Zhonghui Zhu
Capital Medical University
31 Papers
29 Citations
Zhonghui Zhu is an academic researcher from Capital Medical University. The author has contributed to research in topics: Fibrosis & Pulmonary fibrosis. The author has an hindex of 12, co-authored 21 publications.
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Papers
MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model.
Jingping Sun,Qiuyue Li,Ximeng Lian,Zhonghui Zhu,Xiaowei Chen,Wanying Pei,Siling Li,Ali Abbas,Yan Wang,Lin Tian +9 more
TL;DR: It is demonstrated that miR-29b acted as a novel negative regulator of silicosis fibrosis-inhibited lung fibrosis, probably by promoting MET and by suppressing EMT in the lung.
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Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model
Chunjie Xu,Jing Zhao,Qiuyue Li,Lin Hou,Yan Wang,Siling Li,Fuyang Jiang,Zhonghui Zhu,Lin Tian +8 more
TL;DR: Two studies support a potential role for hucMSC-Exos in ameliorating pulmonary fibrosis and provide new evidence for improving clinical treatment induced by silica.
BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway.
TL;DR: The restoration of BMP signaling with BMP-7 is associated with inhibiting silica-induced fibrosis through the mechanisms of activated B MP-7/Smad and suppressed TGF-β/ Smad pathways.
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Exosomal let-7i-5p from three-dimensional cultured human umbilical cord mesenchymal stem cells inhibits fibroblast activation in silicosis through targeting TGFBR1.
TL;DR: In this paper , a three-dimensional (3D) method was applied to culture hucMSCs and MRC-5 cells (human embryonic lung fibroblasts), and exosomes were isolated from serum-free media, identified by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), and Western blotting analysis.
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FOXO3 promoted mitophagy via nuclear retention induced by manganese chloride in SH-SY5Y cells.
Dongmei Song,Junxiang Ma,Li Chen,Caixia Guo,Yuanyuan Zhang,Tian Chen,Shixuan Zhang,Zhonghui Zhu,Lin Tian,Piye Niu +9 more
TL;DR: The results indicated that Mn could induce mitophagy by enhancing FOXO3 nuclear retention, which might promoteMitophagy induced by MnCl2.
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