The invention provides a micro-droplet driving device based on dielectric wetting, which includes an upper layer chip and a lower layer chip. The upper layer chip includes an upper base board, and a reference electrode layer and a hydrophobic layer arranged successively on the surface of the upper base board. The lower layer chip includes a lower base board, and a control electrode array and a functional layer arranged successively on the surface of the lower base board. The functional is made from CYTOP. The hydrophobic layer on the upper layer chip and the functional layer on the lower layer chip are arranged opposite to each other. A support object is disposed between the upper layer chip and the lower layer chip to form a space for accommodating a micro-droplet in a mechanical connection manner. The reference electrode layer and the control electrode array are both electrically connected to a control circuit through wires. The micro-droplet driving device is simple in structure. In the lower layer chip, a CYTOP layer is used for replacing a two-layer structure composed of a hydrophobic layer and a dielectric layer in the prior art. The micro-droplet driving device is low in required driving voltage and achieves flexible operation to micro-droplets. The invention also provides a production method of the micro-droplet driving device.

Micro-droplet driving device based on dielectric wetting and preparation method thereof

The invention discloses an electrolysis device based on an electrowetting-on-dielectric layer principle, and a manufacturing method thereof. The electrolysis device includes: a lower electrode plate formed by sequentially arranging a first substrate, an electrode layer, a dielectric layer and a first hydrophobic layer from bottom to top; and an upper electrode plate formed by sequentially arranging a second substrate, a grounding electrode and a second hydrophobic layer from top to bottom; liquid drops D to be electrolyzed are placed between the first hydrophobic layer and the second hydrophobic layer; the electrode layer includes a plurality of electrolysis electrodes and a plurality of driving electrodes, and adjacent electrodes are electrically isolated; and the electrolysis electrodes are embedded into the driving electrodes. Liquid drops containing a specific concentration of electrolysis products with different polarities can be obtained by controlling the electrolysis process and the liquid drop splitting process. The electrolysis device has the characteristics of novel design, simple control, high automation degree and high output precision, and greatly widens the application range of digital micro-fluidics, onsite rapid detection and other technologies.

Electrolysis device based on electrowetting-on-dielectric layer principle, and manufacturing method thereof

The invention provides a micro-fluidic chip and a detecting and driving method thereof, an on-chip laboratory system. The micro-fluidic chip comprises an electrode layer, a dielectric layer and a lyophobic layer which are successively formed on a substrate. The electrode layer comprises multiple electrode units which are regularly arranged. The electrode units are used for realizing liquid drop detection and liquid drop drive through applying a detection signal and a drive signal. Compared with a current liquid drop drive and detection separating structure, the micro-fluidic chip has the advantages of high integration level, simple structure, simple and convenient control and the like, is capable of not only realizing miniaturization, but also realizing high automation, improving application efficiency of the digital micro-fluidic chip, widening an application range of the micro-fluidic chip, and effectively simplifying an on-chip laboratory system structure, has very important significance to further optimize the on-chip laboratory system, and has huge development potential and extensive application prospect.

Micro-fluidic chip and detecting and driving method thereof, on-chip laboratory system

The invention provides an electrochemical detection chip and a detection method thereof and relates to the field of electrochemical detection based on a digital microfluidic technology. The electrochemical detection chip applies drive signals to drive electrodes to control droplet separation and moves to corresponding detection positions for detection, so that the instillation time is saved; meanwhile, multiple small droplets can be separated from an instillation reagent each time and move to the corresponding detection positions, the volume of required droplets is in the microliter scale, thereagent consumption is lower, and accordingly, the detection cost can be reduced. The electrochemical detection chip comprises a first substrate and a second substrate which are arranged oppositely,wherein multiple independent drive electrodes are arranged on one side of the first substrate; first detection electrodes and second detection electrodes which are spaced are arranged in positions, directly facing at least part of drive electrodes, of one side, facing the first substrate, of the second substrate.

Electrochemical detection chip and detection method thereof

A micro-fluidic chip with movable channel side wall surface at designated position comprises a cover plate and a substrate which are matched and combined into a main body structure of the chip; the cover plate has a microchannel structure; a conventional microchannel is not provided with a groove structure A and a groove structure B; the movable wall surface is a solid PDMS thin layer of which the deformation capability is determined by the positions and intervals of the groove structure A, the groove structure B and the main channel; the intervals between the groove structure A, the grove structure B and the main channel are smaller enough than the width and height of the main channel; the solid PDMS thin layer is deformed under the flowing action of fluid in the main channel, and meanwhile, the groove structure A and the grove structure B provide space for the deformation of the main channel; the deformable structure is made at the designated position at the side wall surface of the microchannel to affect flowing of the fluid, and an action of regulating generation of liquid drops is further achieved.

Micro-fluidic chip with movable channel side wall surface at designated position

The invention belongs to the technical field of digital micro-fluidic control, and in particular discloses a digital micro-fluidic chip capable of generating accurate liquid drops. On the basis of a conventional bipolar plate digital micro-fluidic chip, a group of micro driving electrodes is additionally arranged between a conventional square driving electrode and a liquid storage pool electrode at a liquid drop generation part of the conventional chip so as to form a dumbbell-shaped structure, wherein the group of micro driving electrodes is used for generating and splitting liquid drops; parallel side walls are arranged between bipolar plates of the chip and are positioned over the micro driving electrodes; the parallel side walls and upper and lower polar plates of the chip form a micro pipeline through which the liquid drops flow; the inner diameter of the micro pipeline is equal to or smaller than the width of an elongated electrode, so that the liquid drops in the pipeline can be effectively driven by the elongated electrode. By virtue of the chip, the generation accuracy of the liquid drops can be greatly improved; great significance can be achieved for lab and commercial application of the digital micro-fluidic chip.

Digital micro-fluidic chip capable of generating accurate liquid drops

The invention belongs to the technical field of integrated micro analysis chips and in particular relates to an integrated electrochemical sensing chip. The chip comprises two parts, namely a digital micro-fluidic driving module arranged on a lower pole plate of the chip for generating, transporting, mixing and separating micro-scale droplets, so that liquid samples can be automatically controlled; and an integrated electrochemical sensing module arranged on an upper pole plate of the chip, so that micro real-time and rapid electrochemical detection can be performed. The chip has the advantages of novel design, high integration level, convenience in operation, high degree of automation and the like and can be applied to the fields of automatic micro analysis and lab-on-a-chip.

Integrated electrochemical sensing chip

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Digital micro-fluidic chip capable of generating accurate liquid drops

Integrated electrochemical sensing chip