Institution
Musashino University
Education•Tokyo, Japan•
About: Musashino University is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Chemistry & Medicine. The organization has 621 authors who have published 1048 publications receiving 16622 citations. The organization is also known as: Musashino Daigaku.
Topics: Chemistry, Medicine, Biology, Derivatization, Population
Papers published on a yearly basis
Papers
University of Düsseldorf1, Goethe University Frankfurt2, Vrije Universiteit Brussel3, University of Freiburg4, Leipzig University5, Dow Chemical Company6, University of Tübingen7, Durham University8, University of Turin9, Seoul National University10, University of Jena11, Charité12, University of Valencia13, Heidelberg University14, University of Paris15, French Institute for Research in Computer Science and Automation16, University of Liverpool17, University of Groningen18, Lund University19, University of Manchester20, South Valley University21, University Hospital Regensburg22, Merck KGaA23, Musashino University24, University of Kansas25, Ludwig Maximilian University of Munich26, Fresenius Medical Care27, University of Regensburg28, Merck & Co.29
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Abstract: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4α), resulting in up- and downregulation of hundreds of genes. An understanding of these changes is crucial for a correct interpretation of in vitro data. The possibilities and limitations of the most useful liver in vitro systems are summarized, including three-dimensional culture techniques, co-cultures with non-parenchymal cells, hepatospheres, precision cut liver slices and the isolated perfused liver. Also discussed is how closely hepatoma, stem cell and iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, a summary is given of the state of the art of liver in vitro and mathematical modeling systems that are currently used in the pharmaceutical industry with an emphasis on drug metabolism, prediction of clearance, drug interaction, transporter studies and hepatotoxicity. One key message is that despite our enthusiasm for in vitro systems, we must never lose sight of the in vivo situation. Although hepatocytes have been isolated for decades, the hunt for relevant alternative systems has only just begun.
1,249 citations
Columbia University1, University of California, San Diego2, University of Memphis3, University of Pittsburgh4, Harvard University5, American Foundation for Suicide Prevention6, Musashino University7, Wayne State University8, Hebrew University of Jerusalem9, University of California, Los Angeles10, University of Manitoba11, Pace University12
TL;DR: Modifications in the bereavement V code and refinement of bereavement exclusions in major depression and other disorders are discussed.
Abstract: Bereavement is a severe stressor that typically incites painful and debilitating symptoms of acute grief that commonly progresses to restoration of a satisfactory, if changed, life. Normally, grief does not need clinical intervention. However, sometimes acute grief can gain a foothold and become a chronic debilitating condition called complicated grief. Moreover, the stress caused by bereavement, like other stressors, can increase the likelihood of onset or worsening of other physical or mental disorders. Hence, some bereaved people need to be diagnosed and treated. A clinician evaluating a bereaved person is at risk for both over-and under-diagnosis, either pathologizing a normal condition or neglecting to treat an impairing disorder. The authors of DSM IV focused primarily on the problem of over-diagnosis, and omitted complicated grief because of insufficient evidence. We revisit bereavement considerations in light of new research findings. This article focuses primarily on a discussion of possible inclusion of a new diagnosis and dimensional assessment of complicated grief. We also discuss modifications in the bereavement V code and refinement of bereavement exclusions in major depression and other disorders.
1,003 citations
TL;DR: The effects of sex hormones on the RAAS can explain at least some of the gender differences in cardiovascular and kidney diseases.
Abstract: Premenopausal women are protected to some extent from cardiovascular and kidney diseases. Because this protection weakens after menopause, sex hormones are believed to play an important role in the pathogenesis of cardiovascular and kidney diseases. The cardiovascular system and the kidneys are regulated by the renin-angiotensin-aldosterone system (RAAS), which in turn, appears to be regulated by sex hormones. In general, oestrogen increases angiotensinogen levels and decreases renin levels, angiotensin-converting enzyme (ACE) activity, AT(1) receptor density, and aldosterone production. Oestrogen also activates counterparts of the RAAS such as natriuretic peptides, AT(2) receptor density, and angiotensinogen (1-7). Progesterone competes with aldosterone for mineralocorticoid receptor. Less is known about androgens, but testosterone seems to increase renin levels and ACE activity. These effects of sex hormones on the RAAS can explain at least some of the gender differences in cardiovascular and kidney diseases.
263 citations
TL;DR: Experimental results suggest that catalysis involves both carbon radical and carbocation intermediates, and Mechanistic insight into this novel catalytic system is also discussed.
Abstract: A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alcoholic solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alcohol in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Experimental results suggest that catalysis involves both carbon radical and carbocation intermediates.
210 citations
TL;DR: Interestingly, several studies using in vivo and in vitro systems suggest that glucocorticoids interact with BDNF to ultimately affect CNS function, which is putatively involved in the onset of depression when levels are abnormally high.
183 citations
Authors
Showing all 626 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Toshiaki Katada | 61 | 213 | 11663 |
| Yoshio Umezawa | 57 | 301 | 10573 |
| Kazuhiro Imai | 56 | 301 | 10686 |
| Yutaka Ebizuka | 53 | 234 | 8578 |
| Satoshi Ishii | 49 | 109 | 8784 |
| Kozo Ochi | 49 | 163 | 7359 |
| Koichiro Kawashima | 47 | 162 | 6064 |
| Kazuho Abe | 46 | 142 | 7323 |
| Junkichi Satsuma | 44 | 156 | 8916 |
| Makoto Otsuka | 44 | 282 | 6255 |
| Takemi Enomoto | 42 | 135 | 5524 |
| Takami Oka | 40 | 110 | 4622 |
| Masayasu Mimura | 39 | 174 | 5012 |
| Mamoru Senna | 36 | 309 | 5580 |
| Yukinobu Ikeya | 35 | 101 | 2785 |
Related Institutes (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 16 |
| 2024 | 14 |
| 2023 | 24 |
| 2022 | 5 |
| 2021 | 86 |
| 2020 | 80 |