Case Study and Case Report 

Abstract: Introduction: The current case study describes the safety and prolonged therapeutic effect of an investigational drug (CPI-613) in a patient (Patient LRW) with Stage IV pancreatic neuroendocrine tumors Case presentation: Patient LRW was an 88-year old Caucasian woman who was diagnosed with pancreatic neuroendocrine tumors, and had been treated with Sandostatin followed by Enzastaurin Prior to treatment with CPI-613, she was suffering from progressive Stage IV disease, with lesions located in multiple areas including the pancreas, liver, lung, uterine, stomach, thyroid nodule, etc During the one-year treatment with CPI-613, only two incidents of mild (Grade 1) and transient adverse events (metallic taste and hyperuricemia) were observed The Progression-Free Survival was >15 months (Patient LRW still alive as of June 2011), which is consistent with the reported median Progression-Free Survival of 114 months with Everolimus treatment and 114-126 months with Sunitinib treatment Since the disease remained stable for a year during treatment with CPI-613, Patient LRW was switched to maintenance therapy with CPI-613 and is currently doing well Conclusion: In Patient LRW, who had Stage IV pancreatic neuroendocrine tumor with Disease Progression, CPI-613 therapy provided long-term Stable Disease and with only 2 minor transient incidents of adverse events during a one-year treatment This is an uncommon case where chemotherapy with an investigational drug is providing long-term stabilization of advanced metastatic disease without significant adverse events

Abstract: Rapid changes in the health system require a new trained professionals who fully understand the processes of health and organizational problems and have the knowledge and skills that enable them to manage health care facilities. Moreover, the health of its largely based on a system of solidarity and "socialism", and only partly on market principles, and more than in other sectors of the economy requires individuals who are able to bridge that gap. Achieve savings in a system that on one hand it is not profitable, on the other hand is capable to swallow a huge asset skills is that, quite simply, has to learn - just relying on common sense and intuition that no longer helps. Globalization of world markets faster and innovative technical and technological progress are almost completely changed the business environment, on whose certainty almost can not be words. Today, each order service businesses and even health services must be locally and globally competitive, because survival in the market, because the competition knows no bounds.

Abstract: Medicinal plants are major source of drugs for the treatment of various health disorders. Berberis lyceum Royal, an indigenous plant of the Northern Area of Pakistan, which has been used for its therapeutic value. A case study conducted on animal and human models shows that it has bone healing activity. Plant root is rich in the nutrients like calcium and magnesium that help to boost the recovery against bone fracture. Plants also show the antimicrobial activity in vivo.

Abstract: In journalism, case report is a very important kind of publication. It can be seen in many general medical and scientific journals. By nature, case report is a qualitative report on interesting specific situation, which can be useful and valuable for the readers. For general author, writing case report might be interesting and the way to succeed in preparation of a case report is challenging. Here, some tips for beginning writing and publishing a case report is presented. “What”, “Why” and “How” to report are the basic questions. In this editorial, these issues will be mentioned.