Zohar Barbash
5 Papers
13 Citations
Zohar Barbash is an academic researcher. The author has contributed to research in topics: Lung cancer & Lineage (genetic). The author has an hindex of 2, co-authored 5 publications.
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Papers
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma
Nan Jin,Bhumsuk Keam,Janice Cho,Michelle J. Lee,Hye Ryun Kim,Hayarpi Torosyan,Natalia Jura,Patrick Kwok Shing Ng,Gordon B. Mills,Hua Li,Yan Zeng,Zohar Barbash,Gabi Tarcic,Hyunseok Kang,Julie E. Bauman,Mi-Ok Kim,Nathan K. VanLandingham,Danielle L. Swaney,Danielle L. Swaney,Nevan J. Krogan,Nevan J. Krogan,Daniel Johnson,Jennifer R. Grandis +22 more
TL;DR: In this article, the authors reported a patient with head and neck squamous cell carcinoma (HNSCC) with a noncanonical PIK3CA mutation (Q75E) who exhibited a durable (12 months) response to alpelisib in a phase II clinical trial.
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A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks.
TL;DR: A multi-scale deep convolutional neural network (DCNN) architecture combined with an in-vitro functional assay to investigate the functional role of VUS and their response to MTA’s and shows that responses of various mutations to FDA approved MTAs are accurately predicted by the platform in a dose dependent manner.
Revisited analysis of a SHIVA01 trial cohort using functional mutational analyses successfully predicted treatment outcome.
Maud Kamal,Gabi Tarcic,Sylvain Dureau,Oded Edelheit,Zohar Barbash,Charlotte Lecerf,Claire Morel,B. Miron,Céline Callens,Nicolas Servant,Ivan Bièche,Michael Vidne,Christophe Le Tourneau,Christophe Le Tourneau +13 more
TL;DR: The role of the functional interpretation of molecular profiles to predict MTA response was highlighted, and survival predictions according to FACT were correlated with the actual PFS of SHIVA01 patients.
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