Background—Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis. The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed. Methods and Results—Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively. In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02). Activation of the transcription factor nuclear factor-κB (NF-κB) determined by electrophoretic mobility shift assay and κB-dependent transcriptional activity was enhanced in the presence of activated platelets. In addition, ADP-activated platelets induced MCP-1 and ICAM-1 p...

Activated Platelets Induce Monocyte Chemotactic Protein-1 Secretion and Surface Expression of Intercellular Adhesion Molecule-1 on Endothelial Cells

The present analysis investigated the role of GPVI for platelet activation and platelet-mediated endothelial activation in patients with type 2 diabetes. The major findings of the present study are: a) patients with type 2 diabetes have an enhanced platelet surface expression of FcgRIIA that correlates with GPVI expression compared with non-diabetic patients; b) stimulation of GPVI results in substantial secretion of CD40L in normal control platelets, GPVI-dependent CD40L release is enhanced in type 2 diabetes as compared with non-diabetes; c) soluble GPVI inhibits GPVI-induced secretion of platelet CD40L; d) co-incubation of cultured endothelial cells with GPVI/ligation-stimulated platelets induces substantial endothelial activation.

Characteristics of Platelet Surface Expression of Glycoprotein VI in Type 2 Diabetes

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Characteristics of Platelet Surface Expression of Glycoprotein VI in Type 2 Diabetes