Abstract: The performance of nanofluids is largely determined by their thermophysical properties. Optimizing these properties can significantly enhance nanofluid performance. This study introduces a hybrid strategy based on computational intelligence to determine the optimal conditions for ternary hybrid nanofluids. The goal is to minimize dynamic viscosity and maximize thermal conductivity by varying the volume fraction, temperature, and nanomaterial mixing ratio. The proposed strategy integrates machine learning, multi-objective optimization, and multi-criteria decision-making. Three machine learning techniques—GMDH-type neural network, gene expression programming, and combinatorial algorithm—are applied to model dynamic viscosity and thermal conductivity as functions of the input variables. Then, the high-performing models provide the foundation for optimization using the well-established multi-objective particle swarm optimization algorithm. Finally, the decision-making technique TOPSIS is employed to identify the most desirable points from the Pareto front, based on various design scenarios. To validate the proposed strategy, a ternary hybrid nanofluid composed of graphene oxide (GO), iron oxide (Fe₃O₄), and titanium dioxide (TiO₂) was employed as a case study. The results demonstrated that the combinatorial approach excelled in accurately modeling (R = 0.99964–0.99993). The optimization process revealed that optimal VFs span a broad range across all mixing ratios, while optimal temperatures were consistently near the maximum value (65 °C). The decision-making outcomes indicated that the mixing ratio was consistent across all design scenarios, with the volume fraction serving as the key differentiating factor.

Abstract: Network security is crucial in today's digital world, since there are multiple ongoing threats to sensitive data and vital infrastructure. The aim of this study to improve network security by combining methods for instruction detection from machine learning (ML) and deep learning (DL). Attackers have tried to breach security systems by accessing networks and obtaining sensitive information.Intrusion detection systems (IDSs) are one of the significant aspect of cybersecurity that involve the monitoring and analysis, with the intention of identifying and reporting of dangerous activities that would help to prevent the attack.Support Vector Machine (SVM), K-Nearest Neighbors (KNN), Random Forest (RF), Decision Tree (DT), Long Short-Term Memory (LSTM), and Artificial Neural Network (ANN) are the vector figures incorporated into the study through the results. These models are subjected to various test to established the best results on the identification and prevention of network violation. Based on the obtained results, it can be stated that all the tested models are capable of organizing data originating from network traffic. thus, recognizing the difference between normal and intrusive behaviors, models such as SVM, KNN, RF, and DT showed effective results. Deep learning models LSTM and ANN rapidly find long-term and complex pattern in network data. It is extremely effective when dealing with complex intrusions since it is characterised by high precision, accuracy and recall.Based on our study, SVM and Random Forest are considered promising solutions for real-world IDS applications because of their versatility and explainability. For the companies seeking IDS solutions which are reliable and at the same time more interpretable, these models can be promising. Additionally, LSTM and ANN, with their ability to catch successive conditions, are suitable for situations involving nuanced, advancing dangers.

Abstract: Studies of microbial communities vary widely in terms of analysis methods. In this growing field, the wide variety of diversity measures and lack of consistency make it harder to compare different studies. Most existing alpha diversity metrics are inherited from other disciplines and their assumptions are not always directly meaningful or true for microbiome data. Many existing microbiome studies apply one or some alpha diversity metrics with no fundamentals but also an unclear results interpretation. This work focuses on a theoretical, empirical, and comparative analysis of 19 frequently and less-frequently used microbial alpha diversity metrics grouped into 4 proposed categories, including key features of every analyzed metric with their mathematical assumptions, to provide a deeper understanding of the existing metrics and a practical implementation guide for future studies. Key metrics that should be required in microbiome analysis include richness, phylogenetic diversity, entropy, dominance of a few microbes over others, and an estimate of unobserved microbes. Collectively, these metrics contribute to a comprehensive set of analyses characterizing samples, allowing the determination of key aspects that might be otherwise obscured by partial or biased information. These guidelines enable further detailed analysis by each author according to their specific interests and clinical trials. Several practical examples are provided to illustrate how these recommendations improve the quality and depth of information obtained, facilitating better interpretation when working with microbiome data. These guidelines can be applied to both existing and future research studies, enhancing the standardization, consistency, and robustness of the analyses conducted. This approach aims to improve the capture of biological diversity, leading to better interpretations and insights.

