Zhihong Lu
University of Alabama at Birmingham
14 Papers
339 Citations
Zhihong Lu is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Dihydropyrimidine dehydrogenase & Fluorouracil. The author has an hindex of 12, co-authored 14 publications.
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Papers
•Journal Article
Dihydropyrimidine Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells and Liver: Population Characteristics, Newly Identified Deficient Patients, and Clinical Implication in 5-Fluorouracil Chemotherapy
TL;DR: A sensitive, accurate, and precise DPD assay and a storage method to stabilize DPD activity are developed, permitting large scale DPD screening in cancer patients and a normal distribution (Gaussian distribution) of human D PD activity from peripheral blood mononuclear cells (PBM-DPD) in a population study.
406
Purification and characterization of dihydropyrimidine dehydrogenase from human liver
TL;DR: A novel procedure for purification of dihydropyrimidine dehydrogenase from human liver is reported, with new data on its properties compared to other species, which will provide a basis for further biochemical and molecular studies of this enzyme.
155
Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects
Ruiwen Zhang,Jieming Yan,Harout Shahinian,Girish Amin,Zhihong Lu,Tiepu Liu,Michael S. Saag,Zhiwei Jiang,Jamal Temsamani,R. Russell Martin,Paul J. Schechter,Sudhir Agrawal,Robert B. Diasio +12 more
TL;DR: Human pharmacokinetics of an antisense oligodeoxynucleotide phosphorothioate developed as an anti—human immunodeficiency virus (HIV) agent was carried out and radioactivity in plasma and urine was associated with lower molecular weight metabolites.
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Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1
Ruiwen Zhang,Robert B. Diasio,Zhihong Lu,Tiepu Liu,Zhiwei Jiang,Wayne M. Galbraith,Sudhir Agrawal +6 more
TL;DR: The pharmacokinetic parameters for GEM 91 in each tissue and biological fluids were calculated using computer-based two-compartmental i.v. bolus or absorption models to understand the pharmacology and toxicology of antisense oligodeoxynucleotide phosphorothioates, in general.
130
•Journal Article
Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy.
TL;DR: DPD activity was determined in 50 pairs of tumor and uninvolved liver specimens in Chinese cancer patients with hepatocellular carcinoma and hepatomas were found to have relatively high DPD activity, providing an explanation for the relative 5-fluorouracil resistance of hepatoma.
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