeutic dose and did not affect the glucose level but reduced to some extent the oxidative stress enhanced by chronic hyperglycemia.