Abstract: We estimate changes in forest cover (deforestation and forest regrowth) in the tropics for the two last decades (1990–2000 and 2000–2010) based on a sample of 4000 units of 10 ×10 km size. Forest cover is interpreted from satellite imagery at 30 × 30 m resolution. Forest cover changes are then combined with pan-tropical biomass maps to estimate carbon losses. We show that there was a gross loss of tropical forests of 8.0 million ha yr−1 in the 1990s and 7.6 million ha yr−1 in the 2000s (0.49% annual rate), with no statistically significant difference. Humid forests account for 64% of the total forest cover in 2010 and 54% of the net forest loss during second study decade. Losses of forest cover and Other Wooded Land (OWL) cover result in estimates of carbon losses which are similar for 1990s and 2000s at 887 MtC yr−1 (range: 646–1238) and 880 MtC yr−1 (range: 602–1237) respectively, with humid regions contributing two-thirds. The estimates of forest area changes have small statistical standard errors due to large sample size. We also reduce uncertainties of previous estimates of carbon losses and removals. Our estimates of forest area change are significantly lower as compared to national survey data. We reconcile recent low estimates of carbon emissions from tropical deforestation for early 2000s and show that carbon loss rates did not change between the two last decades. Carbon losses from deforestation represent circa 10% of Carbon emissions from fossil fuel combustion and cement production during the last decade (2000–2010). Our estimates of annual removals of carbon from forest regrowth at 115 MtC yr−1 (range: 61–168) and 97 MtC yr−1 (53–141) for the 1990s and 2000s respectively are five to fifteen times lower than earlier published estimates.

Abstract: . The study assesses the extent and trends of forest cover in Southeast Asia for the periods 1990–2000 and 2000–2010 and provides an overview on the main causes of forest cover change. A systematic sample of 418 sites (10 km × 10 km size) located at the one-degree geographical confluence points and covered with satellite imagery of 30 m resolution is used for the assessment. Techniques of image segmentation and automated classification are combined with visual satellite image interpretation and quality control, involving forestry experts from Southeast Asian countries. The accuracy of our results is assessed through an independent consistency assessment, performed from a subsample of 1572 mapping units and resulting in an overall agreement of >85% for the general differentiation of forest cover versus non-forest cover. The total forest cover of Southeast Asia is estimated at 268 Mha in 1990, dropping to 236 Mha in 2010, with annual change rates of 1.75 Mha (∼0.67%) and 1.45 Mha (∼0.59%) for the periods 1990–2000 and 2000–2010, respectively. The vast majority of forest cover loss (∼2 / 3 for 2000–2010) occurred in insular Southeast Asia. Complementing our quantitative results by indicative information on patterns and on processes of forest change, obtained from the screening of satellite imagery and through expert consultation, respectively, confirms the conversion of forest to cash crops plantations (including oil palm) as the main cause of forest loss in Southeast Asia. Logging and the replacement of natural forests by forest plantations are two further important change processes in the region.

Abstract: Nitrogen (N) accumulation rates in peatland ecosystems indicate significant biological atmospheric N2 fixation associated with Sphagnum mosses. Here, we show that the linkage between methanotrophic carbon cycling and N2 fixation may constitute an important mechanism in the rapid accumulation of N during the primary succession of peatlands. In our experimental stable isotope enrichment study, previously overlooked methane-induced N2 fixation explained more than one-third of the new N input in the younger peatland stages, where the highest N2 fixation rates and highest methane oxidation activities co-occurred in the water-submerged moss vegetation.

Abstract: Ectomycorrhizal fungi are major ecological players in temperate forests, but they are rarely used in measures of forest condition because large-scale, high-resolution, standardized and replicated belowground data are scarce. We carried out an analysis of ectomycorrhizas at 22 intensively monitored long-term oak plots, across nine European countries, covering complex natural and anthropogenic environmental gradients. We found that at large scales, mycorrhizal richness and evenness declined with decreasing soil pH and root density, and with increasing atmospheric nitrogen deposition. Shifts in mycorrhizas with different functional traits were detected; mycorrhizas with structures specialized for long-distance transport related differently to most environmental variables than those without. The dominant oak-specialist Lactarius quietus, with limited soil exploration abilities, responds positively to increasing nitrogen inputs and decreasing pH. In contrast, Tricholoma, Cortinarius and Piloderma species, with medium-distance soil exploration abilities, show a consistently negative response. We also determined nitrogen critical loads for moderate (9.5-13.5 kg N/ha/year) and drastic (17 kg N/ha/year) changes in belowground mycorrhizal root communities in temperate oak forests. Overall, we generated the first baseline data for ectomycorrhizal fungi in the oak forests sampled, identified nitrogen pollution as one of their major drivers at large scales and revealed fungi that individually and/or in combination with others can be used as belowground indicators of environmental characteristics.

