Zhenping Li
University of Chicago
18 Papers
28 Citations
Zhenping Li is an academic researcher from University of Chicago. The author has contributed to research in topics: Biology & Ubiquitin ligase. The author has an hindex of 11, co-authored 15 publications.
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Papers
Cutting Edge: CTLA-4–B7 Interaction Suppresses Th17 Cell Differentiation
Haiyan Ying,Lifen Yang,Lifen Yang,Guilin Qiao,Zhenping Li,Li Zhang,Fei Yin,Dong Xie,Jian Zhang +8 more
TL;DR: It is reported in this paper that blocking the CTLA-4–B7 interaction potentiates Th17 cell differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.
T-Cell Receptor-Induced NF-κB Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b
Guilin Qiao,Zhenping Li,Luciana Molinero,Maria-Luisa Alegre,Haiyan Ying,Zuoming Sun,Josef M. Penninger,Jian Zhang +7 more
TL;DR: The data provide the first evidence to demonstrate that the down-regulation of TCR-induced NF-κB activation by Cbl-b is mediated coordinately by both Akt-dependent and PKC-θ-dependent signaling pathways in primary T cells.
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E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation
Guilin Qiao,Haiyan Ying,Yixia Zhao,Yanran Liang,Hui Guo,Hui Guo,Huifeng Shen,Zhenping Li,Julian Solway,Enxiang Tao,Y. Jeffrey Chiang,Stanley Lipkowitz,Josef M. Penninger,Wallace Y. Langdon,Jian Zhang +14 more
TL;DR: It is reported that the loss of Cbl-b facilitates T helper 2 (Th2) and Th9 cell differentiation in vitro and introduces Stat6 deficiency into Cblb−/− mice abrogates hyper-Th2 responses but only partially attenuates Th9 responses.
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T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells
Guilin Qiao,Yixia Zhao,Yixia Zhao,Yixia Zhao,Zhenping Li,Peter Q. Tang,Wallace Y. Langdon,Tianlan Yang,Jian Zhang +8 more
TL;DR: It is reported that the optimal induction of Foxp3 by naive CD4+CD25− T cells requires suboptimal TCR triggering and that in vivo iTreg development is also controlled by Cbl-b via tuning the TCR strength.
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Syk mediates BCR- and CD40-signaling integration during B cell activation.
TL;DR: It is found that spleen tyrosine kinase (Syk) is involved in CD40 signaling, and is synergistically activated in B cells in response to BCR/CD40 costimulation.
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