Ziwei Li

TL;DR: The role of exosomes in the three phases of tumor immunoediting is introduced in detail, and relevant literature on exosome in the tumor immune microenvironment is summarized by using a novel framework for extracting relevant documents as discussed by the authors .

TL;DR: PHM is a promising and safe vehicle for siRNA delivery and may find utility in cancer therapy and achieve an improved anticancer effect compared to naked siRNA.

Abstract: Nanotechnologies seek to overcome inherent deficiencies of conventional diagnosis and treatment, which attracted sustained attention and a limited number of nanomedicines approved by the FDA. However, the critical gaps in clinical translation remain, and nanomedicines that were initially heralded as magic bullets have yet to reach their realistic potential. The major obstacles of fabrication technologies may be overlooked in the nanoparticles’ journey. Suboptimal manufacturing strategies partly hampered the inefficient transformation. In this review, we discuss the nanoparticle manufacturing strategies of “Top-Down” and “Bottom-Up” on precise nanoscale fabrication, including artificial intelligence introduced to guided nanomedicine fabrication for accelerating the transformation. Re-engineering existing nanomedicine fabrication, individual manufacturing, and modular technology might highlight the dilemmas of nanomedicines to meet their initial expectations.

TL;DR: The results showed that FA-LP-GCK can significantly reduce joint swelling and can significantly inhibit the expression of pro-inflammatory cytokines and improve synovial hyperplasia of joints and pathological changes in the spleen, suggesting it may be a potential therapeutic approach for RA.