Zigor Aira
University of the Basque Country
17 Papers
151 Citations
Zigor Aira is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Agonist & Postsynaptic potential. The author has an hindex of 10, co-authored 17 publications.
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Papers
Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury.
Zigor Aira,Itsaso Buesa,Monika Salgueiro,Juan Bilbao,Luciano Aguilera,Manfred Zimmermann,Jon Jatsu Azkue +6 more
TL;DR: Deep subtype-specific changes in the functional modulatory activities of spinal serotonin receptors following peripheral nerve injury are revealed, and spinal hyperexcitation promoted by receptors 5-HT2A and 5- HT2B is suggested as a novel pathogenic pathway contributing to neuropathic pain.
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Embodied pain in fibromyalgia: Disturbed somatorepresentations and increased plasticity of the body schema
TL;DR: A disturbed embodiment is suggested in FMS, characterized by instability of the body schema, negatively biased cognitions regarding one’s own body, and increased vigilance to internal bodily cues.
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Time-Dependent Cross Talk between Spinal Serotonin 5-HT2A Receptor and mGluR1 Subserves Spinal Hyperexcitability and Neuropathic Pain after Nerve Injury
Zigor Aira,Itsaso Buesa,Mónica Gallego,Gontzal García del Caño,Nahia Mendiable,Janire Mingo,Diego Rada,Juan Bilbao,Manfred Zimmermann,Jon Jatsu Azkue +9 more
TL;DR: A role for 5-HT2AR in hyperexcitation and pain after nerve injury is emphasized and mGluR1 upregulation is supported as a novel feedforward activation mechanism contributing to 5- HT2AR-mediated facilitation.
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Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors.
Zigor Aira,Itsaso Buesa,Gontzal García del Caño,Monika Salgueiro,Nahia Mendiable,Janire Mingo,Luciano Aguilera,Juan Bilbao,Jon Jatsu Azkue +8 more
TL;DR: Results indicate that plasticity of spinal serotonergic neurotransmission can selectively reduce spinal MOR mechanisms via 5‐HT2A and 5‐ HT2B receptors, including upregulation of the latter and increased expression in dorsal horn neurons containing MOR.
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Spinal D1-like dopamine receptors modulate NMDA receptor-induced hyperexcitability and NR1 subunit phosphorylation at serine 889
TL;DR: The present results support that D1LRs regulate most basic determinants of NMDAR function in dorsal horn neurons, suggesting a potential mechanism whereby dopaminergic input to the dorsal horn can modulate central sensitization and pathologic pain.
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