Abstract: Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in development for chronic obstructive pulmonary disease (COPD). The efficacy and safety of aclidinium/formoterol versus monotherapy and placebo in patients with COPD was assessed. In this 24-week double-blind, parallel-group, active- and placebo-controlled, multicentre Phase III study, patients (≥40 years, post-bronchodilator forced expiratory volume in 1 second [FEV1]/forced vital capacity <70% and FEV1 ≥30% but <80% predicted normal) were randomised 2:2:2:2:1 to aclidinium/formoterol 400/12 μg (n = 385) or 400/6 μg (n = 381), aclidinium 400 μg (n = 385), formoterol 12 μg (n = 384) or placebo (n = 194) BID via Genuair®/Pressair®a. At Week 24, aclidinium/formoterol 400/12 μg and 400/6 μg lead to significant improvements from baseline in 1-hour post-dose FEV1 versus aclidinium (125 mL [95% CI: 90, 160; p < 0 · 001] and 69 mL [95% CI: 34, 105; p < 0.001], respectively) and trough FEV1 versus formoterol (85 mL [95% CI: 51, 119; p < 0.001] and 53 mL [95% CI: 19, 87; p < 0.01], respectively; co-primary endpoints). Additionally, aclidinium/formoterol 400/12 μg and 400/6 μg provided significant improvements in Transition Dyspnoea Index (TDI) focal score versus placebo (1.29 units [95% CI: 0.73, 1.86; p < 0.001] and 1.16 units [95% CI: 0.59, 1.73; p < 0.001], respectively; secondary endpoint). All treatments were well tolerated, with safety profiles of the FDCs similar to those of placebo and monotherapy. Both aclidinium/formoterol BID doses significantly improved bronchodilation versus monotherapy, and dyspnoea versus placebo, with no increase in safety risk. Aclidinium/formoterol may be an effective treatment for patients with COPD. ClinicalTrials.gov: NCT01462942 .

Abstract: This research gives the results of a proximate analysis (moisture, ash, crude protein, fat, total carbohydrates, and total energy); a bioactive compounds analysis (γ-aminobutyric acid [GABA], ergothioneine, lovastatin, and cordycepin); fatty acid and amino acid analysis; and an analysis of macro- and microelement content of fruit bodies and mycelia of 15 higher Basidiomycetes medicinal mushroom strains belonging to 12 species. The results obtained demonstrate that almost all investigated mushrooms were found to be good sources of proteins and carbohydrates, with content varying in the ranges of 8.6-42.5% and 42.9-83.6%, respectively. Different species exhibited distinct free amino acid profiles. The total amino acid content was highest in Ophiocordyceps sinensis (MB) (23.84 mg/g) and Cordyceps militaris (FB) (23.69 mg/g). The quantification of the identified fatty acids indicated that, in general, palmitic acid, oleic acid, stearic acid, and linoleic acid were the major fatty acids. The micro- and macroelement compositions were studied, and the highest results were (as milligrams per kilogram) 224-7307 for calcium, 1668-38564 for potassium, 1091-11676 for phosphorus, and 5-97 for zinc. Bioactive components were lovastatin, GABA, and ergothioneine, which are commonly found in most mushrooms. C. militaris (FB), Pleurotus ostreatus (FB), and Coprinus comatus (FB) were most abundant and contained a high amount of GABA (756.30 μg/g, 1304.99 μg/g, 1092.45 μg/g, respectively) and ergothioneine (409.88 μg/g, 2443.53 μg/g, 764.35 μg/g, respectively). The highest lovastatin content was observed in Hericium erinaceus (FB) (14.38 μg/g) and Ganoderma lucidum (FB) (11.54 μg/g). In contrast to C. militaris (FB), cordycepin was not detected in O. sinensis (MB). The fruit body biomass of C. militaris cordycepin content reached 1.743 mg/g dry weight. The nutritional values of the mushroom species studied here could potentially be used in well-balanced diets and as sources of bioactive compounds.

