Zhenmin Le
5 Papers
Zhenmin Le is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 4 publications.
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Papers
A highly selective fluorescent probe for visualizing dry eye disease-associated viscosity variations
Lili Lian,Ruirui Zhang,Zhenmin Le,Lixiong Dai,Yueping Ren,Xiao-Qi Yu,Ji-Ting Hou,Jianliang Shen +7 more
TL;DR: Wang et al. as discussed by the authors constructed a fluorescent probe V5 with an asymmetric donor-acceptor-donor (D-A-D) feature after rational structural modulation for viscosity detection during DED progression.
23
SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation
Lili Lian,Zhenmin Le,Zhenzhen Wang,Yingting Chen,Xiaodong Jiao,Hang Qi,J. Fielding Hejtmancik,Xiaoyin Ma,Qinxiang Zheng,Yueping Ren +9 more
TL;DR: In this article , small interfering RNAs (siRNAs) targeting NLRP3, TXNIP, and SIRT1, as well as a lentiviral vector (LV) were used to determine whether SIRT 1 regulates high glucose (HG)induced inflammation and cataract formation through modulating NLRP 3/NLRP 3 inflammasome activation in human lens epithelial cells (HLECs) and rat lenses.
21
Fluorescence Imaging of Diabetic Cataract-Associated Lipid Droplets in Living Cells and Patient-Derived Tissues.
Shuai Guo,Lili Lian,Zhenmin Le,Yueping Ren,Ye-Xin Liao,Jianliang Shen,Ji-Ting Hou +6 more
TL;DR: More LDs were found in lens epithelial tissues from DC patients than in cataract tissues for the first time, and it is anticipated that this work can attract more attention to the important roles of LDs during DC progression.
11
Mo-Based Mo2Ti2C3 MXene as Photothermal Nanoagents to Eradicating Methicillin-Resistant Staphylococcus Aureus with Photothermal Therapy
TL;DR: In this article , Mo2Ti2C3 (MTC) is used for photo-to-heat conversion of a 2D transition metal carbide (MXene) to prevent the growth of methicillin-resistant Staphylococcus aureus (MRSA).
10
Upregulation of SLC12A3 and SLC12A9 Mediated by the HCP5/miR-140-5p Axis Confers Aggressiveness and Unfavorable Prognosis in Uveal Melanoma.
Congcong Yan,Xiaojuan Hu,Xiaoyan Liu,JingTing Zhao,Zhenmin Le,Jiayao Feng,Meng Zhou,Xiaoyin Ma,Qing-huan Zheng,Jie Sun +9 more
TL;DR: An integrative multiomics analysis of the SLC 12 family in multicenter UVM datasets found that high expression of SLC12A3 and SLC11A9 was associated with unfavorable prognosis, and the HCP5-miR-140-5p axis was identified as a potential noncoding RNA pathway upstream of S LC12A1, which may represent a novel predictor for clinical prognosis and responsiveness to checkpoint blockade immunotherapy.