78 Papers
436 Citations
Zhiyi Wei is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Biology & Ankyrin. The author has an hindex of 32, co-authored 73 publications. Previous affiliations of Zhiyi Wei include University of Ottawa & Chinese Academy of Sciences.
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Papers
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Zhihong Cheng,Travis L. Biechele,Zhiyi Wei,Zhiyi Wei,Seamus Morrone,Randall T. Moon,Liguo Wang,Wenqing Xu +7 more
TL;DR: Crystal structures of a human LRP6-E3E4–DKK1 complex and the first and second halves of human L RP6's four propeller–epidermal growth factor (EGF) pairs are presented to provide key insights for understanding LRP5/6 structure and the interaction of LRP 5/6 with DKK, as well as for drug discovery.
197
Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
TL;DR: The structure of the Cascade complex provides novel molecular details of protein–protein and protein–RNA alignments and interactions required for generation of a complex mediating RNA-guided immune surveillance and explains why the seed sequence has a critical role in target DNA recognition.
183
Structural basis of kindlin-mediated integrin recognition and activation
Huadong Li,Yi Deng,Kang Sun,Haibin Yang,Haibin Yang,Jie Liu,Meiling Wang,Zhang Zhang,Jirong Lin,Chuanyue Wu,Chuanyue Wu,Zhiyi Wei,Zhiyi Wei,Cong Yu +13 more
TL;DR: The structural, biochemical, and cellular results provide mechanistic explanations that account for the effects of kindlins on integrin activation as well as for how kindlin mutations found in patients with Kindler syndrome and leukocyte-adhesion deficiency may impact integrin-mediated processes.
156
Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Youjun Li,Hao Zhou,Fengzhi Li,Siew Wee Chan,Zhijie Lin,Zhiyi Wei,Zhou Yang,Fusheng Guo,Chun Jye Lim,Wancai Xing,Yuequan Shen,Wanjin Hong,Jiafu Long,Mingjie Zhang +13 more
TL;DR: It is shown by high-resolution crystal structures that the Lats1/2-binding site on the Merlin FERM domain is physically blocked by Merlin's auto-inhibitory tail, and angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling, and allow construction of a complete Hippo signalling pathway.
Myosin VI Undergoes Cargo-Mediated Dimerization
TL;DR: The high-resolution NMR structure of the cargo-free myosin VI cargo-binding domain (CBD) is reported and it is shown that it is a stable monomer in solution and may represent a general paradigm for the regulation of processivity for myOSin VI as well as other myosins, including myosIn VII and myos in X.
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