Abstract: Accurate measurement of tryptophan (Trp) levels is crucial for clinical and research purposes, such as nutritional assessment, disorder diagnosis, condition management, and the study of the role of Trp in disease pathophysiology. Herein, the intercalation of 1-octyl-3-methylimidazolium chloride [OMIM]+Cl− ionic liquids (ILs) between the layers of Ti3C2 MXenes results in a 3D porous structure with a large active surface area and high interlayer spacing (d-spacing). Confined [OMIM]+ ions enhance the electroactive sites and Trp transfer pathways at the Ti3C2 MXene and IL interfaces and improve the electron transfer efficiency for Trp oxidation, improving Ti3C2 MXene stability via strong π‒π and electrostatic Ti3C2 MXene‒IL interactions. Under optimal conditions, the sensor demonstrated a broad detection range for Trp, ranging from 0.001 to 240 µM, with a low limit of detection of 0.06 nM (S/N = 3). Owing to its exceptional stability, selectivity, and reproducibility, the proposed IL-Ti3C2/GCE exhibited significant potential for detecting Trp in real amino acid granules and urine samples.

Abstract: This study addresses the significant issue of rapid land use and land cover (LULC) changes in Lahore District, which is critical for supporting ecological management and sustainable land-use planning. Understanding these changes is crucial for mitigating adverse environmental impacts and promoting sustainable development. The main goal is to evaluate historical LULC changes from 1994 to 2024 and forecast future trends for 2034 and 2044 utilizing the CA-Markov hybrid model combined with GIS methodologies. Landsat images from various sensors (TM, OLI) were employed for supervised classification, attaining high accuracy (> 90%). Historical LULC changes from 1994 to 2024 were analyzed, revealing significant transformations in Lahore. The build-up area expanded by 359.8 km², indicating rapid urbanization, while vegetation cover decreased by 198.7 km² and barren lands by 158.5 km². Water bodies remained relatively stable during this period. Future LULC trends were projected for 2034 and 2044 using the CA-Markov hybrid model (CA-MHM), which achieved a high prediction accuracy with a kappa coefficient of 0.92. The research indicated significant urban growth at the expense of vegetation and barren land. Future forecasts suggest ongoing urbanization, underscoring the necessity for sustainable land management techniques. This research is a significant framework for urban planners, providing insights that combine development with ecological conservation. The results highlight the necessity of incorporating predictive models into urban policy to promote sustainable development and environmental preservation in quickly changing areas such as Lahore.

Abstract: Worldwide, Cancer remains a significant health concern due to its high mortality rates. Despite numerous traditional therapies and wet-laboratory methods for treating cancer-affected cells, these approaches often face limitations, including high costs and substantial side effects. Recently the high selectivity of peptides has garnered significant attention from scientists due to their reliable targeted actions and minimal adverse effects. Furthermore, keeping the significant outcomes of the existing computational models, we propose a highly reliable and effective model namely, pACP-HybDeep for the accurate prediction of anticancer peptides. In this model, training peptides are numerically encoded using an attention-based ProtBERT-BFD encoder to extract semantic features along with CTDT-based structural information. Furthermore, a k-nearest neighbor-based binary tree growth (BTG) algorithm is employed to select an optimal feature set from the multi-perspective vector. The selected feature vector is subsequently trained using a CNN + RNN-based deep learning model. Our proposed pACP-HybDeep model demonstrated a high training accuracy of 95.33%, and an AUC of 0.97. To validate the generalization capabilities of the model, our pACP-HybDeep model achieved accuracies of 94.92%, 92.26%, and 91.16% on independent datasets Ind-S1, Ind-S2, and Ind-S3, respectively. The demonstrated efficacy, and reliability of the pACP-HybDeep model using test datasets establish it as a valuable tool for researchers in academia and pharmaceutical drug design.

