Journal• ISSN: 0303-464X
Acta Reumatologica Portuguesa
Sociedade Portuguesa de Reumatologia
About: Acta Reumatologica Portuguesa is an academic journal. The journal publishes majorly in the area(s): Medicine & Population. It has an ISSN identifier of 0303-464X. Over the lifetime, 746 publications have been published receiving 5432 citations.
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Journal Article•
TL;DR: Osteoblast have a role in regulation of bone resorption through receptor activator of nuclear factor-kappaB ligand (RANKL), that links to its receptor, RANK, on the surface of pre-osteoblast cells, inducing their differentiation and fusion.
Abstract: Bone is constantly being remodelled in a dynamic process where osteoblasts are responsible for bone formation and osteoclasts for its resorption. Osteoblasts are specialized mesenchymal cells that undergo a process of maturation where genes like core-binding factor alpha1 (Cbfa1) and osterix (Osx) play a very important role. Moreover, it was found recently that Wnt/ beta-catenin pathway plays a part on osteoblast differentiation and proliferation. In fact, mutations on some of the proteins involved in this pathway, like the low-density lipoprotein receptor related protein 5/6 (LRP5/6) lead to bone diseases. Osteoblast have also a role in regulation of bone resorption through receptor activator of nuclear factor-kappaB (RANK) ligand (RANKL), that links to its receptor, RANK, on the surface of pre-osteoblast cells, inducing their differentiation and fusion. On the other hand, osteoblasts secrete a soluble decoy receptor (osteoprotegerin, OPG) that blocks RANK/RANKL interaction by binding to RANKL and, thus, prevents osteoclast differentiation and activation. Therefore, the balance between RANKL and OPG determines the formation and activity of osteoclasts. Another factor that influences bone mass is leptin, a hormone produced by adipocytes that have a dual effect. It can act through the central nervous system and diminish osteoblasts activity, or can have an osteogenic effect by binding directly to its receptors on the surface of osteoblast cells.
276 citations
Journal Article•
TL;DR: Data suggest that RANK/RANKL/OPG system could be targeted as a new treatment strategy in bone conditions and there is accumulating evidence of the potential role of OPG and RANKL in other tissues.
Abstract: The discovery of the receptor activator of nuclear factor-kB (RANK)/RANK Ligand (RANKL)/osteoprotegerin (OPG) pathway contributed to the understanding of how bone formation and resorption were processed and regulated. RANKL and OPG are members of the tumor necrosis factor (TNF) and TNF receptor (TNFr) superfamilies, respectively, and binding to receptor activator of NF-kB (RANK) not only regulate osteoclast formation, activation and survival in normal bone modeling and remode-ling, but also in several other pathologic conditions characterized by increased bone turnover. There is accumulating evidence of the potential role of OPG and RANKL in other tissues. Looking beyond the RANK/RANKL/OPG axis, Wingless (Wnt) pathway emerged as the osteoblast differentiation way, and also as a bone mass regulator. Researchers have been discovering new molecules and cytokines interactions. Altogether, data suggest that RANK/RANKL/OPG system could be targeted as a new treatment strategy in bone conditions. FREEDOM is the more recently published clinical trial about a RANKL-specific recombinant fully human monoclonal antibody (denosumab). OPG is also a potential innovative therapeutic option to be investigated.
174 citations
Journal Article•
TL;DR: This update of a Dutch physiotherapy practice guideline on HKOA included 11 recommendations on the initial assessment, treatment and evaluation, and the implementation of the guideline in clinical practice needs further evaluation.
Abstract: BACKGROUND: An update of a Dutch physiotherapy practice guideline in Hip and Knee Osteoarthritis (HKOA) was made, based on current evidence and best practice. METHODS: A guideline steering committee, comprising 10 expert physiotherapists, selected topics concerning the guideline chapters: initial assessment, treatment and evaluation. With respect to treatment a systematic literature search was performed using various databases, and the evidence was graded (1-4). For the initial assessment and evaluation mainly review papers and textbooks were used. Based on evidence and expert opinion, recommendations were formulated. A first draft of the guideline was reviewed by 17 experts from different professional backgrounds. A second draft was field-tested by 45 physiotherapists. RESULTS: In total 11 topics were selected. For the initial assessment, three recommendations were formulated, pertaining to history taking, red flags, and formulating treatment goals. Concerning treatment, 7 recommendations were formulated; (supervised) exercise therapy, education and self management interventions, a combination of exercise and manual therapy, postoperative exercise therapy and taping of the patella were recommended. Balneotherapy and hydrotherapy in HKOA, and thermotherapy, TENS, and Continuous Passive Motion in knee OA were neither recommended nor discouraged. Massage therapy, ultrasound, electrotherapy, electromagnetic field, Low Level Laser Therapy, preoperative physiotherapy and education could not be recommended. For the evaluation of treatment goals the following measurement instruments were recommended: Lequesne index, Western Ontario and McMaster Universities osteoarthritis index, Hip disability and Osteoarthritis Outcome Score and Knee injury and Osteoarthritis Outcome Score, 6-minute walktest, Timed Up and Go test, Patient Specific Complaint list, Visual Analoge Scale for pain, Intermittent and Constant OsteoArthritis Pain Questionnaire, goniometry, Medical Research Council for strength, handheld dynamometer. CONCLUSIONS: This update of a Dutch physiotherapy practice guideline on HKOA included 11 recommendations on the initial assessment, treatment and evaluation. The implementation of the guideline in clinical practice needs further evaluation.(aut. ref.)
120 citations
Journal Article•
TL;DR: Registers are crucial to ensure correct clinical use, adequate assessment of post-marketing biological therapies' efficacy and safety, thus contributing for a better cost-benefit ratio and to improve rheumatic patients care.
Abstract: Reuma.pt is supported by unrestricted research grants from Abbott, Bristol Myers Squibb, Merck Sharp and Dohme, Pfizer, Roche and UCB Pharma.
HC received a grant from Fundacao para a Ciencia e Tecnologia (FCT), Harvard Medical School-Portugal Program, HMSP-ICS/SAU-ICT/0002/2010.
93 citations
Journal Article•
TL;DR: Obesity and diabetes are associated with disability in women with hand osteoarthritis and frequency and risk factor analyses of bone erosion of the distal interphalangeal joint in patients with rheumatoid arthritis show associations with disability.
Abstract: Frequency and risk factor analyses of bone erosion of the distal interphalangeal joint in patients 239 with rheumatoid arthritis: a cross-sectional study Ikemura S, Hagio S, Akasaki Y, Fujiwara T, Tsushima H, Nakashima Y Obesity and diabetes are associated with disability in women with hand osteoarthritis. 208 Results from the EpiReumaPt nationwide study Cruz M, Rodrigues AM, Dias S, Sepriano A, Canhão H, Gouveia N, Ramiro S, Branco JC
75 citations
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Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 7 |
| 2020 | 36 |
| 2019 | 37 |
| 2018 | 41 |
| 2017 | 45 |
| 2016 | 52 |