Zipeng Cao
New York University
4 Papers
Zipeng Cao is an academic researcher from New York University. The author has contributed to research in topics: Cyclin D1 & Inhibitor of apoptosis. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Zipeng Cao include Fourth Military Medical University.
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Papers
Cyclin D1 Downregulation Contributes to Anticancer Effect of Isorhapontigenin on Human Bladder Cancer Cells
TL;DR: The studies show that isorhapontigenin is an active compound that mediates Gnetum Cleistostachyum's induction of cell-cycle G0–G1 arrest and inhibition of cancer cell anchorage-independent growth through downregulating SP1/cyclin D1 axis in bladder cancer cells.
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X-linked Inhibitor of Apoptosis Protein (XIAP) Regulation of Cyclin D1 Protein Expression and Cancer Cell Anchorage-independent Growth via Its E3 Ligase-mediated Protein Phosphatase 2A/c-Jun Axis
Zipeng Cao,Zipeng Cao,Ruowen Zhang,Jingxia Li,Haishan Huang,Haishan Huang,Dongyun Zhang,Jingjie Zhang,Jimin Gao,Jingyuan Chen,Chuanshu Huang +10 more
TL;DR: A novel function of E3 ligase activity of XIAP is uncovered in the up-regulation of cyclin D1 expression, providing significant insight into the understanding of the biomedical significance of overexpressed XIAP in cancer development and further offering a new molecular basis for utilizing XIAP E 3 ligase as a cancer therapeutic target.
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X-linked inhibitor of apoptosis protein (XIAP) lacking RING domain localizes to the nuclear and promotes cancer cell anchorage-independent growth by targeting the E2F1/Cyclin E axis
TL;DR: It is shown that expressing XIAP with RING (Really Interesting New Gene) domain deletion (XIAPΔRING) in cancer cells promoted cancer cell anchorage-independent growth and G1/S phase transition companied with increasing cyclin e transcription activity and protein expression.
SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells.
Zipeng Cao,Zipeng Cao,Xueyong Li,Jingxia Li,Beipei Kang,Jingyuan Chen,Wenjing Luo,Chuanshu Huang +7 more
TL;DR: The results strongly demonstrate that SUMOylated RhoGDIα suppressed C‐Jun/AP‐1‐dependent transactivation specifically via targeting MEK1/2‐Erk, subsequently leading to the down‐regulation of cyclin D1 expression and anti‐cancer activity.
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