Abstract: Aim of study : We aim at (i) developing a reference definition of mixed forests in order to harmonize comparative research in mixed forests and (ii) review the research perspectives in mixed forests. Area of study : The definition is developed in Europe but can be tested worldwide. Material and Methods : Review of existent definitions of mixed forests based and literature review encompassing dynamics, management and economic valuation of mixed forests. Main results : A mixed forest is defined as a forest unit, excluding linear formations, where at least two tree species coexist at any developmental stage, sharing common resources (light, water, and/or soil nutrients). The presence of each of the component species is normally quantified as a proportion of the number of stems or of basal area, although volume, biomass or canopy cover as well as proportions by occupied stand area may be used for specific objectives. A variety of structures and patterns of mixtures can occur, and the interactions between the component species and their relative proportions may change over time. The research perspectives identified are (i) species interactions and responses to hazards, (ii) the concept of maximum density in mixed forests, (iii) conversion of monocultures to mixed-species forest and (iv) economic valuation of ecosystem services provided by mixed forests. Research highlights : The definition is considered a high-level one which encompasses previous attempts to define mixed forests. Current fields of research indicate that gradient studies, experimental design approaches, and model simulations are key topics providing new research opportunities. Keywords: COST Action; EuMIXFOR; mixed-species forests; admixtures of species.

Abstract: Background Combining two long-acting bronchodilators with complementary mechanisms of action may provide treatment benefits to patients with chronic obstructive pulmonary disease (COPD) that are greater than those derived from either treatment alone. The efficacy and safety of a fixed-dose combination (FDC) of aclidinium bromide, a long-acting muscarinic antagonist, and formoterol fumarate, a long-acting β2-agonist, in patients with moderate to severe COPD are presented.

Abstract: Elevational trends in the ecology of macroorganisms have been studied extensively; by contrast very little is known of such trends in microbial diversity. Previous studies on soil bacteria have found either a diversity decline, a ‘peak’ in mid altitudes, or no trend with increasing elevation. Here we studied bacterial diversity and community composition in relation to elevation on Mt. Halla, Jeju Island, South Korea, a massive shield volcano. Samples were taken along two transects, from 100 m.a.s.l. to the summit at 1950 m.a.s.l., at elevational intervals of 200 m. PCR-amplified soil DNA for the bacterial 16S rRNA gene targeting V1 to V3 region was 454-pyrosequenced, and taxonomically classified against EzTaxon-e database. Elevation was the best predictor of variation in bacterial community composition along the two transects, even when considering other soil parameters. Elevation was itself highly correlated with mean annual temperature (MAT) and mean annual precipitation (MAP), suggesting that soil bacterial community composition on Mt. Halla is more strongly affected by climate than by geochemical or soil textural factors. The two transects showed certain consistent differences in bacterial phyla composition, with one transect having significantly higher abundance of Planctomycetes and Gemmatimonadetes than the other. Certain other phyla (e.g. Acidobacteria) also showed striking trends in abundance with elevation, but the trends differed between the two transects. Bacterial diversity and richness were also most strongly correlated with elevation, MAT and MAP, although soil pH explained a part of the variation. Moreover, vegetation cover type, irrespective of elevation, had an effect on soil bacterial diversity and richness. We found a ‘dip’ in diversity at lower mid elevations (700–1300 m) in both transects; a trend which has not been found before. Our results, when compared with other studies, emphasize that no simple rule can be applied to mountain systems in general, but that climate itself is a major influence on community composition.

Abstract: Since the late nineteenth century when high-cost equipment was introduced into forestry there has been a need to calculate the cost of this equipment in more detail with respect to, for example, cost of ownership, cost per hour of production, and cost per production unit. Machine cost calculations have been made using various standard economic methods, where costs have been subdivided into capital costs and operational costs. Because of differences between methods and between national regulations, mainly regarding tax rules and subsidies, international comparisons of machine costs are difficult. To address this, one of the goals of the European Cooperation in Science and Technology (COST) Action FP0902 was to establish a simple format for transparent cost calculations for machines in the forest biomass procurement chain. A working group constructed a Microsoft Excel–based spreadsheet model which is easy to understand and use. Input parameters are easy to obtain or possible to estimate by provided rules of...

Abstract: Understanding the spatial distribution of the quantity and economic value of Non-Timber Forest Product (NTFP) collection gives insight into the benefits that local communities obtain from forests, and can inform decisions about the selection of forested areas that are eligible for conservation and enforcement of regulations. In this paper we estimate transferable household production functions of NTFP extraction in the Eastern Arc Mountains (EAM) in Tanzania, based on information from seven multi-site datasets related to the behaviour of over 2000 households. The study shows that the total benefit flow of charcoal, firewood, poles and thatch from the EAM to the local population has an estimated value of USD 42 million per year, and provides an important source of additional income for local communities, especially the poorest, who mainly depend on subsistence agriculture. The resulting map of economic values shows that benefits vary highly across space with population density, infrastructure and resource availability. We argue that if further restrictions on forest access to promote conservation are considered, this will require additional policies to prevent a consequent increase in poverty, and an enforced trade-off between conservation and energy supply to rural and urban households.

