Zonghui Xiao
6 Papers
Zonghui Xiao is an academic researcher. The author has contributed to research in topics: Viral replication & Autophagy. The author has an hindex of 3, co-authored 3 publications.
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Papers
Coxsackievirus B3 Engineered To Contain MicroRNA Targets for Muscle-Specific MicroRNAs Displays Attenuated Cardiotropic Virulence in Mice
Feng He,Hailan Yao,Jianmin Wang,Zonghui Xiao,Le Xin,Zhuo Liu,Xiaolin Ma,Juan Sun,Qi Jin,Zhewei Liu +9 more
TL;DR: It is demonstrated both in vitro and in vivo that incorporating target sequences for miRNA-133 and -206 into the 5′ untranslated region of the CVB3 genome amelioratedCVB3 virulence in skeletal muscle and myocardial cells that specifically expressed the cognate cellular microRNAs.
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Coxsackievirus B3 induces autophagy in HeLa cells via the AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways.
TL;DR: The results showed that the RasGAP protein could be further cleaved, leading to the activation of the Ras/Raf/MEK (mitogen/extracellular signal-regulated kinase)/ERK pathway and that CVB3 infection could result in an increase in the concentration of calcium in the cytoplasm, resulting in mitochondrial damage, a decrease in the Concentration of ATP andactivation of the AMPK (AMP-activated protein kinase /MEK/ERK
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Engineered coxsackievirus B3 containing multiple organ-specific miRNA targets showed attenuated viral tropism and protective immunity.
TL;DR: In this article , an engineered CVB3 harboring three different tissue-specific miRNA targets (CVB3-miR3*T) was constructed to decrease the virulence of the virus in muscles, pancreas, and brain.
4
The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits Coxsackievirus 3 replication in acute viral myocarditis.
Feng He,Zhuo Liu,Miao Feng,Zonghui Xiao,Xiaoyu Yi,Jianxin Wu,Zhewei Liu,Gaoyu Wang,Le Li,Hailan Yao +9 more
TL;DR: This study identifies the lncRNA MEG3/miRNA-21/P38MAPK axis as a key regulator of Coxsackievirus 3 replication in acute viral myocarditis, with MEG3 acting as a competitive endogenous RNA of miRNA-21 and CREB5 serving as an upstream modulator.
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Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins
TL;DR: Using pharmacological inducers and inhibitors of autophagy as well as inhibitors of apoptosis, it is found that while CVB3 replication relied on the autophagosomes, its release from the cell depended on apoptosis.