Zuben E. Sauna
Center for Biologics Evaluation and Research
116 Papers
371 Citations
Zuben E. Sauna is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Biology & Immunogenicity. The author has an hindex of 40, co-authored 94 publications. Previous affiliations of Zuben E. Sauna include Brigham Young University & National Institutes of Health.
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Papers
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
Chava Kimchi-Sarfaty,Jung Mi Oh,In-Wha Kim,Zuben E. Sauna,Anna Maria Calcagno,Suresh V. Ambudkar,Michael M. Gottesman +6 more
TL;DR: It is hypothesized that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites.
P-glycoprotein: from genomics to mechanism
TL;DR: A model for how ATP energizes transfer of substrates from these binding sites on P-gp to the outside of the cell is proposed, which accounts for the apparent stoichiometry of two ATPs hydrolysed per molecule of drug transported.
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Understanding the contribution of synonymous mutations to human disease.
TL;DR: Current understanding of the extent to which synonymous mutations influence disease, the various molecular mechanisms that underlie these effects and the implications for future research and biomedical applications are reviewed.
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Recent advances in (therapeutic protein) drug development
H.A. Daniel Lagassé,Aikaterini Alexaki,Vijaya L. Simhadri,Nobuko H. Katagiri,Wojciech Jankowski,Zuben E. Sauna,Chava Kimchi-Sarfaty +6 more
TL;DR: This review highlights the emerging trends and approaches in protein drug development by using examples of therapeutic proteins approved by the U.S. Food and Drug Administration over the previous five years (2011–2016, namely January 1, 2011, through August 31, 2016).
Exposing synonymous mutations
TL;DR: The diverse methods to understand the effects of synonymous mutations are reviewed and it is clear that synonymous variants are important in a variety of contexts, but there is no clear consensus on the approaches to identify and validate these changes.
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