Abstract: This paper introduces the Efficient Metaheuristic BitTorrent (EM-BT) algorithm, aimed at optimizing the placement and sizing of photovoltaic renewable energy sources (PVRES) and capacitor banks (CBs) in electric distribution networks. The main goal is to minimize energy losses and enhance voltage stability over 24 h, taking into account varying load profiles, solar irradiance, and temperature effects. The algorithm is rigorously tested on standard distribution networks, including the IEEE 33, IEEE 69, and ZB-ALG-Hassi Sida 157-bus systems. The results reveal that EM-BT outperforms established methods like Particle Swarm Optimization (PSO), Grey Wolf Optimizer (GWO), and Whale Optimization Algorithm (WOA), demonstrating its effectiveness in reducing energy losses and maintaining stable voltage profiles. By effectively combining PVRES and CBs, this research highlights a robust approach to enhancing both technical performance and operational reliability in distribution systems. Additionally, the consideration of temperature effects on PVRES efficiency adds depth to the study, making it a valuable contribution to the field of power system optimization.

Abstract: ChatGPT is a highly sophisticated AI language model that can revolutionize students’ learning experiences by providing much-needed assistance and information. Given the growing trend of educational institutions integrating AI technologies into their teaching and learning processes, it is crucial to understand the factors that would lead to the acceptance and use of these technologies by students. Using a technology acceptance model, this study investigated the mediating role of satisfaction in the relationship between PU, PEU, and behavioral intention to use ChatGPT for student learning. This study used a quantitative research approach, and data were gathered from 297 students using a structured questionnaire. The analysis was conducted using structural equation modelling (SEM) in AMOS Version 26. The results indicated that PU and ease PEU significantly influenced student satisfaction. PU significantly influenced behavioral intentions to use ChatGPT. However, PEU had no direct impact on students’ behavioral intention to use ChatGPT. Satisfaction had a significant influence on students’ behavioral intention to use ChatGPT. Moreover, satisfaction was confirmed as a significant partial mediator between PU and behavioral intention, as well as a full mediator of the relationship between PEU and behavioral intention. These findings underscore the need to make ChatGPT more useful in academic environments to facilitate increased engagement among students and achieve better learning outcomes. This study enhances the literature on technology acceptance in the context of education, particularly regarding the application of AI tools in learning spaces.

Abstract: The most prevalent form of malignant tumors that originate in the brain are known as gliomas. In order to diagnose, treat, and identify risk factors, it is crucial to have precise and resilient segmentation of the tumors, along with an estimation of the patients' overall survival rate. Therefore, we have introduced a deep learning approach that employs a combination of MRI scans to accurately segment brain tumors and predict survival in patients with gliomas. To ensure strong and reliable tumor segmentation, we employ 2D volumetric convolution neural network architectures that utilize a majority rule. This method helps to significantly decrease model bias and improve performance. Additionally, in order to predict survival rates, we extract radiomic features from the tumor regions that have been segmented, and then use a Deep Learning Inspired 3D replicator neural network to identify the most effective features. The model presented in this study was successful in segmenting brain tumors and predicting the outcome of enhancing tumor and real enhancing tumor. The model was evaluated using the BRATS2020 benchmarks dataset, and the obtained results are quite satisfactory and promising.

Abstract: The choice of the optimal printing setup for Fused Deposition Modeling (FDM) 3D-printing technology is challenging due to complex interactions between process parameters and mechanical properties. This especially affects engineering applications where the maximum performance is required. To address this challenge, this study explores the influence of main controllable printing parameters including layer thickness, extrusion temperature, printing speed and deposition patterns, on the mechanical properties of FDM-printed ABS specimens using the Design-of-Experiments (DoE) approach by a 34\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$3^4$$\end{document} full factorial design. Main-effects and Interaction-effects on tensile strength, elastic modulus, and strain at maximum stress are investigated via ANOVA analysis, providing interesting hints to evaluate at the design stage. Given the complexity of these effects, a deeper investigation is conducted with a quadratic regression model of the Response Surface Method and the Random Forest regressor, with the latter enhancing the predictive capability (R2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R^2$$\end{document}) on test data by more than 40% for all the mechanical properties. Eventually, a Genetic Algorithm (NSGA-II) is integrated to estimate the optimal parameter set for multiple responses. Overall results indicate that the deposition strategy is the parameter affecting the most the overall mechanical response, with “Lines” pattern providing the best balanced results in maximizing the elastic modulus and the tensile strength, respectively 1381 MPa and 33.3 MPa. Testing of a set of specimens printed with the found optimal parameters confirm the model’s prediction.

