Institution
Yaroslavl State University
Education•Yaroslavl, Russia•
About: Yaroslavl State University is a education organization based out in Yaroslavl, Russia. It is known for research contribution in the topics: Nonlinear system & Boundary value problem. The organization has 1253 authors who have published 1967 publications receiving 10493 citations. The organization is also known as: P.G. Demidov Yaroslavl State University.
Papers published on a yearly basis
Papers
TL;DR: Signs suggest that zinc status may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity.
Abstract: In view of the emerging COVID-19 pandemic caused by SARS-CoV-2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID-19. In vitro experiments demonstrate that Zn2+ possesses antiviral activity through inhibition of SARS-CoV RNA polymerase. This effect may underlie therapeutic efficiency of chloroquine known to act as zinc ionophore. Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2. Improved antiviral immunity by zinc may also occur through up-regulation of interferon α production and increasing its antiviral activity. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions that may limit the cytokine storm in COVID-19. Improved Zn status may also reduce the risk of bacterial co-infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. Zinc status is also tightly associated with risk factors for severe COVID-19 including ageing, immune deficiency, obesity, diabetes, and atherosclerosis, since these are known risk groups for zinc deficiency. Therefore, Zn may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity. However, further clinical and experimental studies are required.
464 citations
TL;DR: The system is able to visualize various states of the breast and it may be possible to apply it to breast cancer detection, and results of clinical evaluation of the system are presented.
Abstract: A medical device which allows imaging of the distribution of conductivity in 3D in regions below the skin surface has been developed and tested Its purpose is to enable early detection and preliminary diagnosis of breast tumours Design of the measuring system and software are described Results of clinical evaluation of the system are presented EIT images of healthy and cancerous breasts are presented and discussed The system is able to visualize various states of the breast and it may be possible to apply it to breast cancer detection
270 citations
Russian Academy of Sciences1, Yaroslavl State University2, I.M. Sechenov First Moscow State Medical University3, Albert Einstein College of Medicine4, Universidade Federal de Santa Maria5, University of Agricultural Sciences, Dharwad6, Razi Vaccine and Serum Research Institute7, Innlandet Hospital Trust8
TL;DR: The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol; -SH) groups of low- and high-molecular-weight biological ligands with mercury (Hg) with special emphasis on pathways of Hg toxicity.
247 citations
TL;DR: This article reviewed the available literature on cross-observer agreement on traits of the Five-Factor Model, and provided new data from Russia and the Czech Republic Russian and Czech versions of the Revised NEO Personality Inventory showed adequate internal consistency and replicated the American factor structure and gender differences.
241 citations
Yaroslavl State University1, I.M. Sechenov First Moscow State Medical University2, Peoples' Friendship University of Russia3, Assiut University4, Razi Vaccine and Serum Research Institute5, University of Veterinary and Pharmaceutical Sciences Brno6, Ljubljana University Medical Centre7, University of Concepción8, Jazan University9, Lodz University of Technology10, University of Łódź11, University of Verona12
TL;DR: Early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage.
Abstract: According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors. The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity. Several studies have suggested that the redox imbalance and oxidative stress are integral parts of ASD pathophysiology. As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage. In this review, many aspects of the role of oxidative stress in ASD are discussed, taking into account that the process of oxidative stress may be a target for therapeutic interventions.
240 citations
Authors
Showing all 1310 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Herbert Edelsbrunner | 84 | 377 | 33877 |
| Jan Aaseth | 45 | 230 | 6286 |
| Alexander V. Mikhailov | 34 | 113 | 4844 |
| Aristides M. Tsatsakis | 32 | 148 | 3491 |
| Vladimir Sokolov | 31 | 280 | 5242 |
| A. G. Mayorov | 29 | 204 | 4387 |
| Vitaly B. Svetovoy | 28 | 127 | 2174 |
| Anatoly L. Buchachenko | 27 | 163 | 2694 |
| Ilya D. Shkredov | 26 | 178 | 1982 |
| Alexey A. Tinkov | 26 | 181 | 2527 |
| Anatoly V. Skalny | 24 | 147 | 2079 |
| Margarita G. Skalnaya | 21 | 92 | 1477 |
| Valery V. Kozlov | 20 | 217 | 3758 |
| Oleg R. Musin | 19 | 102 | 1166 |
| Alexander M. Skundin | 19 | 200 | 1737 |
Related Institutes (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 1 |
| 2025 | 34 |
| 2024 | 50 |
| 2023 | 94 |
| 2022 | 58 |
| 2021 | 138 |