Abstract: Abstract The paper presents information on the projected drought exposure of Central Europe, describes the anticipated dynamics of the regional forests, and identifies measures facilitating the adaptation of forests to climate change-induced drought risk. On the basis of an ensemble of climate change scenarios we expect substantial drying in southern Slovakia and Hungary, while such trends were found to be less pronounced for the Czech Republic and Austria. In response to these climate trajectories, a change in species composition towards a higher share of drought tolerant species as well as the use of drought resistant provenances are identified as paramount actions in forest adaptation in the region. Adaptation to aggravating climate change may need to use artificial regeneration to enrich local gene pools and increase the drought tolerance of stands. Increasing risks from pests, pathogens and other disturbances are expected as a result of more frequent and severe droughts, underlining the need to put a stronger focus on risk management principles rather than on indicators of productivity in silviculture and forest planning. A consolidation of disturbance monitoring systems and a broader use of pest dynamics and hazard rating models are paramount tools to facilitate this adaptation process in forest management. The effectiveness of all the suggested measures needs to be controlled by efficient forest monitoring systems, the consolidation of which seems to be a timely task. Systematic and long-term implementation of the presented measures should increase forest stability and resilience, and further secure the sustainable provision of ecosystem services under climate change. Abstrakt V článku sú prezentované informácie o očakávanom vývoji sucha v oblasti strednej Európy, je opísaná možná dynamika lesov v podmienkach zmeny klímy, a je vypracovaný systém opatrení umožňujúcich adaptáciu lesov na zmenu klímy. Na základe kolekcie scenárov zmeny klímy bol identifikovaný výrazný nárast intenzity sucha v oblastiach južného Slovenska a Maďarska, zatiaľ čo v oblasti Českej republiky a Rakúska bola zmena relatívne nevýrazná. S ohľadom na tento vývoj predstavuje úprava drevinového zloženia smerom k vyššiemu zastúpeniu sucho tolerujúcich drevín a širšiemu využívaniu proveniencií rezistentných voči suchu jedno zo základných adaptačných opatrení. V prípade výrazných zmien klímy narastá význam umelej obnovy, ktorá predstavuje nástroj na zlepšovanie druhovej a genetickej diverzity porastov a zvyšovanie ich tolerancie voči suchu. Narastajúci vplyv škodcov súvisiaci s rastúcim vplyvom sucha a ďalších abiotických činiteľov naznačuje potrebu orientovať pestovanie a hospodársku úpravu lesa viac na manažment rizík ako na maximalizáciu produkcie. Konsolidácia systémov monitoringu škodlivých činiteľov a širšie využívanie modelov dynamiky škodcov a hodnotenia rizík patria medzi ďalšie dôležité opatrenia podporujúce adaptáciu lesov na zmenu klímy. Všetky uvedené opatrenia musia byť podporené informáciami získanými na základe dlhodobého monitoringu lesa, ktorý však vyžaduje urýchlenú konsolidáciu. Systematická a dlhodobá realizácia prezentovaných opatrení podporí stabilitu a rezilienciu lesov a vytvorí predpoklady pre udržateľné poskytovanie ekosystémových služieb a funkcií v podmienkach zmeny klímy.

Abstract: The rapidly approaching smart/wearable energy era necessitates advanced rechargeable power sources with reliable electrochemical properties and versatile form factors. Here, as a unique and promising energy storage system to address this issue, we demonstrate a new class of heterolayered, one-dimensional (1D) nanobuilding block mat (h-nanomat) battery based on unitized separator/electrode assembly (SEA) architecture. The unitized SEAs consist of wood cellulose nanofibril (CNF) separator membranes and metallic current collector-/polymeric binder-free electrodes comprising solely single-walled carbon nanotube (SWNT)-netted electrode active materials (LiFePO4 (cathode) and Li4Ti5O12 (anode) powders are chosen as model systems to explore the proof of concept for h-nanomat batteries). The nanoporous CNF separator plays a critical role in securing the tightly interlocked electrode-separator interface. The SWNTs in the SEAs exhibit multifunctional roles as electron conductive additives, binders, current collectors and also non-Faradaic active materials. This structural/physicochemical uniqueness of the SEAs allows significant improvements in the mass loading of electrode active materials, electron transport pathways, electrolyte accessibility and misalignment-proof of separator/electrode interface. As a result, the h-nanomat batteries, which are easily fabricated by stacking anode SEA and cathode SEA, provide unprecedented advances in the electrochemical performance, shape flexibility and safety tolerance far beyond those achievable with conventional battery technologies. We anticipate that the h-nanomat batteries will open 1D nanobuilding block-driven new architectural design/opportunity for development of next-generation energy storage systems.

