Zhenping Wang
University of California, San Diego
44 Papers
29 Citations
Zhenping Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 11, co-authored 33 publications. Previous affiliations of Zhenping Wang include Chongqing University & Third Military Medical University.
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Papers
Mast Cells Are Key Mediators of Cathelicidin-Initiated Skin Inflammation in Rosacea
TL;DR: It is demonstrated that MCs play a central role in the development of inflammation subsequent to Cath LL-37 activation and that down regulation of activated MCs may be a therapy for rosacea treatment.
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Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes
Zhenping Wang,N. Mascarenhas,Lars Eckmann,Yukiko Miyamoto,Xiaojun Sun,Toshiaki Kawakami,Anna Di Nardo +6 more
TL;DR: A novel mechanism is revealed by which the skin microbiota signals the recruitment and maturation of MCs within the dermis through SCF production by LTA‐stimulated keratinocytes, which triggers the differentiation of dermal MCs.
116
Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides
Zhenping Wang,Yuping Lai,Jamie J. Bernard,Daniel T. MacLeod,Anna L. Cogen,Bernard Moss,Anna Di Nardo +6 more
TL;DR: It is demonstrated that MC presence protects mice from VV skin infection, MC degranulation is required for protecting mice fromVV, and antimicrobial peptide release from MC granules is necessary to inactivate VV infectivity.
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
TL;DR: In conclusion, encapsulation of celastrol by niosomes increased the water-solubility and permeation of Celastrol into the skin, significantly improving its anti-psoriasis activity in mice.
96
Commensal Bacteria Lipoteichoic Acid Increases Skin Mast Cell Antimicrobial Activity against Vaccinia Viruses
TL;DR: The research shows that signaling through TLR2 increases the production and expression of cathelicidin in mast cells, thereby enhancing their capacity to fight vaccinia virus.
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