TL;DR: It is concluded that antibody STRO-1 binds to BM stromal elements with the capacity to transfer the hematopoietic microenvironment in vitro.

TL;DR: In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation, and the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse is isolated.

TL;DR: The immune recognition-induced lymphokines (ILs) as discussed by the authors are a class of proteins that are specifically designed for peptides derived from the eliciting antigen, bound to a groove in a class I or a class II major histocompatibility complex molecule.

TL;DR: Reduction of infarct size, preservation of ventricular function, and reduction in mortality has been obtained with SK, rt-PA, and APSAC, and thrombolytic therapy has become standard treatment for early acute myocardial infarction.

TL;DR: Three studies suggest that CD34+ marrow cells are capable of reconstituting hematopoiesis in humans, and five patients showed durable engraftment until the time of death 82 to 386 days posttransplant.

TL;DR: The data presented in this article favor clinical use of the CD34/CD33 flow cytometry assay to guide harvesting of circulating hematopoietic progenitors for autologous transplantation and contribute to better understanding of the role played by circulating hepatopoiety progenitor cell subsets in marrow recovery after myeloablative cancer therapy.

TL;DR: Results indicate that there are no interchain disulfide bonds and suggest that all the cysteines are participants in intrachain bonds, which is consistent with the molecular weight anticipated for a glycosylated monomer.

TL;DR: Clinical and laboratory findings are compatible with reported in vitro and in vivo effects of several inflammatory cytokines and indicate that studies of FHL may contribute to the understanding of cytokine effects in vivo.

TL;DR: The clinical course was progressive with a median survival of 7.5 months and the response rate increased to 58% in patients with a CD4+ CD8- phenotype, and a subgroup of patients may benefit from deoxycoformycin.

TL;DR: A large panel of monoclonal antibodies was used to characterize in detail the phenotypic changes during isolation and stimulation of human neutrophils and concluded that 7D5-as "early activation" marker--does not necessarily discriminate between primed or resting neutrophil with respect to NADPH oxidation activity.

TL;DR: It is suggested that RA should be replaced by conventional chemotherapy as soon as CR is achieved, and the sensitivity of newly emerged leukemic clones to RA was greatly reduced.

TL;DR: It is suggested that mdr1 expression contributes to chemoresistance in acute leukemia, and determination of m dr1 gene expression may be useful in designing therapy for patients with leukemia.

TL;DR: Pure recombinant human MCP-1/JE is purified and demonstrated that it is chemotactic for human monocytes with a specific activity similar to natural M CP-1 and helps to define functionally a well-known growth factor-inducible gene and a member of a new family of cytokines.

TL;DR: It is concluded that IDR/Ara-C can effectively replace standard therapy with DNR/ARA-C in adult patients less than age 60 with newly diagnosed AML.

TL;DR: It is shown that the Rh locus carried by the genome of RhD-positive individuals is composed of two different but strongly related genes of identical general organization whether they expressed the C or c and E or e antigens, and, surprisingly, even when they do not express these epitopes.

TL;DR: The potent synergistic interaction between SCF and other hematopoietic growth factors on a highly immature population of CD34+lin- precursor cells is demonstrated.

TL;DR: The hypothesis that the true impact of sickle RBC membrane defects on clinical phenotype is to add a stochastic influence, thereby modulating (and obscuring the theoretical predictability of) the fundamental predisposition to disease severity conferred by genetic determinants of Hb polymerization is put forth.

TL;DR: This is the first demonstration of a myeloid leukemia in which hypersensitivity to a specific growth factor appears to be involved in the pathogenesis of the disease.

TL;DR: It is shown that CD34+ cells and their subsets can be identified in normal PB and that the relative frequency of these Cells and their subpopulations differs in PB versus BM.

TL;DR: Results indicate that c-kit proto-oncogene is expressed in most cases of AML and is functional in terms of supporting proliferation.

TL;DR: Experiments showed that although the precursors of the hematopoietic and stromal systems share expression of CD34, they are otherwise phenotypically distinct cell types.

TL;DR: The data show that the c- kit molecule is expressed in primitive stem cells and plays an essential role in the early stages of hematopoiesis.

TL;DR: It is concluded that multiple receptor-ligand systems are involved in monocyte adherence to endothelium.