Zige Jiang
9 Papers
Zige Jiang is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 4 publications.
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Papers
3D Gelatin Microsphere Scaffolds Promote Functional Recovery after Spinal Cord Hemisection in Rats
Hongfei Ke,Hongru Yang,Yijing Zhao,Tingting Li,Danqing Xin,Chengcheng Gai,Zige Jiang,Zhen Wang +7 more
TL;DR: In this article , solid 3D gelatin microsphere (GM) scaffolds with multiple voids were constructed and tested for spinal cord injury, and they demonstrated suitable biocompatibility, biodegradation, porosity, low preparation costs, and relative ease of production.
31
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury.
Yijing Zhao,Tong Li,Zige Jiang,Chengcheng Gai,Shuwen Yu,Danqing Xin,Tingting Li,Dexiang Liu,Zhen Wang +8 more
TL;DR: H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoring β-synthase expression, thereby playing a role in reducing neuro inflammation in hypoxia and ischemia.
10
Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2
Zige Jiang,Dexiang Liu,Tingting Li,Chengcheng Gai,Danqing Xin,Yijing Zhao,Yan Song,Yahong Cheng,Tong Li,Zhen Wang +9 more
TL;DR: It is shown that H2S reduces oxidative stress in Huntington’s disease by activating Nrf2, suggesting that H2S is a novel neuroprotective drug candidate for treating patients with Huntington’s disease.
4
Mitochondria-targeted cerium vanadate nanozyme suppressed hypoxia-ischemia injury in neonatal mice via intranasal administration.
Zige Jiang,Wenhan Wang,Yijing Zhao,Tingting Li,Danqing Xin,Chengcheng Gai,Dexiang Liu,Zhen Wang +7 more
TL;DR: CeVO4 nanozyme administration led to short- and long-term functional recovery following HI insult without any potential toxicities in peripheral organs of mice even after prolonged delivery for 4 weeks and it was found that Nrf2 inhibition with ML385 abolished the protective effects of CeVO4 nanozyme on HI injury.
3
MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke
Danqing Xin,Tingting Li,Yijing Zhao,Xiaofan Guo,Chengcheng Gai,Zige Jiang,Shuwen Yu,Jiao Cheng,Yan Song,Yahong Cheng,Qian Luo,Bing Gu,Dexiang Liu,Zhen Wang +13 more
TL;DR: Ischemic stroke triggers neurons to produce EVs containing miR-100-5p, which exacerbate neuroinflammation and neuronal damage by activating microglia and inducing apoptosis through TLR7-NF-κB pathway, highlighting a potential therapeutic target for stroke treatment.