Zoe C. Yeoh
Harvard University
5 Papers
6 Citations
Zoe C. Yeoh is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Axon. The author has an hindex of 4, co-authored 5 publications.
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Papers
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
Alfredo M. Valencia,Alfredo M. Valencia,Clayton K. Collings,Clayton K. Collings,Hai T. Dao,Roodolph St. Pierre,Roodolph St. Pierre,Yung-Chih Cheng,Yung-Chih Cheng,Junwei Huang,Junwei Huang,Zhen-Yu Sun,Hyuk-Soo Seo,Nazar Mashtalir,Nazar Mashtalir,Dawn E. Comstock,Dawn E. Comstock,Olubusayo Bolonduro,Olubusayo Bolonduro,Nicholas E. Vangos,Zoe C. Yeoh,Mary K. Dornon,Mary K. Dornon,Crystal Hermawan,Crystal Hermawan,Lee Barrett,Lee Barrett,Sirano Dhe-Paganon,Clifford J. Woolf,Clifford J. Woolf,Tom W. Muir,Cigall Kadoch,Cigall Kadoch +32 more
TL;DR: The studies unmask an evolutionarily conserved structural role for the SMARCB1 CTD that is perturbed in human disease, which results in dominant gene regulatory and morphologic changes during iPSC-neuronal differentiation.
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Yusuke Fukuda,Maria F. Pazyra-Murphy,Elizabeth S. Silagi,Ozge E. Tasdemir-Yilmaz,Yihang Li,Lillian Rose,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Hyuk-Soo Seo,Guillaume Adelmant,Gregory H. Bird,Loren D. Walensky,Jarrod A. Marto,Sirano Dhe-Paganon,Rosalind A. Segal +15 more
TL;DR: It is demonstrated that the RNA-binding protein SFPQ is preferentially transported by KIF5A rather than other motors of the kinesin-1 family, which provides a mechanistic understanding of specificity for neurologic diseases linked to the Kif5A gene.
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Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration
Yusuke Fukuda,Maria F. Pazyra-Murphy,Ozge E. Tasdemir-Yilmaz,Li Y,Lynda M. Rose,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Hyuk-Soo Seo,Guillaume Adelmant,Bird Gh,Loren D. Walensky,Jarrod A. Marto,Sirano Dhe-Paganon,Rosalind A. Segal +14 more
TL;DR: It is demonstrated that a complex containing RNA and the RNA-binding protein SFPQ interacts directly with a tetrameric kinesin containing the adaptor KLC1 and the motor KIF5A and that replacing axonally translated proteins provides a therapeutic approach to axonal degenerative disorders.
Identification of a potent and selective covalent Pin1 inhibitor.
Benika J. Pinch,Zainab M. Doctor,Behnam Nabet,Christopher M. Browne,Christopher M. Browne,Hyuk-Soo Seo,Mikaela L. Mohardt,Shingo Kozono,Xiaolan Lian,Theresa D. Manz,Theresa D. Manz,Yujin Chun,Shin Kibe,Daniel Zaidman,Dina Daitchman,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Li Tan,Scott B. Ficarro,Nir London,Jarrod A. Marto,Jarrod A. Marto,Stephen Buratowski,Sirano Dhe-Paganon,Xiao Zhen Zhou,Kun Ping Lu,Nathanael S. Gray +27 more
TL;DR: A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis / trans isomerase NIMA-interacting 1 (Pin1) is used to show thatPin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation and that Pin1 inhibition impairs cell viability over time in PDAC cell lines.
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy
Liwei Jiang,Yi-Jun Wang,Jing Zhao,Mayuko Uehara,Qingming Hou,Qingming Hou,Vivek Kasinath,Takaharu Ichimura,Naima Banouni,Li Dai,Xiaofei Li,Dale L. Greiner,Leonard D. Shultz,Xiaolong Zhang,Zhen-Yu Jim Sun,Ian Curtin,Nicholas E. Vangos,Zoe C. Yeoh,Ezekiel A. Geffken,Hyuk-Soo Seo,Ze-Xian Liu,Gregory J. Heffron,Khalid Shah,Khalid Shah,Sirano Dhe-Paganon,Reza Abdi,Reza Abdi +26 more
TL;DR: A paradigm to control cancer growth that is based on both direct tumor killing and the triggering of protective immunity is described, which permits a combination of tumor ablation, interference within the TME, and immunotherapy in one potential modality.