Zhenping Zhong
University of Texas Health Science Center at Houston
4 Papers
20 Citations
Zhenping Zhong is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Gene expression & P-bodies. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Zhenping Zhong include University of Texas at Austin.
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Papers
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
Akio Yamashita,Tsung Cheng Chang,Yukiko M. Yamashita,Wenmiao Zhu,Zhenping Zhong,Chyi-Ying A. Chen,Ann-Bin Shyu +6 more
TL;DR: The results show that deadenylation is the key first step that triggers decay of both wild-type stable and nonsense codon–containing unstable β-globin mRNAs in mouse NIH3T3 fibroblasts.
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Versatile applications of transcriptional pulsing to study mRNA turnover in mammalian cells
Chyi-Ying A. Chen,Yukiko M. Yamashita,Yukiko M. Yamashita,Tsung Cheng Chang,Tsung Cheng Chang,Akio Yamashita,Akio Yamashita,Wenmiao Zhu,Zhenping Zhong,Ann-Bin Shyu +9 more
TL;DR: This study applies the Tet-off transcriptional pulsing strategy to investigate ARE-mediated mRNA decay in human erythroleukemic K562 cells arrested at various phases of the cell cycle by pharmacological inhibitors, and establishes a tTA-harboring stable line using human bronchial epithelial BEAS-2B cells.
Coordinated Changes in mRNA Turnover, Translation, and RNA Processing Bodies in Bronchial Epithelial Cells following Inflammatory Stimulation†
Yuxin Zhai,Zhenping Zhong,Chyi-Ying A. Chen,Zhenfang Xia,Ling Song,Michael R. Blackburn,Ann-Bin Shyu +6 more
TL;DR: This study reveals an orchestrated change among posttranscriptional mechanisms, which help sustain high levels of inflammatory mediator production in bronchial epithelium during the pathogenesis of inflammatory airway diseases.
Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.
Nader Ezzeddine,Tsung Cheng Chang,Tsung Cheng Chang,Wenmiao Zhu,Akio Yamashita,Akio Yamashita,Chyi-Ying A. Chen,Zhenping Zhong,Yukiko M. Yamashita,Yukiko M. Yamashita,Dinghai Zheng,Ann-Bin Shyu +11 more
TL;DR: Results from glutathione S-transferase pull-down and coimmunoprecipitation experiments indicate that TOB can simultaneously interact with the poly(A) nuclease complex CCR4-CAF1 and the cytoplasmicpoly(A)-binding protein, PABPC1.