Abstract: This study examines global, regional, and national trends in melanoma and non-melanoma skin cancer (NMSC) burden from 1990 to 2021, their socioeconomic associations, and projects future trends. Data was extracted from the Global Burden of Disease (GBD) 2021 database, focusing on malignant melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Joinpoint regression, age-period-cohort modeling, and decomposition analysis were used to assess temporal trends. The Socio-Demographic Index (SDI) was applied to examine the correlation between skin cancer burden and socioeconomic development, and ARIMA models forecasted future trends. The global burden of skin cancers has shown significant growth over the study period, with the age-standardized incidence rate (ASIR) rising globally (Estimated Annual Percentage Change, EAPC = 1.94%) from 1990 to 2021. This increase was particularly pronounced for BCC and SCC, while the melanoma DALYs rate declined (EAPC = -0.67%). In 2021, the most recent year covered, the global incidence of skin cancers was 6.64 million cases, with an ASIR of 77.66 per 100,000 and a disability-adjusted life years (DALYs) burden of 2.89 million cases. Significant geographic disparities were observed, with Australasia and North America reporting the highest ASIR, while middle-SDI regions exhibited rapid increases. Skin cancer incidence is rising globally, driven by demographic changes, increased UV exposure, and improved detection. The burden of melanoma has decreased, which may be related to advances in treatment. Targeted prevention, equitable access to care, and tailored regional strategies are crucial to mitigating the growing impact of skin cancers worldwide.

Abstract: Breast cancer is one of the most aggressive types of cancer, and its early diagnosis is crucial for reducing mortality rates and ensuring timely treatment. Computer-aided diagnosis systems provide automated mammography image processing, interpretation, and grading. However, since the currently existing methods suffer from such issues as overfitting, lack of adaptability, and dependence on massive annotated datasets, the present work introduces a hybrid approach to enhance breast cancer classification accuracy. The proposed Q-BGWO-SQSVM approach utilizes an improved quantum-inspired binary Grey Wolf Optimizer and combines it with SqueezeNet and Support Vector Machines to exhibit sophisticated performance. SqueezeNet's fire modules and complex bypass mechanisms extract distinct features from mammography images. Then, these features are optimized by the Q-BGWO for determining the best SVM parameters. Since the current CAD system is more reliable, accurate, and sensitive, its application is advantageous for healthcare. The proposed Q-BGWO-SQSVM was evaluated using diverse databases: MIAS, INbreast, DDSM, and CBIS-DDSM, analyzing its performance regarding accuracy, sensitivity, specificity, precision, F1 score, and MCC. Notably, on the CBIS-DDSM dataset, the Q-BGWO-SQSVM achieved remarkable results at 99% accuracy, 98% sensitivity, and 100% specificity in 15-fold cross-validation. Finally, it can be observed that the performance of the designed Q-BGWO-SQSVM model is excellent, and its potential realization in other datasets and imaging conditions is promising. The novel Q-BGWO-SQSVM model outperforms the state-of-the-art classification methods and offers accurate and reliable early breast cancer detection, which is essential for further healthcare development.