Abstract: Summary This review comprises both well-known and recently described Phytophthora species and concentrates on Phytophthora–woody plant interactions. First, comprehensive data on infection strategies are presented which were the basis for three models that explain invasion and spread of Phytophthora pathogens in different woody host plants. The first model describes infection of roots, the second concentrates on invasion of the trunk, and the last one summarizes infection and invasion of host plants via leaves. On the basis of morphological, physiological, biochemical and molecular data, scenarios are suggested which explain the sequences of reactions that occur in susceptible and tolerant plants following infections of roots or of stem bark. Particular emphasis is paid to the significance of Phytophthora elicitins for such host–pathogen interactions. The overall goal is to shed light on the sequences of pathogenesis to better understand how Phytophthora pathogens harm their host plants.

Abstract: Negative binomial model has been increasingly used to model the count data in recent clinical trials. It is frequently chosen over Poisson model in cases of overdispersed count data that are commonly seen in clinical trials. One of the challenges of applying negative binomial model in clinical trial design is the sample size estimation. In practice, simulation methods have been frequently used for sample size estimation. In this paper, an explicit formula is developed to calculate sample size based on the negative binomial model. Depending on different approaches to estimate the variance under null hypothesis, three variations of the sample size formula are proposed and discussed. Important characteristics of the formula include its accuracy and its ability to explicitly incorporate dispersion parameter and exposure time. The performance of the formula with each variation is assessed using simulations.

Abstract: Tribulus terrestris fruits are well known for their usage in pharmaceutical preparations and food supplements. The methanol extract of T. terrestris fruits showed potent inhibition against the papain-like protease (PLpro), an essential proteolylic enzyme for protection to pathogenic virus and bacteria. Subsequent bioactivity-guided fractionation of this extract led to six cinnamic amides (1-6) and ferulic acid (7). Compound 6 emerged as new compound possessing the very rare carbinolamide motif. These compounds (1-7) were evaluated for severe acute respiratory syndrome coronavirus (SARS-CoV) PLpro inhibitory activity to identify their potencies and kinetic behavior. Compounds (1-6) displayed significant inhibitory activity with IC50 values in the range 15.8-70.1 µM. The new cinnamic amide 6 was found to be most potent inhibitor with an IC50 of 15.8 µM. In kinetic studies, all inhibitors exhibited mixed type inhibition. Furthermore, the most active PLpro inhibitors (1-6) were proven to be present in the native fruits in high quantities by HPLC chromatogram and liquid chromatography with diode array detection and electrospray ionization mass spectrometry (LC-DAD-ESI/MS).

Abstract: Background Glucocorticoid functions are markedly impaired in patients with chronic obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N-oxide (RNO) is the active metabolite of roflumilast approved as a treatment to reduce the risk of exacerbations in patients with severe COPD. Objective We sought to characterize the differential effects of RNO versus corticosteroids and their potential additive/synergistic effect in neutrophils from patients with COPD, thus providing scientific rationale for the combination of roflumilast with corticosteroids in the clinic. Methods Peripheral blood neutrophils were isolated from patients with COPD (n = 32), smokers (n = 7), and healthy nonsmokers (n = 25). Levels of IL-8, matrix metallopeptidase 9 (MMP-9), and biomarkers of glucocorticoid resistance were determined by using ELISA and RT-PCR. Neutrophils were incubated with dexamethasone (0.1 nmol/L to 1 μmol/L), RNO (0.1 nmol/L to 1 μmol/L), or the combination of 1 nmol/L RNO plus 10 nmol/L DEX and stimulated with LPS (1 μg/mL) or cigarette smoke extract 5%; levels of IL-8, MMP-9, and other biomarkers were measured at the end of the incubation period. Results Peripheral neutrophils from patients with COPD showed a primed phenotype with an increased basal release of IL-8 and MMP-9 and expressed a corticosteroid resistance molecular profile characterized by an increase in phosphoinositide 3-kinase δ, macrophage migration inhibitory factor, and glucocorticoid receptor β expression and a decrease in HDAC activity and mitogen-activated protein kinase phosphatase 1 expression. RNO demonstrated robust anti-inflammatory effects on neutrophils from patients with COPD, reversing their resistance to corticosteroids. The combination of RNO and dexamethasone showed additive/synergistic effects, which were consistent with the reversal of corticosteroid-resistant molecular markers by RNO. Conclusion RNO reverses corticosteroid resistance and shows strong anti-inflammatory effects alone or in combination with corticosteroids on neutrophils from patients with COPD.

