Zhimin Chen
University of Michigan
23 Papers
7 Citations
Zhimin Chen is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Zhimin Chen include Chinese Academy of Sciences & Children's National Medical Center.
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Papers
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.
Xuelian Xiong,Xuelian Xiong,Henry Kuang,Sahar Ansari,Tongyu Liu,Jianke Gong,Jianke Gong,Shuai Wang,Xu-Yun Zhao,Yewei Ji,Chuan Li,Liang Guo,Linkang Zhou,Zhimin Chen,Paola León-Mimila,Meng Ting Chung,Katsuo Kurabayashi,Judy S. Opp,Francisco Campos-Pérez,Hugo Villamil-Ramírez,Samuel Canizales-Quinteros,Robert H. Lyons,Carey N. Lumeng,Beiyan Zhou,Ling Qi,Adriana Huertas-Vazquez,Aldons J. Lusis,X.Z. Shawn Xu,Siming Li,Yonghao Yu,Jun Z. Li,Jiandie D. Lin +31 more
TL;DR: The emergence of NASH-associated macrophages (NAMs) is uncovered, which is marked by high expression of triggering receptors expressed on myeloid cells 2 (Trem2), as a feature of mouse and human NASH that is linked to disease severity and highly responsive to pharmacological and dietary interventions.
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The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
Guoxiao Wang,Xu Yun Zhao,Zhuo Xian Meng,Matthias Kern,Arne Dietrich,Zhimin Chen,Zoharit Cozacov,Dequan Zhou,Adewole L. Okunade,Xiong Su,Siming Li,Matthias Blüher,Jiandie D. Lin +12 more
TL;DR: Nrg4 is established as a brown fat–enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
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Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression
Liang Guo,Peng Zhang,Zhimin Chen,Houjun Xia,Siming Li,Yanqiao Zhang,Sune Kobberup,Weiping Zou,Jiandie D. Lin +8 more
TL;DR: Hepatic Nrg4 signaling serves as an endocrine checkpoint for steatosis-to-NASH progression by activating a cytoprotective pathway to counter stress-induced liver injury.
Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders
Zhimin Chen,Guoxiao Wang,Sara L. Ma,Dae Young Jung,Hyekyung Ha,Tariq R. Altamimi,Xu Yun Zhao,Liang Guo,Peng Zhang,Chun-Rui Hu,Ji-Xin Cheng,Gary D. Lopaschuk,Jason K. Kim,Jiandie D. Lin +13 more
TL;DR: Nrg4 exerts pleiotropic beneficial effects on energy balance and glucose and lipid metabolism to ameliorate obesity-associated metabolic disorders and may improve both type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in patients.
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Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
Shensi Shen,Pengtao Zhang,Martin A. Lovchik,Ying Li,Liuya Tang,Zhimin Chen,Rong Zeng,Dawei Ma,Junying Yuan,Qiang Yu +9 more
TL;DR: This study shows that an oxazoline analogue of apratoxin A (oz-apraA), a cyclodepsipeptide isolated from a marine cyanobacterium, promotes the degradation of Hsp90 clients through chaperone-mediated autophagy (CMA), and provides the first examples for the ability of CMA to mediate degradation of membrane receptors and cross talks of C MA and proteasomal degradation mechanisms.
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