Zongxing He
5 Papers
Zongxing He is an academic researcher. The author has contributed to research in topics: Gene & Chemistry. The author has an hindex of 2, co-authored 3 publications.
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Papers
Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.
Yan Cao,Zongxing He,Qimingxing Chen,Xia He,Lili Su,Wenxia Yu,Mingming Zhang,Huiying Yang,Xingxu Huang,Jianfeng Li +9 more
TL;DR: An efficient lung-specific mRNA delivery platform named five-element nanoparticles (FNPs) is developed in which helper-polymer poly(β-amino esters) (PBAEs) and DOTAP are used in combination.
38
Design and application of the transformer base editor in mammalian cells and mice.
Wenyan Han,Bao-Qing Gao,Junjie Zhu,Zongxing He,Jianfeng Li,Liu Yang,Jia Chen +6 more
TL;DR: A new base editing system—the transformer base editor—to induce efficient editing with no observable genome-wide or transcriptome-wide off-target mutations, both in mammalian cells and in mice is described.
2
A Low Noise Microelectrode Array for Specific Cell Activity Modulation from Cell to Tissue
Bohan Zhang,Huiran Yang,Xiner Wang,Ziyi Zhu,Zongxing He,Wanqi Jiang,Chen Tao,Dujuan Zou,Meng Li,Zhitao Zhou,Liuyang Sun,Tiger H. Tao,Xiaoling Wei +12 more
- 15 Jan 2023
TL;DR: In this article , a microelectrode array (MEA) was used to enable simultaneous electrical stimulation and electrophysiological recordings with signal to noise ratios up to 30 in cellular models.
Poly(beta-amino ester)-Based Nanoparticles Enable Nonviral Delivery of Base Editors for Targeted Tumor Gene Editing.
Qimingxing Chen,Lili Su,Xia He,Jinwei Li,Yan Cao,Qingxia Wu,Jianchao Qin,Zongxing He,Xingxu Huang,Huiying Yang,Jianfeng Li +10 more
TL;DR: A series of poly(beta-amino esters) (PBAEs) with varying backbones, side chains, and end caps were synthesized to deliver plasmids of BEs and sgRNA to demonstrate that PBAEs can efficiently deliver BEs for tumor gene editing both in vitro and in vivo.
Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury
Zongxing He,Haiqiang Ma,Jianfeng Li,Huiying Yang,Rong Xie +4 more
TL;DR: Researchers developed MP-LNP-C3, a novel lipid nanoparticle formulation combining methylprednisolone and C3 transferase mRNA, to treat spinal cord injury, demonstrating enhanced efficacy, reduced inflammation, and improved motor function recovery in mouse models.