Abstract: A B S T R A C T Using recent land cover maps, we used matching techniques to analyze forest cover and assess effectiveness in avoiding deforestation in three main land tenure regimes in Panama, namely protected areas, indigenous territories and non-protected areas. We found that the tenure status of protected areas and indigenous territories (including comarcas and claimed lands) explains a higher rate of success in avoided deforestation than other land tenure categories, when controlling for covariate variables such us distance to roads, distance to towns, slope, and elevation. In 2008 protected areas and indigenous territories had the highest percentage of forest cover and together they hosted 77% of Panama’s total mature forest area. Our study shows the promises of matching techniques as a potential tool for demonstrating and quantifying conservation efforts. We therefore propose that matching could be integrated to methodological approaches allowing compensating forests’ protectors. Because conserving forest carbon stocks in forested areas of developing countries is an essential component of REDD+ and its future success, the discussion of our results is relevant to countries or jurisdictions with high forest cover and low deforestation rates.

Abstract: Much of the world's tropical forests have been affected by anthropogenic disturbance. These forests are important biodiversity reservoirs whose diversity, structure and function must be characterized across the successional sequence. We examined changes in structure and diversity along a successional gradient in the lowlands of New Guinea. To do this, we measured and identified all stems =5 cm diameter in 19 0.25 ha plots ranging in age from 3 to >50 yr since disturbance. We also measured plant functional traits related to establishment, performance, and competitive ability. In addition, we examined change in forest structure, composition, species diversity, and functional diversity through succession. By using rarefaction to estimate functional diversity, we compared changes in functional diversity while controlling for associated differences in stem and species density. Basal area and species density increased with stand age while stem density was highest in intermediate secondary forests. Species composition differed strongly between mature and secondary forests. As forests increased in basal area, community-weighted mean wood density and foliar carbon increased, whereas specific leaf area and proportion of stems with exudate decreased. Foliar nitrogen peaked in medium-aged forests. Functional diversity was highest in mature forests, even after accounting for differences in stem and species diversity. Our study represents one of the first attempts to document successional changes in New Guinea's lowland forest. We found robust evidence that as succession proceeds, communities occupy a greater range of functional trait space even after controlling for stem and species density. High functional diversity is important for ecological resiliency in the face of global change.

Abstract: Species adapted to cold-climatic mountain environments are expected to face a high risk of range contractions, if not local extinctions under climate change. Yet, the populations of many endothermic species may not be primarily affected by physiological constraints, but indirectly by climate-induced changes of habitat characteristics. In mountain forests, where vertebrate species largely depend on vegetation composition and structure, deteriorating habitat suitability may thus be mitigated or even compensated by habitat management aiming at compositional and structural enhancement. We tested this possibility using four cold-adapted bird species with complementary habitat requirements as model organisms. Based on species data and environmental information collected in 300 1-km2 grid cells distributed across four mountain ranges in central Europe, we investigated (1) how species’ occurrence is explained by climate, landscape, and vegetation, (2) to what extent climate change and climate-induced vegetation changes will affect habitat suitability, and (3) whether these changes could be compensated by adaptive habitat management. Species presence was modelled as a function of climate, landscape and vegetation variables under current climate; moreover, vegetation-climate relationships were assessed. The models were extrapolated to the climatic conditions of 2050, assuming the moderate IPCC-scenario A1B, and changes in species’ occurrence probability were quantified. Finally, we assessed the maximum increase in occurrence probability that could be achieved by modifying one or multiple vegetation variables under altered climate conditions. Climate variables contributed significantly to explaining species occurrence, and expected climatic changes, as well as climate-induced vegetation trends, decreased the occurrence probability of all four species, particularly at the low-altitudinal margins of their distribution. These effects could be partly compensated by modifying single vegetation factors, but full compensation would only be achieved if several factors were changed in concert. The results illustrate the possibilities and limitations of adaptive species conservation management under climate change.