Abstract: <p>Residual Cancer Burden by breast cancer subtype</p>

Abstract: <p>Tumour infiltrating lymphocytes and Residual Cancer Burden</p>

Abstract: <div>AbstractPurpose:<p>Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant chemotherapy would improve tumor response in patients with breast cancer.</p>Patients and Methods:<p>Neo-train was a randomized controlled trial allocating patients with breast cancer to the usual care control (CON) group or the exercise (EX) group that received supervised high-intensity interval training and progressive resistance training 3 times weekly during 18 to 24 weeks of neoadjuvant chemotherapy. The two groups were compared on tumor size, assessed using magnetic resonance imaging as primary outcome, and secondary clinical/pathologic, biological, physical, and patient-reported outcomes.</p>Results:<p>From 2021 to 2023, 102 participants were randomly assigned to the EX (<i>n</i> = 50) or CON (<i>n</i> = 52) group. We found no between-group differences in median tumor size change from baseline to presurgery (EX vs. CON −3.0 mm [95% confidence interval (CI), −8.0 to 14.0]), the proportion with radiologic complete response [EX 65% vs. CON 56%; odds ratio 1.16 (95% CI, 0.39–3.91)], or pathologic complete response [EX 59% vs. CON 56%; odds ratio 1.03 (95% CI, 0.43–2.46)]. The exercise program was associated with higher relative dose intensity, fewer dose delays, shorter hospital stays, and increased cardiorespiratory fitness, muscle strength, and level of physical activity. We found no differences in tumor-infiltrating lymphocytes, body composition, health-related quality of life, anxiety, depression, psychological distress, or participation in rehabilitation between groups.</p>Conclusions:<p>Although the exercise program did not affect tumor size, the positive effects on chemotherapy completion and shorter hospitalizations suggest improved treatment tolerance.</p></div>

Abstract: <p>Tumour size and radiologic complete response by magnetic resonance imaging</p>

Abstract: <p>Analyses of tumour infiltrating lymphocytes</p>

Abstract: <p>Health-related quality of life, anxiety, depression and psychological distress</p>

Abstract: <p>CONSORT checklist</p>

Abstract: <p>Radiologic complete response vs pathologic complete response</p>

Abstract: Abstract Purpose Cancer prevalence is steadily rising in Europe. Many survivors experience symptoms and late effects that require management by supportive care. The inequities related to socioeconomic position (SEP) that have been described for primary anti-cancer treatment are likely to extend to the supportive care domain. This scoping review provides an overview of the existing literature assessing this relationship, and the methods used to do so. Methods A comprehensive search was executed in May 2024 in multiple databases. Studies published after 2000, including real-world data on access to, uptake of, or adherence to supportive care in relation to SEP were included. Results A total of 29 articles were included for review. Studies reported on a variety of supportive care types and were conducted primarily in Northern and Western Europe. Most studies with statistically significant findings ( n = 14) reported an association between high SEP and increased access to or uptake of supportive care ( n = 12). Conclusions Research on the association of SEP with access and uptake of supportive care is increasing but still limited. Methodology varies and is mostly exploratory. The majority of the included studies indicate that socioeconomic differences in engagement with supportive cancer care in Europe persist. More research is needed to explain the causal pathways through which SEP affects engagement with supportive care, and how its accessibility can be improved in different European countries. Implications for Cancer Survivors Efforts should be made across healthcare systems to improve accessibility to supportive cancer care for patients with a low SEP.

Abstract: <p>Cardiorespiratory fitness, muscle strength and body composition</p>

Abstract: <p>Level of physical activity and participation in municipality-based rehabilitation</p>

Abstract: <p>Methods on tumour infiltrating lymphocytes</p>

Abstract: <p>Representativeness of study participants</p>