Abstract: The increasing prevalence of network connections is driving a continuous surge in the requirement for network security and safeguarding against cyberattacks. This has triggered the need to develop and implement intrusion detection systems (IDS), one of the key components of network perimeter aimed at thwarting and alleviating the issues presented by network invaders. Over time, intrusion detection systems have been instrumental in identifying network breaches and deviations. Several researchers have recommended the implementation of machine learning approaches in IDSs to counteract the menace posed by network intruders. Nevertheless, most previously recommended IDSs exhibit a notable false alarm rate. To mitigate this challenge, exploring deep learning methodologies emerges as a viable solution, leveraging their demonstrated efficacy across various domains. Hence, this article proposes an optimized Long Short-Term Memory (LSTM) for identifying anomalies in network traffic. The presented model uses three optimization methods, i.e., Particle Swarm Optimization (PSO), JAYA, and Salp Swarm Algorithm (SSA), to optimize the hyperparameters of LSTM. In this study, NSL KDD, CICIDS, and BoT-IoT datasets are taken into consideration. To evaluate the efficacy of the proposed model, several indicators of performance like Accuracy, Precision, Recall, F-score, True Positive Rate (TPR), False Positive Rate (FPR), and Receiver Operating Characteristic curve (ROC) have been chosen. A comparative analysis of PSO-LSTMIDS, JAYA-LSTMIDS, and SSA-LSTMIDS is conducted. The simulation results demonstrate that SSA-LSTMIDS surpasses all the models examined in this study across all three datasets.

Abstract: This study focused on simulating the adsorption-based separation of Methylene Blue (MB) dye utilising Oryza sativa straw biomass (OSSB). Three distinct modelling approaches were employed: artificial neural networks (ANN), adaptive neuro-fuzzy inference systems (ANFIS), and response surface methodology (RSM). To evaluate the adsorbent's potential, assessments were conducted using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The evaluation of RSM, ANN, and ANFIS included the quantification of R2, mean squared error (MSE), root mean square error (RMSE), and mean absolute error (MAE) metrics. The regression coefficients from the process modelling demonstrated that RSM (R2 = 0.9216), ANN (R2 = 0.8864), and ANFIS (R2 = 0.9589) all accurately predicted MB adsorptive removal. However, comparative statistical analysis revealed that the ANFIS model exhibited superior accuracy in data-based predictions compared to ANN and RSM models. The ideal pH for MB adsorption utilizing OSSB was established as 7. Additionally, favourable outcomes were obtained with 60-minute contact durations, 20 mg adsorbent quantities, and temperatures of 30 °C. The pseudo 2nd -order kinetic model for MB adsorption by OSSB was confirmed. The equilibrium data exhibited a superior fit with the Langmuir isotherm model in comparison to the Freundlich model. The thermodynamic adsorption parameters, including (∆G = -9.1489 kJ/mol), enthalpy change (∆H = -1457.2 kJ/mol), and entropy change (∆S = -19.03 J mol−1 K−1) indicated that the adsorption of MB onto the OSSB surface is exothermic and spontaneous under the experimental conditions. This research effectively showcased the potential of RSM, ANN, and ANFIS in simulating dye removal using OSSB. The generated parameter data proved valuable for the design and control of the adsorption process.

Abstract: Osteoarthritis (OA) is a major global health burden, affecting millions and causing significant disability. Understanding its trends and determinants is crucial for effective management and prevention. We analyzed data from the Global Burden of Diseases (GBD) study 2021 to assess OA incidence, Years Lived with Disability (YLDs), and age-standardized rates (ASIR/ASYR) from 1990 to 2021. We explored trends and determinants across gender, region, and Socio-Demographic Index (SDI) quintiles using Joinpoint regression, Age-Period-Cohort (APC) modeling, decomposition, and inequality analyses. The global incidence of OA surged from 20.9 million in 1990 to 46.6 million cases in 2021, with an AAPC of 0.29%. Correspondingly, YLDs escalated from 8.92 million to 21.30 million, reflecting an AAPC of 0.30%. Disparities exist across SDI quintiles, with higher rates observed in high SDI countries. Women consistently experience a higher burden compared to men. Asian regions demonstrate the fastest rise in ASYR. High BMI contributes significantly to OA burden, particularly in high SDI countries. The rising burden of OA necessitates urgent attention. Interventions targeting modifiable risk factors, such as obesity, and early detection and management strategies are crucial. Addressing gender disparities and health inequalities, particularly in high SDI countries, is essential for effective OA prevention and control.